Results 1 to 10 of about 166,204 (247)

Protein engineering of oxidoreductases utilizing nicotinamide-based coenzymes, with applications in synthetic biology

Synthetic and Systems Biotechnology, 2017
Two natural nicotinamide-based coenzymes (NAD and NADP) are indispensably required by the vast majority of oxidoreductases for catabolism and anabolism, respectively.
Rui Huang, Yi-Heng Percival Zhang, Zhiguang Zhu   +2 more
exaly   +3 more sources

Physiological metabolic analysis and process optimization of hypoxia in promoting coenzyme Q10 biosynthesis and accumulation in Rhodobacter sphaeroides HY01 [PDF]

Synthetic and Systems Biotechnology
Coenzyme Q10 fermentation by Rhodobacter sphaeroides (R. sphaeroides) is highly aerobic. However, its biosynthesis and accumulation are paradoxically induced under hypoxic conditions.
Bo Li, Yan Ge, Li Fu, Huanan Guo, Ali Mohsin, Junming Li, Jiequn Wu, Biqin Chen, Yingping Zhuang, Zejian Wang   +9 more
doaj   +2 more sources

Cobalamin Riboswitches Are Broadly Sensitive to Corrinoid Cofactors to Enable an Efficient Gene Regulatory Strategy

mBio, 2022
In bacteria, many essential metabolic processes are controlled by riboswitches, gene regulatory RNAs that directly bind and detect metabolites. Highly specific effector binding enables riboswitches to respond to a single biologically relevant metabolite.
Kristopher J. Kennedy, Florian J. Widner, Olga M. Sokolovskaya, Lina V. Innocent, Rebecca R. Procknow, Kenny C. Mok, Michiko E. Taga   +6 more
doaj   +1 more source

4,7-Dimethoxy-6-propyl-2H-1,3-benzodioxole-5-carbaldehyde

Molbank, 2023
A simple intermediate for the synthesis of methoxy-analogues of coenzymes Q with substituents having various chain lengths based on natural polyalkoxyallylbenzene apiol has been developed.
Dmitry V. Tsyganov, Victor V. Semenov
doaj   +1 more source

The parp-1 and bax genes as potential targets for treatment of the heart functioning impairments induced by type 1 diabetes mellitus

Endocrine Regulations, 2021
Objectives. The present study was designed to assess whether apoptosis-related genes as parp-1 and bax could be targets for treatment of diabetes mellitus and whether vitamin D may exert beneficial effects.
Kuchmerovska Tamara, Guzyk Mykhailo, Tykhonenko Tetiana, Yanitska Lesya, Pryvrotska Irina, Diakun Kateryna   +5 more
doaj   +1 more source

Metabolomic Analysis of Carbohydrate and Amino Acid Changes Induced by Hypoxia in Naked Mole-Rat Brain and Liver

Metabolites, 2022
Hypoxia poses a major physiological challenge for mammals and has significant impacts on cellular and systemic metabolism. As with many other small rodents, naked mole-rats (NMRs; Heterocephalus glaber), who are among the most hypoxia-tolerant mammals ...
Hang Cheng, Yiming (Amy) Qin, Rashpal Dhillon, James Dowell, John M. Denu, Matthew E. Pamenter   +5 more
doaj   +1 more source

Structural Basis for Allostery in PLP-dependent Enzymes

Frontiers in Molecular Biosciences, 2022
Pyridoxal 5′-phosphate (PLP)-dependent enzymes are found ubiquitously in nature and are involved in a variety of biological pathways, from natural product synthesis to amino acid and glucose metabolism.
Jenny U. Tran, Breann L. Brown, Breann L. Brown   +2 more
doaj   +1 more source

Diversification by CofC and Control by CofD Govern Biosynthesis and Evolution of Coenzyme F420 and Its Derivative 3PG-F420

mBio, 2022
Coenzyme F420 is a microbial redox cofactor that mediates diverse physiological functions and is increasingly used for biocatalytic applications. Recently, diversified biosynthetic routes to F420 and the discovery of a derivative, 3PG-F420, were reported.
Mahmudul Hasan, Sabrina Schulze, Leona Berndt, Gottfried J. Palm, Daniel Braga, Ingrid Richter, Daniel Last, Michael Lammers, Gerald Lackner   +8 more
doaj   +1 more source

Biological Catalysis and Information Storage Have Relied on N-Glycosyl Derivatives of β-D-Ribofuranose since the Origins of Life

Biomolecules, 2023
Most naturally occurring nucleotides and nucleosides are N-glycosyl derivatives of β-d-ribose. These N-ribosides are involved in most metabolic processes that occur in cells.
Katarzyna Wozniak, Krzysztof Brzezinski
doaj   +1 more source

Rumen Methanogenesis, Rumen Fermentation, and Microbial Community Response to Nitroethane, 2-Nitroethanol, and 2-Nitro-1-Propanol: An In Vitro Study

Animals, 2020
Nitroethane (NE), 2-nitroethanol (NEOH), and 2-nitro-1-propanol (NPOH) were comparatively examined to determine their inhibitory actions on rumen fermentation and methanogenesis in vitro.
Zhenwei Zhang, Yanlu Wang, Xuemeng Si, Zhijun Cao, Shengli Li, Hongjian Yang   +5 more
doaj   +1 more source