Results 101 to 110 of about 308,164 (234)

Pangenome Analysis of the Plant Pathogen Pseudomonas syringae Reveals Unique Natural Products for Niche Adaptation

Angewandte Chemie, EarlyView.
A pangenome analysis of the plant pathogen Pseudomonas syringae reveals two novel natural product families that facilitate niche adaptation. Comprehensive genomic and chemical analyses uncover unique biosynthetic gene clusters linked to host specificity and environmental fitness.
Shuaibing Zhang, Ying Huang, Raed Nachawati, Philipp Huber, Grit Walther, Lucas Gregor, Ivan Vilotijević, Pierre Stallforth   +7 more
wiley   +2 more sources

Association Between Vascular NOTCH3 Aggregation and Disease Severity in a CADASIL Cohort – Implications for NOTCH3 Variant‐Specific Disease Prediction

Annals of Neurology, EarlyView.
Objective Vascular NOTCH3 protein ectodomain aggregation is a pathological hallmark of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a monogenic small vessel disease typically caused by cysteine‐altering variants in NOTCH3.
Minne N. Cerfontaine, Gido Gravesteijn, Remco J. Hack, Kyra L. Dijkstra, Mar Rodríguez‐Girondo, Benno Gesierich, Marie‐Noëlle W. Witjes‐Ané, Remco van Doorn, Marco Duering, Julie W. Rutten, Saskia A. J. Lesnik Oberstein   +10 more
wiley   +1 more source

An Artificial Metal‐Free Peroxidase Designed Using a Ferritin Cage for Bioinspired Catalysis

Angewandte Chemie, EarlyView.
Designing artificial enzymes remains challenging due to the need for precise active site control. Here, we present a simple strategy to create metal‐free artificial enzymes by engineering Histidine clusters inside a ferritin cage. The resulting catalyst mimics peroxidase activity, and its stable cage structure offers new insights into supramolecular ...
Jiaxin Tian, Basudev Maity, Tadaomi Furuta, Tiezheng Pan, Takafumi Ueno   +4 more
wiley   +2 more sources

Structural Basis of Sequential Enantioselective Epoxidation by a Flavin‐Dependent Monooxygenase in Lasalocid A Biosynthesis

Angewandte Chemie, EarlyView.
Lsd18 is a flavin‐dependent monooxygenase from Streptomyces lasalocidi that performs two enantioselective epoxidations during lasalocid A biosynthesis. X‐ray crystal structures of Lsd18 bound to a substrate and product analogue illuminate how this enzyme performs multiple epoxidations on the same substrate molecule and how it controls stereoselectivity.
Qian Wang, Yaming Deng, Dayan Viera, Xiaopeng Liu, Ning Liu, Yulu Hu, Xiangdong Hu, Hao Wei, Quan Zhou, Ting Lan, Wei He, Xi Chen, Chu‐Young Kim   +12 more
wiley   +2 more sources

Unlocking Lactonase Enzymes as Biocatalysts for the Deracemisation of Chiral γ‐Thiolactones

Angewandte Chemie, EarlyView.
The application of lactonase enzymes as biocatalysts still remains underexplored. This study discloses the biocatalytic activity of two lactonases in the deracemisation of chiral C3‐substituted‐γ‐thiolactones. The biocatalyst GcL catalyses the enzymatic kinetic resolution (EKR) of C3‐amide‐thiolactones, while the rationally engineered biocatalyst N9 ...
Jingyue Wu, Michele Crotti, Ivan Bassanini, Mahdi Hassankalhori, Erica Elisa Ferrandi, Ferran Sancho, Daniela Monti, Daniele Castagnolo   +7 more
wiley   +2 more sources

High‐Pressure Synthesis of Ultra‐Incompressible Beryllium Tungsten Nitride Pernitride BeW10N14(N2)

Angewandte Chemie, EarlyView.
The first ternary transition metal pernitride was synthesized in a high‐temperature high‐pressure approach starting from W2Be4N5. The structure features not only the rare structural motif of BeN6 octahedra but also dinitrogen anions. DFT calculations reveal ultra‐incompressible and metallic behavior of the new compound.
Georg Krach, Lukas Brüning, Sebastian Ambach, Elena Bykova, Nico Giordano, Björn Winkler, Maxim Bykov, Wolfgang Schnick   +7 more
wiley   +2 more sources

Early Neonatal Fosdenopterin Treatment for Molybdenum Cofactor Deficiency Type A: New Insights into Its Natural History and Potential Role for Fetal Therapy. [PDF]

J Clin Med
Etchegaray A, Haffner D, Cruz SM, Ogunleye O, Xia J, Schlegel A, Olutoye OO, Chaudhari BP.   +7 more
europepmc   +1 more source

Cooperative Photometallobiocatalysis: Nonheme Fe Enzyme‐Catalyzed Enantioconvergent Radical Decarboxylative Azidation, Thiocyanation, and Isocyanation of Redox‐Active Esters

Angewandte Chemie, EarlyView.
Through the directed evolution of an underexploited nonheme Fe extradiol dioxygenase, we developed a unified cooperative photobiocatalytic strategy to allow for three types of enantioconvergent radical transformations, including azidation, thiocyanation, and isocyanation.
Liu‐Peng Zhao, Ken Lin, Pei‐Pei Xie, Huichong Liu, Hengye Xiang, Xin Liu, Yunlong Zhao, Peng Liu, Yang Yang   +8 more
wiley   +2 more sources

Biochemical Studies of a Cyanobacterial Halogenase Support the Involvement of a Dimetal Cofactor. [PDF]

Biochemistry
Wang ML, Glasser NR, Nair MA, Krebs C, Martin Bollinger J, Balskus EP.   +5 more
europepmc   +1 more source

Taxonomy of Chemical Bondings: Opportunities and Challenges

Angewandte Chemie, EarlyView.
The recent focus on supramolecular and nanosized systems produced a major increase in the types of observed noncovalent interactions and in the diversity of terms used to designate them. A hierarchical categorization (taxonomy) of terms used to designate electrophile···nucleophile interactions is proposed here.
Andrea Pizzi, Giancarlo Terraneo, Cristina Lo Iacono, Roberta Beccaria, Arun Dhaka, Giuseppe Resnati   +5 more
wiley   +2 more sources