Results 1 to 10 of about 96,165 (278)
Adaptive evolution is substantially impeded by Hill–Robertson interference in Drosophila [PDF]
, 2015 Hill–Robertson interference (HRi) is expected to reduce the efficiency of natural selection when two or more linked selected sites do not segregate freely, but no attempt has been done so far to quantify the overall impact of HRi on the rate of adaptive ...
Adam Eyre-Walker +18 more
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Codon usage bias reveals genomic adaptations to environmental conditions in an acidophilic consortium. [PDF]
PLoS ONE, 2018 The analysis of codon usage bias has been widely used to characterize different communities of microorganisms. In this context, the aim of this work was to study the codon usage bias in a natural consortium of five acidophilic bacteria used for biomining.
Andrew Hart +3 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2023 IntroductionNeurodegeneration and cancer present in comorbidities with inverse effects due to the expression of genes and pathways acting in opposition.
Rekha Khandia +5 more
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Solving the riddle of codon usage preferences: a test for translational selection [PDF]
, 1998 Translational selection is responsible for the unequal usage of synonymous codons in protein coding genes in a wide variety of organisms. It is one of the most subtle and pervasive forces of molecular evolution, yet, establishing the underlying causes ...
A Kaminskii +17 more
core +3 more sources
Codon Pair Bias and Viral Vaccine Design [PDF]
Advances in Genetic Engineering & Biotechnology, 2012 Live attenuated vaccines (LAVs) have prevented morbidity and mortality against a number of important viral diseases (such as smallpox and polio) via long-lived humoral and cell-mediated immunity. Unlike inactivated, subunit or recombinant protein vaccines which require multiple inoculations this cost-effective approach requires only one or two doses ...
Luke, Garry Alec +3 more
openaire +3 more sources
Enterovirus A Shows Unique Patterns of Codon Usage Bias in Conventional Versus Unconventional Clade
Frontiers in Cellular and Infection Microbiology, 2022 Enterovirus A (EV-A) species cause hand, foot and mouth disease (HFMD), threatening the health of young children. Understanding the mutual codon usage pattern of the virus and its host(s) has fundamental and applied values.
Liyan Zeng +7 more
doaj +1 more source
Optimized expression of the Starmerella bombicola lactone esterase in Pichia pastoris through temperature adaptation, codon-optimization and co-expression with HAC1 [PDF]
, 2018 The Starmerella bombicola lactone esterase (SBLE) is a novel enzyme that, in vivo, catalyzes the intramolecular esterification (lactonization) of acidic sophorolipids in an aqueous environment.
Ciesielska, Katarzyna +8 more
core +2 more sources
Modelling the Efficiency of Codon–tRNA Interactions Based on Codon Usage Bias [PDF]
DNA Research, 2014 The tRNA adaptation index (tAI) is a widely used measure of the efficiency by which a coding sequence is recognized by the intra-cellular tRNA pool. This index includes among others weights that represent wobble interactions between codons and tRNA molecules.
Sabi, Renana, Tuller, Tamir
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Evolutionary pressures on the yeast transcriptome [PDF]
, 2015 Codon usage bias (CUB) is the well known phenomenon that the frequency of synonymous codons is unequal. This is presumably the result of adaptive pressures favouring some codons over others.
Chu, Dominique, Salykin, Anton
core +1 more source
Selection intensity for codon bias.
Genetics, 1994 Abstract The patterns of nonrandom usage of synonymous codons (codon bias) in enteric bacteria were analyzed. Poisson random field (PRF) theory was used to derive the expected distribution of frequencies of nucleotides differing from the ancestral state at aligned sites in a set of DNA sequences.
D L, Hartl, E N, Moriyama, S A, Sawyer
openaire +2 more sources