Results 111 to 120 of about 434,859 (315)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Error estimates for the numerical identification of a variable coefficient [PDF]

, 1983
Error estimates are derived for the approximate identification of an unknown transmissivity coefficient in a partial differential equation describing a model problem in groundwater flow.
Richard S. Falk
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Distributional Limits and GINI Coefficient. [PDF]

This paper examines the Gini (1912) coefficient of concentration using the framework set out by Dalton (1920) for evaluating a measure of inequality. Particular attention is paid to limited distributions and the associated concept of 'perfect inequality'.
Van de Ven, J.
core  

Coefficient estimates for mountain goat resource selection. [PDF]

, 2019
Coefficient estimates from the top match-case control multiple logistic regression model of mountain goat resource selection during July and August afternoons (12:00–18:00).
Mark Biel (3370574), Wesley Sarmento (8115323), Joel Berger (377097)   +2 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Some Classes of Harmonic Mapping with a Symmetric Conjecture Point Defined by Subordination

Mathematics, 2019
In the paper, we introduce some subclasses of harmonic mapping, the analytic part of which is related to general starlike (or convex) functions with a symmetric conjecture point defined by subordination.
Lina Ma, Shuhai Li, Xiaomeng Niu
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Applications of Caputo-Type Fractional Derivatives for Subclasses of Bi-Univalent Functions with Bounded Boundary Rotation

Fractal and Fractional
In this article, for the first time by using Caputo-type fractional derivatives, we introduce three new subclasses of bi-univalent functions associated with bounded boundary rotation in an open unit disk to obtain non-sharp estimates of the first two ...
Kholood M. Alsager, Gangadharan Murugusundaramoorthy, Adriana Catas, Sheza M. El-Deeb   +3 more
doaj   +1 more source

Nonparametric Estimate of Regression Coefficients

The Annals of Mathematical Statistics, 1971
1. Summary and introduction. The present investigation is a follow up of [7] to a class of multiple regression problems, and is devoted to the construction of an estimate of regression parameter vector based on suitable rank statistics. Asymptotic linearity of these rank statistics in the multiple regression set up is established and the asymptotic ...
openaire   +2 more sources