Results 91 to 100 of about 280,147 (323)

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

Developmental disruption of amygdala transcriptome and socioemotional behavior in rats exposed to valproic acid prenatally

Molecular Autism, 2017
Background The amygdala controls socioemotional behavior and has consistently been implicated in the etiology of autism spectrum disorder (ASD). Precocious amygdala development is commonly reported in ASD youth with the degree of overgrowth positively ...
Catherine E. Barrett, Thomas M. Hennessey, Katelyn M. Gordon, Steve J. Ryan, Morgan L. McNair, Kerry J. Ressler, Donald G. Rainnie   +6 more
doaj   +1 more source

Differences in Cerebral Structure Associated With Depressive Symptoms in the Elderly With Alzheimer’s Disease

Frontiers in Aging Neuroscience, 2020
Background: Alzheimer’s disease (AD) is characterized by global deterioration in multiple cognitive domains. In addition to cognitive impairment, depressive symptoms are common issues that trouble AD patients.
Yue Wu, Yue Wu, Xingqi Wu, Xingqi Wu, Qiang Wei, Qiang Wei, Qiang Wei, Kai Wang, Kai Wang, Kai Wang, Kai Wang, Yanghua Tian, Yanghua Tian, Yanghua Tian, and the Alzheimer’s Disease Neuroimaging Initiative   +14 more
doaj   +1 more source

The role of conceptual knowledge in understanding synaesthesia: Evaluating contemporary findings from a ‘hub-and-spoke’ perspective

Frontiers in Psychology, 2014
Synaesthesia is a phenomenon in which stimulation in one sensory modality triggers involuntary experiences typically not associated with that stimulation.
Rocco eChiou, Rocco eChiou, Anina N Rich, Anina N Rich   +3 more
doaj   +1 more source

Cognitive treatments for eating disorders.

Journal of Consulting and Clinical Psychology, 1993
Cognitive-behavioral therapy (CBT) is applicable to all eating disorders but has been most intensively studied in the treatment of bulimia nervosa (BN). CBT is designed to alter abnormal attitudes about body shape and weight, replace dysfunctional dieting with normal eating habits, and develop coping skills for resisting binge eating and purging.
Wilson, G, Fairburn, C
openaire   +3 more sources

From 2D to 3D gamma passing rate tolerance and action limits for patient‐specific quality assurance in volumetric‐modulated arc therapy

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Background Volumetric modulated arc therapy (VMAT) requires an accurate patient‐specific quality assurance (PSQA) program. In clinical practice, this is usually performed using the γ‐index and the two‐dimensional gamma passing rate (2D %GP). A three‐dimensional (3D) index incorporating the patient anatomy could be more useful for the 3D dose ...
Christos Zarros, George Patatoukas, Nikos Kollaros, Marina Chalkia, Andromachi Kougioumtzopoulou, Vasilios Kouloulias, Kalliopi Platoni   +6 more
wiley   +1 more source

Does dose calculation algorithm affect the dosimetric accuracy of synthetic CT for MR‐only radiotherapy planning in brain tumors?

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose This study compares the dosimetric accuracy of deep‐learning‐based MR synthetic CT (sCT) in brain radiotherapy between the Analytical Anisotropic Algorithm (AAA) and AcurosXB (AXB). Additionally, it proposes a novel metric to predict the dosimetric accuracy of sCT for individual post‐surgical brain cases.
Jeffrey C. F. Lui, Francis K. H. Lee, C. C. Law, James C. H. Chow   +3 more
wiley   +1 more source

A review of artificial intelligence in brachytherapy

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Artificial intelligence (AI) has the potential to revolutionize brachytherapy's clinical workflow. This review comprehensively examines the application of AI, focusing on machine learning and deep learning, in various aspects of brachytherapy.
Jingchu Chen, Richard L. J. Qiu, Tonghe Wang, Shadab Momin, Xiaofeng Yang   +4 more
wiley   +1 more source

The Impact of Self-Reported Hearing Difficulties on Memory Collaboration in Older Adults

Frontiers in Neuroscience, 2019
Cognitive scientists and philosophers recently have highlighted the value of thinking about people at risk of or living with dementia as intertwined parts of broader cognitive systems that involve their spouse, family, friends, or carers.
Amanda J. Barnier, Amanda J. Barnier, Celia B. Harris, Celia B. Harris, Thomas Morris, Thomas Morris, Paul Strutt, Paul Strutt, Greg Savage, Greg Savage   +9 more
doaj   +1 more source