Results 81 to 90 of about 221,534 (298)

A role for cofactor–cofactor and cofactor–histone interactions in targeting p300, SWI/SNF and Mediator for transcription

The EMBO Journal, 2003
Transcriptional activation from chromatin by nuclear receptors (NRs) requires multiple cofactors including CBP/p300, SWI/SNF and Mediator. How NRs recruit these multiple cofactors is not clear. Here we show that activation by androgen receptor and thyroid hormone receptor is associated with the promoter targeting of SRC family members, p300, SWI/SNF ...
Zhi-Qing, Huang, Jiwen, Li, Laurent M, Sachs, Philip A, Cole, Jiemin, Wong   +4 more
openaire   +3 more sources

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Archaeal heme a synthase: evolutionary trajectory distinct from bacterial homologs

Frontiers in Microbiology
Hemes are iron-containing porphyrin compounds that play a crucial role in a wide array of biological processes. Heme a synthase (HAS) is a crucial enzyme that facilitates the biosynthesis of heme a, an essential heme variant that serves as a cofactor in ...
Val Karavaeva, Val Karavaeva, Marco Rampin, Jordi Zamarreño Beas, Lígia M. Saraiva, Filipa L. Sousa   +5 more
doaj   +1 more source

Metal and cofactor insertion

, 2007
Cells require metal ions as cofactors for the assembly of metalloproteins. Principally one has to distinguish between metal ions that are directly incorporated into their cognate sites on proteins and those metal ions that have to become part of ...
Smith, Alison G., Warren, Martin J., Mendel, Ralf, Marquet, Andrée   +3 more
core   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Nucleocapsid Structure of Negative Strand RNA Virus

Viruses, 2020
Negative strand RNA viruses (NSVs) include many important human pathogens, such as influenza virus, Ebola virus, and rabies virus. One of the unique characteristics that NSVs share is the assembly of the nucleocapsid and its role in viral RNA synthesis ...
Ming Luo, James Ross Terrell, Shelby Ashlyn Mcmanus   +2 more
doaj   +1 more source

Cofactor-Controlled Chirality of Tropoisomeric Ligand [PDF]

, 2016
A new tropos ligand with an integrated anion receptor receptor site has been prepared. Chiral carboxylate and phosphate anions that bind in the anion receptor unit proved capable of stabilizing chiral conformations of the achiral flexible bidentate ...
Bellini, Rosalba,, Paweł Dydio (1793911), Rosalba Bellini (1408486), Szabo, Z., van der Werf, A., Sander, R.A., Dydio, Pawel, van der Werf, Angela,, Moberg, C., Zoltan Szabo (2043043), Reek, Joost N. H., Moberg, Christina,, Dydio, P., Joost N. H. Reek (1319472), Christina Moberg (1408489), Reek, J.N.H., Angela van der Werf (2801668), Sander, Robin Afshin,, Théveau, L., Theveau, Laure,, Bellini, R., Robin Afshin Sander (2801674), Szabo, Zoltan,, Laure Théveau (2801671)   +23 more
core   +2 more sources

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

An NADH dependent reductase for isolated enzyme and whole cell catalysis. [PDF]

, 2006
Isolated enzymes and whole cell biocatalysts can both be applied for the synthesis of chiral hydroxy compounds. It is hypothesized that whole cells can easily be employed for such reactions using simple technology which is robust.
Shorrock, Vicky Jane, Shorrock, V.J.
core