Results 61 to 70 of about 341,197 (295)

Separable Hamiltonian equations on Riemann manifolds and related integrable hydrodynamic systems

, 2002
A systematic construction of St\"{a}ckel systems in separated coordinates and its relation to bi-Hamiltonian formalism are considered. A general form of related hydrodynamic systems, integrable by the Hamilton-Jacobi method, is derived.
Antonowicz, Antonowicz, Benenti, Benenti, Błaszak, Błaszak, Błaszak, Błaszak, Eisenhart, Falqui, Ferapontov, Ferapontov, Ibort, Jaulent, Lundmark, Ma, Maciej Błaszak, Marciniak, Marciniak, Rauch-Wojciechowski, Sklyanin, Tsarev, Wen-Xiu Ma, Zeng, Zeng, Zeng, Zeng, Zeng   +27 more
core   +1 more source

A computational framework to emulate the human perspective in flow cytometric data analysis [PDF]

, 2012
Background: In recent years, intense research efforts have focused on developing methods for automated flow cytometric data analysis. However, while designing such applications, little or no attention has been paid to the human perspective that is ...
AP Dempster, B Ellis, B Lindsay, BG Lindsay, BW Silverman, BW Silverman, C Jarque, Christopher V. Rao, D Novo, D Sarkar, DJ Marchette, DR Parks, E Choy, E Lugli, F Hahne, F Hahne, F Hahne, G Finak, G Finak, G Luta, G McLachlan, H Zare, J Li, J Trotter, JA Hartigan, JA Hartigan, JM Irish, JP Baudry, K Lo, L Herzenberg, LM Maier, MC Minnotte, MY Cheng, MY Cheng, MY Cheng, N Aghaeepour, PM Hartigan, R Scheuermann, R Tibshirani, RR Brinkman, S Pyne, S Ray, S Ray, Saumyadipta Pyne, Surajit Ray, T Lin, T Lin   +46 more
core   +5 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Rabbit PrP Is Partially Resistant to in vitro Aggregation Induced by Different Biological Cofactors

Frontiers in Neuroscience, 2021
Prion diseases have been described in humans and other mammals, including sheep, goats, cattle, and deer. Since mice, hamsters, and cats are susceptible to prion infection, they are often used to study the mechanisms of prion infection and conversion ...
Juliana N. Angelli, Juliana N. Angelli, Yulli M. Passos, Julyana M. A. Brito, Jerson L. Silva, Yraima Cordeiro, Tuane C. R. G. Vieira, Tuane C. R. G. Vieira   +7 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Cofactor Fingerprinting with STD NMR to Characterize Proteins of Unknown Function: Identification of a Rare cCMP Cofactor Preference [PDF]

, 2004
Proteomics efforts have created a need for better strategies to functionally categorize newly discovered proteins. To this end, we have employed saturation transfer difference NMR with pools of closely related cofactors, to determine cofactor preferences.
Sem, Daniel, Yao, Huili
core   +1 more source

Regulators of complement activity mediate inhibitory mechanisms through a common C3b‐binding mode [PDF]

, 2016
Item does not contain ...
Atkinson, John P, Bertram, Paula, Forneris, Federico, Granneman, Joke CM, Gros, Piet, Hauhart, Richard, Lambris, John D, Lin, Zhuoer, Liszewski, M. Kathryn, Ricklin, Daniel, Sfyroera, Georgia, Tzekou, Apostolia, Volokhina, Elena, Wu, Jin, Xue, Xiaoguang   +14 more
core   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Linearizability conditions for 1:-5 Lotka-Volterra two-dimensional complex quartic systems

上海师范大学学报. 自然科学版, 2017
In this paper we investigate the linearizability problem for the planar Lotka-Volterra complex quartic systems which are 1:-5 linear systems perturbed by homogeneous polynomials of degree 4, that is to say, we consider systems of the form ẋ = x(1 ...
Hu Zhaoping, Zhang Chao
doaj   +1 more source

Automated analysis of oxidative metabolites [PDF]

, 1974
An automated system for the study of drug metabolism is described. The system monitors the oxidative metabolites of aromatic amines and of compounds which produce formaldehyde on oxidative dealkylation.
Furner, R. L.
core   +1 more source