Results 21 to 30 of about 133,360 (260)

Protein Engineering for Nicotinamide Coenzyme Specificity in Oxidoreductases: Attempts and Challenges

open access: yesFrontiers in Microbiology, 2018
Oxidoreductases are ubiquitous enzymes that catalyze an extensive range of chemical reactions with great specificity, efficiency, and selectivity. Most oxidoreductases are nicotinamide cofactor-dependent enzymes with a strong preference for NADP or NAD ...
Andrea M. Chánique   +2 more
doaj   +1 more source

Analysis and Suggestions of Evaluation and Approval for Health Foods Containing Coenzyme Q10

open access: yesShipin gongye ke-ji, 2022
Coenzyme Q10 is a fat-soluble vitamin-like benzoquinone compound, which is synthesized endogenously from tyrosine in human body. It has many physiological functions, such as participating in ATP production capacity, scavenging free radicals and anti ...
Yu JIANG   +4 more
doaj   +1 more source

Impact of Chemical Analogs of 4-Hydroxybenzoic Acid on Coenzyme Q Biosynthesis: From Inhibition to Bypass of Coenzyme Q Deficiency

open access: yesFrontiers in Physiology, 2017
Coenzyme Q is a lipid that participates to important physiological functions. Coenzyme Q is synthesized in multiple steps from the precursor 4-hydroxybenzoic acid.
Fabien Pierrel
doaj   +1 more source

Effect of iron and silver nanoparticles on coenzyme Q10 production by Gluconobacter japonicus FM10

open access: yesIranian Journal of Microbiology, 2020
Background and Objectives: Coenzyme Q10 is an anti-aging agent whose demand is increasing progressively. There are various strategies used for increasing coenzyme Q10 production by microorganisms.
Foozieh Moghadami, Ramin Hosseini
doaj   +1 more source

Heart Failure—Do We Need New Drugs or Have Them Already? A Case of Coenzyme Q10

open access: yesJournal of Cardiovascular Development and Disease, 2022
Heart failure (HF) is a global epidemic that contributes to the deterioration of quality of life and its shortening in 1–3% of adult people in the world. Pharmacotherapy of HF should rely on highly effective drugs that improve prognosis and prolong life.
Krzysztof J. Filipiak   +3 more
doaj   +1 more source

Thiamine antagonists trigger p53-dependent apoptosis in differentiated SH-SY5Y cells

open access: yesScientific Reports, 2017
Accumulating evidences suggest that p53 is a key coordinator of cellular events triggered by oxidative stress often associated with the impairment in thiamine metabolism and its functions.
Sergiy Chornyy   +2 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Determination of the Effect of Coenzyme Q-10 on Spermatogenic Stem Cells by Immunohistochemical Techniques in Male Rats with Experimental Hypothyroidism

open access: yesCyprus Journal of Medical Sciences
BACKGROUND/AIMS: Testicular dysfunction has been reported in hypothyroidism. However, the effect of hypothyroidism on spermatogonial stem cells (SSCs) is not understood.
Hatice Nur Şeflek   +2 more
doaj   +1 more source

Isolation of an Enzyme-Coenzyme A Intermediate from Succinyl Coenzyme A-Acetoacetate Coenzyme A Transferase

open access: yesJournal of Biological Chemistry, 1967
Abstract An alkali-labile enzyme-coenzyme A intermediate has been isolated by molecular exclusion chromatography of succinyl-CoA-acetoacetate coenzyme A transferase after incubation with acetoacetyl-CoA or succinyl-CoA. Treatment of the intermediate with tritium-labeled sodium borohydride results in enzyme inactivation and incorporation of ...
L B, Hersh, W P, Jencks
openaire   +2 more sources

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

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