Results 61 to 70 of about 167,489,176 (300)
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
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FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
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Consolidation Solution for Sand-drained Ground with Impeded Boundaries Under Vacuum Preloading
工程科学与技术, 2018 Since the cushion generally exists on the top and a substratum below the bottom of sand-drained ground,impeded boundaries were used to describe its effect on consolidation process of sand-drained ground.Assuming that ground deformation satisfies the ...
Yayuan HU
doaj
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
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Shanghai Jiaotong Daxue xuebaoConsidering the self-gravity stress of the soil around the tunnel, a two-dimensional nonlinear consolidation control equation for saturated soil was established, and solved using the alternating implicit difference method. The correctness of the solution
HU Anfeng, CHEN Yuchao, XIAO Zhirong, XIE Senlin, GONG Zhaoqi
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工程科学学报, 2018 The top and bottom boundaries of sand-drained ground were visualized as impeded boundaries to investigate the effects of the pervious behaviors of the cushion above the top and the substratum below the bottom during the consolidation process of sand ...
HU Ya-yuan
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
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Research on Test Method of Foundation Bed Coefficient in Nanjing Soft Soil Area
Geofluids, 2021 Relying on the geotechnical engineering survey project of Nanjing Lukou Airport, this research adopts the method of combining in situ and indoor testing to analyze the coefficient of soil foundation under different conditions (flow plastic, plastic, and ...
Min Zhang, Tao Qiu
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