Results 71 to 80 of about 4,393 (216)

David Garbers' Contributions to Chemotaxis Signaling in Sperm

Molecular Reproduction and Development, Volume 91, Issue 10, October 2024.
ABSTRACT This review focuses on the contribution of the late David Garbers to chemotaxis of sperm, in particular from sea urchin. We will describe his discovery of chemotactic peptides and their cognate receptors, his discovery of a sperm‐specific, unique Na+/H+ exchanger that represents a chimera between a solute carrier (SLC) and an ion channel ...
U. B. Kaupp, Olivia Kendall
wiley   +1 more source

Molecular characterization and immune association of Fas‐associated death domain protein (FADD) in Tenebrio molitor

Entomological Research, Volume 54, Issue 9, September 2024.
Abstract Fas‐associated death domain protein (FADD) is an apoptotic adapter molecule that recruits caspases and facilitates the formation of death‐inducing signaling complexes in mammals. In lower animals, FADD forms a complex with immune deficiency and death‐related ced‐3/Nedd2‐like caspase to elicit antimicrobial responses.
Keunho Yun, Ho Am Jang, Bharat Bhusan Patnaik, Su Hyeon Hwang, Yong Seok Lee, Yeon Soo Han, Yong Hun Jo   +6 more
wiley   +1 more source

Lectins identify distinct populations of coelomocytes in Strongylocentrotus purpuratus. [PDF]

PLoS ONE, 2017
Coelomocytes represent the immune cells of echinoderms, but detailed knowledge about their roles during immune responses is very limited. One major challenge for studying coelomocyte biology is the lack of reagents to identify and purify distinct ...
Wen-Yun Liao, Sebastian D Fugmann
doaj   +1 more source

Non‐viral Gene Therapy for Melanoma Using Lysenin from Eisenia Foetida

Advanced Science, Volume 11, Issue 17, May 8, 2024.
A nanoparticle‐mediated gene therapy based on Lysenin, an exogenous pore‐forming protein from earthworm Eisenia foetida, holds promise for cancer treatment by directly killing the transfected cancer cells and inducing the anticancer immunity, which inspires the development of future cancer therapeutics related to pore‐forming proteins.
Min Ren, Ling Yang, Liming He, Jie Wang, Wei Zhao, Chunli Yang, Shuai Yang, Hao Cheng, Meijuan Huang, Maling Gou   +9 more
wiley   +1 more source

Age- and stress-associated C. elegans granulins impair lysosomal function and induce a compensatory HLH-30/TFEB transcriptional response. [PDF]

, 2019
The progressive failure of protein homeostasis is a hallmark of aging and a common feature in neurodegenerative disease. As the enzymes executing the final stages of autophagy, lysosomal proteases are key contributors to the maintenance of protein ...
Ashrafi, Kaveh, Butler, Victoria J, Caballero, Benjamin, Coppola, Giovanni, Corrales, Christian I, Cortopassi, Wilian A, Cuervo, Ana Maria, Gao, Fuying, Jacobson, Matthew P, Kao, Aimee W, Vohra, Mihir   +10 more
core   +1 more source

Neuropeptide expression and action in the reproductive system of the starfish Asterias rubens

Journal of Comparative Neurology, Volume 532, Issue 1, January 2024.
The expression and action of neuropeptides in the reproductive system of the starfish Asterias rubens were investigated, as illustrated here for ArPPLN2h. This neuropeptide is expressed in the coelomic epithelial layer of the gonads [CE(Gd); arrowheads] in both female (a) and male (b) animals, and it causes relaxation of ovary (c) and testis (d ...
Victor M. Piñon Gonzalez, Yuling Feng, Michaela Egertová, Maurice R. Elphick   +3 more
wiley   +1 more source

A new Caenorhabditis elegans model to study copper toxicity in Wilson disease

Traffic, Volume 25, Issue 1, January 2024.
C. elegans CUA‐1 is an ortholog of human ATP7B, mutations in which cause Wilson disease (WD). The copper‐transporting activity of CUA‐1 counteracts copper toxicity by sequestering excess copper ions in lysosomes and promoting their efflux to the extracellular space.
Federico Catalano, Thomas J. O'Brien, Aleksandra A. Mekhova, Lucia Vittoria Sepe, Mariantonietta Elia, Rossella De Cegli, Ivan Gallotta, Pamela Santonicola, Giuseppina Zampi, Ekaterina Y. Ilyechova, Aleksei A. Romanov, Polina D. Samuseva, Josephine Salzano, Raffaella Petruzzelli, Elena V. Polishchuk, Alessia Indrieri, Byung‐Eun Kim, André E. X. Brown, Ludmila V. Puchkova, Elia Di Schiavi, Roman S. Polishchuk   +20 more
wiley   +1 more source

Fragments of -thymosin from the sea urchin Paracentrotus lividus as potential antimicrobial peptides against staphylococcal biofilms [PDF]

, 2012
The immune mediators in echinoderms can be a potential source of novel antimicrobial peptides (AMPs) applied toward controlling pathogenic staphylococcal biofilms that are intrinsically resistant to conventional antibiotics. The peptide fraction
Arizza, V., Cusimano, M., Schillaci, D., Vitale, M.   +3 more
core   +1 more source

Unraveling the Impact of Climate Change on Fish Physiology: A Focus on Temperature and Salinity Dynamics

Journal of Applied Ichthyology, Volume 2024, Issue 1, 2024.
In recent decades, climate change has significantly altered the environmental dynamics of aquatic ecosystems, profoundly impacting the intricate balance of life within them. This review paper delves into the multifaceted impacts of climate change on the physiology of aquatic life, emphasizing temperature and salinity as pivotal ecological factors ...
Deepak Agarwal, Seerappalli Aran Shanmugam, Ayyathurai Kathirvelpandian, Suresh Eswaran, Mohd Ashraf Rather, Gowrimanohari Rakkannan, Pronob Das   +6 more
wiley   +1 more source

Comparative Effects of Ingested PVC Micro Particles With and Without Adsorbed Benzo(a)pyrene vs. Spiked Sediments on the Cellular and Sub Cellular Processes of the Benthic Organism Hediste diversicolor

Frontiers in Marine Science, 2018
Plastic micro litter represents an emerging contaminant as well as a multiple stress agent in aquatic environments. Microplastics are found even in the remote areas of the world.
Alessio Gomiero, Alessio Gomiero, Pierluigi Strafella, Giulio Pellini, Vera Salvalaggio, Gianna Fabi   +5 more
doaj   +1 more source