Results 221 to 230 of about 188,158 (291)

Building Molecules by a Self‐Replicator That Catalyzes Acyl Hydrazone Formation

Angewandte Chemie, EarlyView.
A self‐replicator efficiently catalyzes the formation of acyl hydrazone bonds between a set of different substrates. In addition to previously reported (bond‐breaking) catalytic activity, this renders the self‐replicator highly promiscuous, which is a good starting point for Darwinian experiments en route to de‐novo life.
Kayleigh S. van Esterik, Tommaso Marchetti, Sijbren Otto   +2 more
wiley   +2 more sources

Proton transfer during reduction of the catalytic metallo-cofactors of the three nitrogenase isozymes. [PDF]

Chem Sci
Davydov R, Lukoyanov DA, Harris DF, Dean DR, Seefeldt LC, Hoffman BM.   +5 more
europepmc   +1 more source

Systematic Metabolic Engineering and Model‐Guided Optimization for High‐Level Production of L‐Theanine From Xylose in Escherichia Coli

Advanced Science, EarlyView.
This study is pioneering in constructing the shortest known synthetic pathway for L‐theanine production from xylose within E coli. Through comprehensive metabolic engineering strategies, our engineered strain achieved the highest reported L‐theanine titer from xylose, with a titer of 95.42 g/L, and a yield of 0.55 g/g.
Haolin Han, Boyuan Xue, Guangqi Shan, Meng Meng, Shaojie Wang, Haijia Su   +5 more
wiley   +1 more source

Growth, Dissolution and Segregation of Genetically Encoded RNA Droplets by Ribozyme Catalysis

Angewandte Chemie, EarlyView.
Ribozymes enable sequence‐encoded turnover of RNA droplet material, resulting in transiently active droplets that selectively segregate based on their genotype. This establishes a direct link between genetic information and droplet behavior, marking a step toward programmable, evolvable RNA‐based compartments with life‐like properties.
Franziska Giessler, William Verstraeten, Tobias Abele, Stefan J. Maurer, Luca Monari, Kerstin Göpfrich   +5 more
wiley   +2 more sources

Single-enzyme redox-neutral oxidation of alcohols to carboxylic acids using alcohol dehydrogenases.

Catal Sci Technol
Damian M, Wei Z, Tseliou V, Mutti FG.
europepmc   +1 more source

Inhibitors of GapN-dependent NADPH supply as potential lead compounds for novel therapeutics against <i>Streptococcus pyogenes</i>. [PDF]

Virulence
Schütt I, Einwohlt P, Wandinger AM, Teuffel J, Wirsing R, Hlawatschke BH, Fehlauer HL, Bothe S, Bader N, Monaci E, Kreikemeyer B, Schindelin H, Wade RC, Fiedler T.   +13 more
europepmc   +1 more source

Genetic and Phenotypic Features of the Five Known Polyaminopathies: A Critical Narrative Review

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Polyaminopathies are a recently described family of rare genetic neurodevelopmental disorders. Polyaminopathies disrupt the biosynthesis of the primary polyamines: putrescine, spermidine, and spermine. Snyder–Robinson syndrome results from hemizygous loss‐of‐function variants in the spermine synthase (SMS) gene, resulting in decreased or ...
Elizabeth A. VanSickle, Sara M. Sarasua, Tracy Lowe, Christopher L. Farrell, Luigi Boccuto, Charles Schwartz, Anthony E. Pegg, Angela Peron, Victor Faundes, Mythily Ganapathi, Wendy K. Chung, Alban Ziegler, Floris Hofstede, Clément Prouteau, Katharina Steindl, Colleen Olson, Orrin Devinsky, Teresa L. Mastracci, Robert A. Casero Jr., Tracy Murray Stewart, Susan Gilmour, Teri Koerner, Mary Jo Kutler, Surender Rajasekaran, Julianne Michael, André S. Bachmann, Caleb P. Bupp   +26 more
wiley   +1 more source

Biocatalytic Regioselective C‐Formylation of Resorcinol Derivatives

Angewandte Chemie, EarlyView.
An acyltransferase from Chromobacterium sphagni (CsATase) was identified that catalyzes the regioselective formylation of resorcinol substrates. The formylation of substituted resorcinol derivatives yielded mono‐formylated products with up to 99% conversion and up to 74% isolated yield.
Lilla Gal, Suresh Rohan, Anna Żądło‐Dobrowolska, Bianca Hilweg, Judith Müller, Kai Tittmann, Wolfgang Kroutil   +6 more
wiley   +2 more sources

Deletion of the <i>moe</i>A gene in <i>Flavobacterium</i> IR1 drives structural color shift from green to blue and alters polysaccharide metabolism. [PDF]

Elife
Escobar Doncel Á, Patinios C, Campos A, Walter Costa MB, Turkina MV, Murace M, Staals RHJ, Vignolini S, Dutilh BE, Ingham CJ.   +9 more
europepmc   +1 more source