Results 11 to 20 of about 494,112 (301)
Molecular Biology Reports, 2021 Codon usage bias is the preferential or non-random use of synonymous codons, a ubiquitous phenomenon observed in bacteria, plants and animals. Different species have consistent and characteristic codon biases. Codon bias varies not only with species, family or group within kingdom, but also between the genes within an organism.
Sujatha Thankeswaran Parvathy +2 more
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The Codon Statistics Database: A Database of Codon Usage Bias
Molecular Biology and Evolution, 2022 Abstract We present the Codon Statistics Database, an online database that contains codon usage statistics for all the species with reference or representative genomes in RefSeq (over 15,000). The user can search for any species and access two sets of tables.
Felix Feyertag +2 more
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Mechanism of Virus Attenuation by Codon Pair Deoptimization
Cell Reports, 2020 Summary: Codon pair deoptimization is an efficient virus attenuation strategy, but the mechanism that leads to attenuation is unknown. The strategy involves synthetic recoding of viral genomes that alters the positions of synonymous codons, thereby ...
Nicole Groenke +2 more
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Synonymous but Not Silent: The Codon Usage Code for Gene Expression and Protein Folding
Annual Review of Biochemistry, 2021 Codon usage bias, the preference for certain synonymous codons, is found in all genomes. Although synonymous mutations were previously thought to be silent, a large body of evidence has demonstrated that codon usage can play major roles in determining ...
Yi Liu, Fangzhou Zhao
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Codon optimality, bias and usage in translation and mRNA decay
Nature Reviews Molecular Cell Biology, 2017 The advent of ribosome profiling and other tools to probe mRNA translation has revealed that codon bias — the uneven use of synonymous codons in the transcriptome — serves as a secondary genetic code: a code that guides the efficiency of protein ...
Jeff Coller, Coller Jeff
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Journal of Molecular Biology, 2019 Usage of sequential codon-pairs is non-random and unique to each species. Codon-pair bias is related to but clearly distinct from individual codon usage bias.
Aikaterini Alexaki +2 more
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Optimization of Col H Gene Encoding Clostridium histolyticum Collagenase to Express in Escherichia coli [PDF]
Journal of Health Sciences and Surveillance System, 2022 Background: A given amino acid sequence can be encoded by a huge number of different nucleic acid sequences. These sequences, however, have proved not to be equally useful.
Seyed Mohammad Amin Mahdian +3 more
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Proceedings of the National Academy of Sciences of the United States of America, 2016 Zhipeng Zhou, Yunkun Dang, Mian Zhou
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Overview of tRNA Modifications in Chloroplasts
Microorganisms, 2022 The chloroplast is a promising platform for biotechnological innovation due to its compact translation machinery. Nucleotide modifications within a minimal set of tRNAs modulate codon–anticodon interactions that are crucial for translation efficiency ...
Maxime Fages-Lartaud +1 more
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Molecular Therapy, 2021 Mis-regulated epigenetic modifications in RNAs are associated with human cancers. The transfer RNAs (tRNAs) are the most heavily modified RNA species in cells, however, little is known about the functions of tRNA modifications in cancers.
Jieyi Ma +12 more
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