Results 211 to 220 of about 2,155 (232)
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Temozolomide Cocrystals with Carboxamide Coformers
Crystal Growth & Design, 2013Temozolomide (TMZ) is an antitumor prodrug of broad spectrum antineoplastic activity. TMZ is stable in acidic medium (pH 7). In continuation of our efforts to design stable cocrystals of TMZ with partners such as organic acids (pKa 2–5) and a salt dihydrate with hydrochloric acid, we report herein TMZ cocrystals with amide coformers, e.g ...
Palash Sanphui +2 more
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Four cocrystals of thymine with phenolic coformers: influence of the coformer on hydrogen bonding
Acta Crystallographica Section C Structural Chemistry, 2015Cocrystals are molecular solids composed of at least two types of neutral chemical species held together by noncovalent forces. Crystallization of thymine [systematic name: 5-methylpyrimidine-2,4(1H,3H)-dione] with four phenolic coformers resulted in cocrystal formation,viz.catechol (benzene-1,2-diol) giving thymine–catechol (1/1), C5H6N2O2·C6H6O2, (I),
Balasubramanian, Sridhar +2 more
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Among the coformers and cocrystals
2023Cocrystals have emerged as an exciting avenue for altering the behavior of drugs and creating new patents or intellectual properties in the pharmaceutical industry. However, the preparation of pharmaceutical cocrystals remains relatively uncommon, presenting a potential field for innovation. The advantage of cocrystals lies in their ability to preserve
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Exploring potential coformers for oxyresveratrol using principal component analysis
International Journal of Pharmaceutics, 2020Oxyresveratrol (OXY) exhibits poor bioavailability due to its low solubility. Cocrystals are effective in improving solubility of OXY. In this study, principal component analysis (PCA) was employed for coformer selection using 5 variables (solubility parameter, logP, hydrogen bonding acceptor, hydrogen bonding donor and molecular volume).
Passaporn Ouiyangkul +2 more
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A new polymorph of the common coformer isonicotinamide
CrystEngComm, 2019A polymorph of the widely employed coformer isonicotinamide crystallizing in the space group Pca21 is described for the first time.
Alexios I. Vicatos, Mino R. Caira
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Coformer Screening Using Thermal Analysis Based on Binary Phase Diagrams
Pharmaceutical Research, 2014The advent of cocrystals has demonstrated a growing need for efficient and comprehensive coformer screening in search of better development forms, including salt forms. Here, we investigated a coformer screening system for salts and cocrystals based on binary phase diagrams using thermal analysis and examined the effectiveness of the method ...
Hiroyuki, Yamashita +3 more
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Multicomponent solids of diclofenac with pyridine based coformers
Journal of Molecular Structure, 2020Abstract The present study reports nine crystalline forms of diclofenac acid which include cocrystals, salts, salt-cocrystals and salt hydrates with pyridines and amines based coformers utilizing acid … pyridine synthon. All the solids were successfully prepared and structurally characterized through PXRD, ATR, DSC and single crystal XRD. The crystal
Pramod Kumar Goswami +2 more
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Expérience de coformation : « joindre les deux bouts »
SociographeCette contribution présente le projet « Faire avec » de coconstruction ; partir du diagnostic jusqu’à la coanimation, penser une formation continue sur la participation des personnes accompagnées, pour des professionnels du travail social. Cet article en reprend toutes les étapes : le « comment faire commun », les apports des membres du duo formatif ...
Clotilde Girier, Yasmina Younes
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Integrated smart actuator containing a monolithic coformed accelerometer
SPIE Proceedings, 1997A general need exists for inexpensive finite-area transducer arrays which intrinsically combine acoustic or vibration sensing with area actuation. Such combination transducers are particularly needed in active sound and vibration control and smart-materials applications.
Robert D. Corsaro +2 more
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