Results 61 to 70 of about 23,905 (268)
Shanghai Jiaotong Daxue xuebaoConsidering the self-gravity stress of the soil around the tunnel, a two-dimensional nonlinear consolidation control equation for saturated soil was established, and solved using the alternating implicit difference method. The correctness of the solution
HU Anfeng, CHEN Yuchao, XIAO Zhirong, XIE Senlin, GONG Zhaoqi
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
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Stress-dependent consolidation characteristics of marine clay in the Northern Arabian Gulf
Ain Shams Engineering Journal, 2018 The main objective of this paper is to study the variation of the coefficient of consolidation (Cv) with stress level for the marine clay in the Northern Arabian Gulf.
Tamer Elkateb
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
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Dinamika Rekayasa, 2008 Soft clay is kind of problem in building and highway foundation design. This type of soils, have low coefficient consolidation (Cv) parameter. This condition will cause that soils have very long duration in consolidation process.
Arwan Apriyono +2 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
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An Investigation of Time-Dependent Deformation Characteristics of Soft Dredger Fill
Advances in Civil Engineering, 2020 The creep characteristics of soft clays have been studied for decades. However, the lateral deformation of soils is not allowed during the commonly used one-dimensional consolidation tests, which cannot describe the real deformation features of soils in ...
Wanying Wang +3 more
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
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