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Beyond Single Enzymes: System-Level Fungal Transformation of Halogenated Nitrophenols. [PDF]
Aguilar G +8 more
europepmc +1 more source
Kunihiro Hattori, Tomoyuki Igawa, and Takehisa Kitazawa share Lasker Award honors for revolutionary hemophilia A therapy. [PDF]
Flaumenhaft R.
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Cofactor squelching: Artifact or fact?
Cofactor squelching is the term used to describe competition between transcription factors (TFs) for a limited amount of cofactors in a cell with the functional consequence that TFs in a given cell interfere with the activity of each other. Since cofactor squelching was proposed based primarily on reporter assays some 30 years ago, it has remained ...
Susanne Mandrup +2 more
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Hierarchies of cofactor systems
Summary: We assign to any cofactor system a whole hierarchy of such systems. A sufficient condition for their complete integrability is given. The hierarchies admit construction of nontrivial integrable systems from trivial ones.
Topalov, P
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Novel cofactor derivatives and cofactor-based models
Current Opinion in Chemical Biology, 1998In 1997 and the first half of 1998, numerous publications appeared reporting studies of cofactors and their analogues in classical model systems and in enzyme-catalyzed reactions directed at understanding the enzymatic reactions of their natural cofactors. Model systems based on flavins have provided new insights into enzymatic modulation of the flavin
P K, Mishra, D G, Drueckhammer
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Cofactor dependent and cofactor independent anticardiolipin antibodies
Thrombosis Research, 1991Two distinct types of anticardiolipin antibodies are described, one of which requires the presence of a serum factor (cofactor) to bind cardiolipin in ELISA and liposome affinity systems. The second type does not require this cofactor. The requirement of a cofactor for the binding of some but not all anticardiolipin antibodies provides an explanation ...
L W, Chamley, E J, McKay, N S, Pattison
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2009
Cofactors are organic molecules, most of them originating from vitamins, that bind to enzymes making them able to catalyze defined reactions. A cofactor-based chemogenomics approach exploits the presence of a cofactor-binding domain to develop compound scaffolds tailored to mimic the cofactor and to replace it within target enzyme classes. As a result,
SINGH R, MOZZARELLI, Andrea
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Cofactors are organic molecules, most of them originating from vitamins, that bind to enzymes making them able to catalyze defined reactions. A cofactor-based chemogenomics approach exploits the presence of a cofactor-binding domain to develop compound scaffolds tailored to mimic the cofactor and to replace it within target enzyme classes. As a result,
SINGH R, MOZZARELLI, Andrea
openaire +2 more sources
Science, 2019
A mystery of bacterial chromosome segregation is explained by a nucleotide ...
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A mystery of bacterial chromosome segregation is explained by a nucleotide ...
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