Results 251 to 260 of about 419,459 (324)

The Sabatier principle governs the performance of self-sufficient heterogeneous biocatalysts for redox biotransformations.

Cell Rep Phys Sci
Diamanti E, Oliden-Sánchez A, Grajales-Hernández D, Andrés-Sanz D, Fernández-Marín R, Padro D, Ruíz-Cabello J, Zangi R, López-Gallego F.   +8 more
europepmc   +1 more source

Structural Modeling of NTPDase-Substrate Complexes Preserving Catalytic Experimental Features. [PDF]

ACS Omega
de Moraes JVB, Polêto MD, de Castro RB, Bressan GC, de S Vasconcellos R, Sévigny J, Fietto JR.   +6 more
europepmc   +1 more source

Reticular Chemistry: A Versatile Platform for Engineering Heterogenous Biocatalysts

Advanced Science, EarlyView.
Rational design of reticular‐based heterogeneous biocatalysts enables significant enhancement in enzyme activity recovery and even achieves catalytic performance beyond native enzymes. Abstract Reticular materials, including metal‐organic frameworks (MOFs), covalent organic frameworks (COFs), and hydrogen‐bonded organic frameworks (HOFs), have emerged ...
Si Liu, Peiji Deng, Qianfan Chen, Qijun Sun, Yanhan Wang, Hongyu Shi, Kang Liang   +6 more
wiley   +1 more source

Improving Cofactor Promiscuity of HMG-CoA Reductase from <i>Ruegeria pomeroyi</i> Through Rational Design. [PDF]

Biomolecules
Xue H, Huang Y, Shah AM, Wang X, Hu Y, Zhang L, Zhao ZK.   +6 more
europepmc   +1 more source

A Sirtuin‐1‐Targeted Gene‐Activating Tetrahedral DNA Attenuates Bladder Fibrosis by Restoring Mitophagy in Fibroblasts via the SIRT1‐FOXO3‐BNIP3 Axis

Advanced Science, EarlyView.
The SIRT1‐targeted saRNA‐delivering tetrahedral DNA (TSA) treatment effectively upregulates SIRT1 expression, which subsequently promotes FOXO3A deacetylation. This deacetylation event relieves FOXO3A's transcriptional repression on the BNIP3 gene, thereby initiating PINK1‐PARKIN‐dependent mitophagy.
Wei Wang, Ran Yan, Lede Lin, Lei Xiang, Xiaozhi Xia, Liao Peng, Xiaoshuai Gao, Jiawei Chen, Yang Xiong, Liang Zhou, Yunfeng Lin   +10 more
wiley   +1 more source

NADH‐Reductive Stress Induced by Dihydrolipoamide Dehydrogenase Activation Contributes to Cuproptosis

Advanced Science, EarlyView.
This study demonstrates a cuproptosis mechanism involving nicotinamide adenine dinucleotide (NADH)‐reductive stress in neural cells. Copper activates dihydrolipoamide dehydrogenase under mitochondrial pH, accumulating NADH. Copper also induces mitochondrial permeability transition pore opening, facilitating NADH translocation to the cytosol and ...
Si‐Yi Zhang, Xing‐Hua Ren, Cheng‐Hong Zhang, Zhan‐You Wang   +3 more
wiley   +1 more source

Direct coupling of lactate oxidation with butyryl-CoA formation via a canonical electron transfer flavoprotein in Fusobacterium nucleatum. [PDF]

J Biol Chem
Do LTM, Godin R, Wolthers KR.
europepmc   +1 more source

Research advancements and evaluation of multifactor‐induced murine models for gastric cancer

Animal Models and Experimental Medicine, EarlyView.
Murine models for gastric cancer. Abstract As one of the most prevalent gastrointestinal malignancies in humans, gastric cancer (GC) is often detected at an advanced stage, resulting in a poor prognosis and ranking it the fifth leading cause of cancer‐related deaths.
Yiqing Wang, Liang Zhang, Weixu Feng, Wanfeng Liu, Xiangyang Xue, Shiyu Feng   +5 more
wiley   +1 more source

Cofactor-independent photo-enzymatic reductions with water mediated by reductive graphene quantum dots. [PDF]

Nat Commun
Wang A, Li X, Qiao L, Pan X, Jiang Y, Wang Z, Ye W, Gao P, Sheldon RA.   +8 more
europepmc   +1 more source

Emergent Chemical Reactivity and Complexity of RNA Condensates

Angewandte Chemie, EarlyView.
RNA condensates capable of substrate enrichment and catalysis modulate their environment. Could this start a catalytic selection loop or evolution? Abstract The RNA world hypothesis posits the existence of life‐like assemblies that consisted mostly of RNA.
Samuel Hauf, Ryo Nakamura, Barbara Cellini, Yohei Yokobayashi, Mirco Dindo   +4 more
wiley   +1 more source