Results 111 to 120 of about 95,149 (294)
RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu +21 more
wiley +1 more source
Clustering of classical swine fever virus isolates by codon pair bias
BMC Research Notes, 2011 Background The genetic code consists of non-random usage of synonymous codons for the same amino acids, termed codon bias or codon usage. Codon juxtaposition is also non-random, referred to as codon context bias or codon pair bias.
Leifer Immanuel +4 more
doaj +1 more source
Why genes evolve faster on secondary chromosomes in bacteria [PDF]
, 2010 In bacterial genomes composed of more than one chromosome, one replicon is typically larger, harbors more essential genes than the others, and is considered primary.
Cooper, Vaughn S. +3 more
core +1 more source
An Engineered Living Material With Pro‐Angiogenic Activity Inducible by Near‐Infrared Light
Advanced Functional Materials, EarlyView.NIR‐responsive engineered living materials (ELMs) for controlled angiogenesis: Near‐infrared (800 nm) light activates engineered probiotic bacteria within alginate‐based living materials to secrete a blood vessel‐regenerating protein. The released protein promotes pro‐angiogenic effects in endothelial networks and chick chorioallantoic membranes.
Anwesha Chatterjee +4 more
wiley +1 more source
Advanced Functional Materials, EarlyView.The nanostructure, size, and function of mRNA‐loaded lipid nanoparticles are evaluated before drying, within polymer microneedles, and after rehydration. The results reveal the polymer and LNP loadings required to recover nanostructure and preserve the delivery performance in dry‐state formulations.
Brendan P. Dyett +19 more
wiley +1 more source
Genome-wide analysis of the synonymous codon usage patterns in apple
Journal of Integrative Agriculture, 2016 Apple (Malus×domestica) has been proposed as an important woody plant and the major cultivated fruit trees in temperate regions. Apple whole genome sequencing has been completed, which provided an excellent opportunity for genome-wide analysis of the ...
Ning LI +4 more
doaj +1 more source
Four basic symmetry types in the universal 7-cluster structure of 143 complete bacterial genomic sequences [PDF]
, 2004 Coding information is the main source of heterogeneity (non-randomness) in the sequences of bacterial genomes. This information can be naturally modeled by analysing cluster structures in the ``in-phase'' triplet distributions of relatively short genomic
Gorban, A.N. +2 more
core +1 more source
Advanced Healthcare Materials, EarlyView.Potato virus X is a filamentous RNA plant virus that can be engineered into a molecular tool for cancer therapy. We produced genetically‐encoded virus‐derived nanoparticles decorated with nanobodies targeting cancer cell receptors, epidermal growth factor receptor (EGFR) and human epidermal growth factor 2 (HER2).
Enrique Lozano‐Sanchez +4 more
wiley +1 more source
eLife, 2018 Codon usage biases are found in all genomes and influence protein expression levels. The codon usage effect on protein expression was thought to be mainly due to its impact on translation.
Zhipeng Zhou +4 more
doaj +1 more source
Trypanosomatidae codon usage and GC distribution
Memórias do Instituto Oswaldo Cruz, 1992 A study of Trypanosomatidae GC distribution and codon usage is presented. The codon usage patterns in coincidence with the phylogenetical data are similar in Crithidia and Leishmania, whereas they are more divergent in Trypanosoma brucei and T. cruzi. The analysis of the GC mutational pressure in these organisms reveals that T.
Alonso, Guilhermina +2 more
openaire +4 more sources