Results 251 to 260 of about 230,804 (297)

Evaluation of cofactor responsiveness

Journal of Inherited Metabolic Disease, 1985
AbstractThe response to cofactor therapy in inborn errors of metabolism may be dramatic with complete resolution of the clinical illness but more commonly the response is absent or partial. When assessing cofactor responsiveness clinical and biochemical findings as well as the natural history of the disorder must be taken into account.
J V, Leonard, P, Daish
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Membrane cofactor protein

1992
MCP serves to down-regulate the activation of complement on host tissue. It performs this function by serving as a cofactor for the factor I-mediated cleavage of C3b and C4b. MCP is most likely an intrinsic regulator, i.e., it primarily protects its home cell.
M K, Liszewski, J P, Atkinson
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Molybdenum cofactor deficiency

The Journal of Pediatrics, 1993
We describe a new case of molybdenum cofactor deficiency, an underrecognized inborn error of metabolism that results in neonatal seizures and neurologic abnormalities. Characteristic biochemical defects in affected individuals include hypouricemia, elevated urine sulfate (detectable by dipstick), and elevated S-sulfocysteine (detectable by anion ...
G L, Arnold, C L, Greene, J P, Stout, S I, Goodman   +3 more
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Cofactor of the “Lupus Anticoagulant”

Thrombosis and Haemostasis, 1974
SummaryNormal plasma contains an activity known as cofactor which further lengthens the clotting time of the plasma of some patients with the “lupus anticoagulant.55 Cofactor has been characterized as either prothrombin or a gamma globulin. Our findings indicate that cofactor has the following properties: stable at room temperature but largely ...
G E, Rivard, S, Schiffman, S I, Rapaport
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The Cofactor Pyrroloquinoline Quinone

Annual Review of Nutrition, 1990
Article de synthese sur un cofacteur: la pyrroloquinoleine quinone. Etude de ses proprietes; caracteristiques, formes moleculaires, stabilite. Identification et analyse quantitative des formes libres, derivees et liees par liaison covalente. Distribution chez les procaryotes, les eucaryotes, les aliments et les boissons.
J A, Duine, R A, van der Meer, B W, Groen   +2 more
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Immobilized Cofactors and Cofactor Fragments in General Ligand Affinity Chromatography and as Active Cofactors

1978
It is known that many enzymes function only in conjunction with a coenzyme (cofactor) which is generally a compound of low molecular weight. Immobilization of these compounds has been the focus of much effort because of their potential as bioaffinity ligands and in the search for immobilized coenzymes retaining “biological activity”, which are readily ...
K. Mosbach, P.-O. Larsson
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Heparin Cofactor II

1997
Heparin cofactor II (HCII) is a serpin that inhibits thrombin rapidly in the presence of dermatan sulfate or heparin. Both of these glycosaminoglycans bind to HCII and increase the rate of inhibition of thrombin >1000-fold. This review will focus on the biochemistry of HCII and the mechanism by which glycosaminoglycans stimulate its activity.
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Biosynthesis of the methanogenic cofactors

2001
Our current knowledge of the pathways and genes involved in the biosynthesis of the methanogenic coenzymes methanopterin, coenzyme B, methanofuran, coenzyme F420, and coenzyme M is presented. Proposed reaction mechanisms for several of the novel reactions involved in the pathways are presented.
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Cofactor A

AfCS-Nature Molecule Pages, 2006
Guoling Tian, Nicholas Cowan
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Functionalised Cofactor Mimics for Interactome Discovery and Beyond

Angewandte Chemie - International Edition, 2022
Isabel V L Wilkinson, Stephan A. Sieber, Martin Pfanzelt   +2 more
exaly