Results 51 to 60 of about 23,905 (268)

Large-Strain Nonlinear Consolidation of Sand-Drained Foundations Considering Vacuum Preloading and the Variation in Radial Permeability Coefficient

open access: yesBuildings, 2023
The vacuum preloading method effectively strengthens soft soil foundations with vertical drainage, which produces a smear effect when laying sand drains.
Zan Xu   +4 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Consolidation Solution for Sand-drained Ground with Impeded Boundaries Under Vacuum Preloading

open access: yes工程科学与技术, 2018
Since the cushion generally exists on the top and a substratum below the bottom of sand-drained ground,impeded boundaries were used to describe its effect on consolidation process of sand-drained ground.Assuming that ground deformation satisfies the ...
Yayuan HU
doaj  

Research on Test Method of Foundation Bed Coefficient in Nanjing Soft Soil Area

open access: yesGeofluids, 2021
Relying on the geotechnical engineering survey project of Nanjing Lukou Airport, this research adopts the method of combining in situ and indoor testing to analyze the coefficient of soil foundation under different conditions (flow plastic, plastic, and ...
Min Zhang, Tao Qiu
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

A Hansbo's consolidation solution of sand-drained ground with impeded boundaries under vacuum and surcharge preloading

open access: yes工程科学学报, 2018
The top and bottom boundaries of sand-drained ground were visualized as impeded boundaries to investigate the effects of the pervious behaviors of the cushion above the top and the substratum below the bottom during the consolidation process of sand ...
HU Ya-yuan
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

ESTIMATION OF RELATIONSHIP BETWEEN COEFFICIENT OF CONSOLIDATION AND LIQUID LIMIT OF MIDDLE AND SOUTH IRAQI SOILS

open access: yesJournal of Engineering, 2011
In this paper, a relationship between the liquid limit and the coefficient of consolidation of Iraqi soils are studied. The samples of soil used in study are undisturbed silty clay.
Asma Y. Al- Tae′e   +1 more
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

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