Results 181 to 190 of about 188,158 (291)

Genome‐Wide CRISPR Screen Reveals PIK3CA Inhibition Enhances Lipid Nanoparticle‐Mediated siRNA Delivery

Advanced Science, EarlyView.
A genome‐wide CRISPR screen and identifies PIK3CA as a key regulator of lipid nanoparticle (LNP) uptake is performed. Modulating PIK3CA with small‐molecule inhibitor BAY1082439 enhanced LNP uptake, siRNA delivery, and gene silencing in a variety of epithelial cells, and improved therapeutic outcomes in vivo.
Wenhan Wang, Kangfu Chen, Zongjie Wang
wiley   +1 more source

Pathogenicity patterns in cytochrome P450 family. [PDF]

Bioinform Adv
Špačková A, Kadášová N, Hutařová Vařeková I, Berka K.   +3 more
europepmc   +1 more source

Regulation of the p53 cofactor JMY

, 2003
Houda Boulahbel
openalex   +1 more source

A Modular Biosensor Platform for the Detection of Plastic Monomers and the Engineering of Promiscuous Amidases Toward Challenging Substrates

Advanced Science, EarlyView.
A luciferase is used as biosensor for aldehydes, produced enzymatically from different monomeric building blocks of plastics like polyurethanes (PUs). The screening platform is used to monitor esterase, amidase, and urethanase activity and to guide the selection of enzyme variants with improved hydrolytic activities toward difficult to hydrolyze ...
Ina Somvilla, Hannah Meier, Florian Oehlschläger, Hannes Meinert, Lena Koch, Patrick Ihrle, Katharina M. Mehnert, Morten Flieger, Jonas Boß, Marco Seifert, Dominique Böttcher, Uwe T. Bornscheuer, Thomas Bayer   +12 more
wiley   +1 more source

Particle on a Rod: Surface-Tethered Catalyst on CdS Nanorods for Enzymatically Active Nicotinamide Cofactor Generation [PDF]

L. Jayasinghe, J. Wei, Jin‐Hyun Kim, Elizabeth Lineberry, Peidong Yang   +4 more
openalex   +1 more source

Identification in vitro of an endothelial cell surface cofactor for antithrombin III. Parallel studies with isolated perfused rat hearts and microcarrier cultures of bovine endothelium. [PDF]

, 1982
C. Busch, Whyte G. Owen
openalex   +1 more source

Development of Dimethylsulfonium Probes for Broad Profiling of Methyllysine Reader Proteins

Advanced Science, EarlyView.
Development of oligoglycine‐based dimethylsulfonium probes for unbiased crosslinking to methyllysine readers. The general probe facilitates profiling of site‐specific methyllysine readers, evaluation of selectivity and activity of reader inhibitors, and global profiling of methyllysine readers.
Jinyu Yang, Yihang Xiao, Yingxiao Gao, Mingxuan Wu   +3 more
wiley   +1 more source

A Modular DNAzyme for Precise Visualization and Intervention of Alternative Splicing Isoforms in Live Cells

Advanced Science, EarlyView.
A Stringent dUPlex‐activated Error Robust (SUPER) DNAzyme system enables real‐time imaging of alternative mRNA splicing (e.g., Bcl‐xL/Bcl‐xS) in living cells via target‐triggered split‐DNAzyme reassembly and dual‐color fluorescence. It also achieves mRNA‐selective knockdown through DNAzyme‐based gene regulation, serving as a versatile tool for splicing
Mengru Lin, Jiale Sun, Yuqing Mao, Yuhao Tang, Fuan Wang, Zhihong Liu, Jing Wang   +6 more
wiley   +1 more source

Deserts, Rivers, Pools, and Billabongs: Water Features of the Nitrogenase Proteins, and their Functions. [PDF]

Chembiochem
Dance I.
europepmc   +1 more source

A Cellular CouplingStrategy Leveraging Pathway Modularizationand Cofactor Regeneration for the Biosynthesis of 3′-Sialyllactose

Zimeng Zhang (5635424), Hongtao Zhang (167639), Zhijie Wang (283745), Xing You (11352431), Yijie Mao (11406131), Zizhuo Li (6525656), Zhimeng Wu (1481236), Jianrong Wu (280398), Jianxin Zhao (640885), Wengang Chai (163394)   +9 more
openalex   +1 more source