Results 71 to 80 of about 2,695,475 (278)

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Studi Variasi Laju Pengeluaran Kalor Kondensor High Stage Sistem Refrigerasi Cascade Menggunakan Refrigeran MC22 dan R404A dengan Heat Exchanger Tipe Concentric Tube

Jurnal Teknik ITS, 2013
Masih adanya kekurangan pada alat penukar panas tipe compact yang digunakan pada sistem refrigerasi cascade sebelumnya, pada studi eksperimental ini dibuat kembali suatu sistem refrigerasi cascade dengan alat penukar panas tipe concentric.
Faberto Subrida, Ary Bachtiar Khrisna Putra   +1 more
doaj  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Studi Variasi Laju Pelepasan Kalor Kondensor High Stage Sistem Refrigerasi Cascade R22 Dan R404a Dengan Heat Exchanger Tipe Concentric Tube

Jurnal Teknik ITS, 2014
Sistem refrigerasi cascade merupakan kombinasi dua sistem refrigerasi tunggal yang digunakan untuk mendapatkan temperatur sangat rendah dimana aplikasinya adalah sebagai cold storage.
Royyan Firdaus, Ary Bachtiar Khrisna Putra   +1 more
doaj  

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Effect of a Heating System Using a Ground Source Geothermal Heat Pump on Production Performance, Energy-Saving and Housing Environment of Pigs

Animals, 2020
This study examined the effects of a heating system using a ground source geothermal heat pump (GHP). A GHP was installed in a pig house, and a comparative analysis was performed between the GHP and the control (conventional heating system) in terms of ...
Hong Seok Mun, Muhammad Ammar Dilawar, Myeong Gil Jeong, Dhanushka Rathnayake, Jun Sung Won, Kwang Woo Park, Sang Ro Lee, Sang Bum Ryu, Chul Ju Yang   +8 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Guided entry performance of low ballistic coefficient vehicles at Mars

2012 IEEE Aerospace Conference, 2012
Current Mars entry, descent, and landing technology is near its performance limit and may be unable to land payloads on the surface that exceed 1 metric ton. One option for increasing landed payload mass capability is decreasing the entry vehicle’s hypersonic ballistic coefficient.
Meginnis, Ian, Putnam, Zachary, Clark, Ian, Braun, Robert, Barton, Gregg   +4 more
openaire   +3 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Break-even coefficient of performance: Scenario-based analysis of industrial heat electrification feasibility in Europe

Energy Conversion and Management
This study used the Break-even Coefficient of Performance (COP) and the subsequent Break-even temperature outside heat integration studies as performance indicators for evaluating the viability of investments in industrial heat pumps taking a top-down approach.
Roger Padullés, Ioannis Kountouris, Baris Burak Kanbur, Jonas Kjær Jensen, Brian Elmegaard   +4 more
openaire   +1 more source