Results 61 to 70 of about 2,695,475 (278)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Effect of Refrigerant Charge on the Performance of Air-source Heat Pump Water Heater

Zhileng xuebao, 2018
In this paper, the effects of a refrigerant charge on the system performance of a heat pump water heater and the regulating characteristics of the electronic expansion valve were studied experimentally.
Yuan Zhaoyang, Tao Leren, Yu Zhongyang, Gu Zhipan   +3 more
doaj  

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

The effect of flow coefficient on the design of miniature centrifugal impeller [PDF]

, 2011
This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece.
3rd Micro and Nano Flows Conference (MNF2011), Chan, WK, Liu, G   +2 more
core  

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Determination of Coefficient of Performance of Stirling Refrigeration sm

International Journal of Innovative Technology and Exploring Engineering, 2019
Refrigeration is a process of reducing the temperature of the desired space under atmospheric temperature. The present system focuses on the design and fabrication of a Stirling refrigeration system with a β-type configuration. The refrigerants carbon dioxide and helium are used and the efficient among them is determined.
Sampath Suranjan, Jomu Sabu John, Ashish Joseph Mathew, Joshua Jose, Gokul Joshy, Aswin Ramesh, Sachidananda H K*   +6 more
openaire   +1 more source

The Effect of Workloads and Compensation on Work Motivation in Sasmita Jaya Foundation [PDF]

, 2019
The complexity of motivational problems has always been an obstacle to employee performance. Therefore, it is important to do research on the causal factors. To answer this problem, quantitative approaches and regression analysis are used. The population
Harras, H. (Hadyati)
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Performance evaluation and sensitivity analysis of a low- capacity single-effect LiBr-H2O absorption cooling system using energy and exergy modeling

Journal of Applied Science and Engineering
In industrialized cooling systems, LiBr − H₂O is widely utilized as the predominant working fluid, particularly in absorption systems for maintaining the thermal comfort of building occupants.
Syed Maaz Hasan, Muhammad Saad Ul Haq, Abdul Waheed Badar, M Zahid Iqbal Qureshi, Majid Ali, M. Salman Siddiqi   +5 more
doaj   +1 more source

The assessment of applicability of single-stage piston long-stroke low-speed compressors in low-temperature refrigeration machines [PDF]

Омский научный вестник: Серия "Авиационно-ракетное и энергетическое машиностроение"
The work processes and integral characteristics of low-temperature ammonia single-stage piston longstroke low-speed compressors are considered. A method for calculating the actual working process of a stage of such a compressor is presented, taking into
V. L. Yusha, S. S. Busarov, A. V. Nedovenchany   +2 more
doaj   +1 more source