Results 91 to 100 of about 530,549 (345)

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

Gait and cognition: mapping the global and discrete relationships in ageing and neurodegenerative disease [PDF]

, 2016
Recent research highlights the association of gait and cognition in older adults but a stronger understanding is needed to discern coincident pathophysiology, patterns of change, examine underlying mechanisms and aid diagnosis.
Bunce, Jennifer, Burn, David, Lord, Sue, Morris, Rosie, Rochester, Lynn   +4 more
core   +2 more sources

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

False recognition in behavioural variant frontotemporal dementia and Alzheimer’s disease – disinhibition or amnesia?

Frontiers in Aging Neuroscience, 2016
Episodic memory recall processes in Alzheimer’s disease (AD) and behavioural variant frontotemporal dementia (bvFTD) can be similarly impaired, whereas recognition performance is more variable.
Emma C Flanagan, Emma C Flanagan, Emma C Flanagan, Stephanie Wong, Stephanie Wong, Aparna Dutt, Sicong Tu, Maxime Bertoux, Maxime Bertoux, Muireann Irish, Muireann Irish, Muireann Irish, Olivier Piguet, Olivier Piguet, Olivier Piguet, Sulakshana Rao, John R Hodges, John R Hodges, John R Hodges, Amitabha Ghosh, Michael Hornberger, Michael Hornberger   +21 more
doaj   +1 more source

Decline and fall:a biological, developmental, and psycholinguistic account of deliberative language processes and ageing [PDF]

, 2011
Background: This paper reviews the role of deliberative processes in language: those language processes that require central resources, in contrast to the automatic processes of lexicalisation, word retrieval, and parsing.
Harley, Trevor A., Jessiman, Lesley J., MacAndrew, Siobhan B. G.   +2 more
core   +2 more sources

Identifying prognostic targets in metastatic prostate cancer beyond AR

FEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao   +13 more
wiley   +1 more source

Importance of the inverted control in measuring holistic face processing with the composite effect and part-whole effect.

Frontiers in Psychology, 2013
Holistic coding for faces is shown in several illusions that demonstrate integration of the percept across the entire face. The illusions occur upright but, crucially, not inverted.
Elinor eMcKone, Elinor eMcKone, Anne eAimola Davies, Anne eAimola Davies, Hayley eDarke, Kate eCrookes, Kate eCrookes, Tushara eWickramariyaratne, Stephanie eZappia, Chiara eFiorentini, Chiara eFiorentini, Simone eFavelle, Mary eBroughton, Dinusha eFernando   +13 more
doaj   +1 more source

Sensory over-responsivity and social cognition in ASD: Effects of aversive sensory stimuli and attentional modulation on neural responses to social cues. [PDF]

, 2018
Sensory over-responsivity (SOR) is a common condition in autism spectrum disorders (ASD) that is associated with greater social impairment. However, the mechanisms through which sensory stimuli may affect social functioning are not well understood.
Bookheimer, Susan Y, Bowman, Hilary C, Dapretto, Mirella, Green, Shulamite A, Hernandez, Leanna M   +4 more
core   +2 more sources

Earthing effects on mitochondrial function: ATP production and ROS generation

FEBS Open Bio, EarlyView.
In contrast to sham and naive controls, grounded mitochondria not only exhibit significantly enhanced energy production but also demonstrate a remarkable reduction in membrane potential and oxidative stress. This suggests a profound improvement in mitochondrial health, presenting a promising avenue for therapeutic interventions.
Cecilia Giulivi, Richard Kotz
wiley   +1 more source

Obesity-related alterations of intrinsic functional architecture: a resting-state fMRI study based on the human connectome project

Frontiers in Nutrition
BackgroundObesity, particularly in high-risk groups for food addiction, adversely impacts the brain’s functional characteristics. However, its underlying neurobiological and molecular mechanisms remain elusive.
Tongtong Wang, Todd Jackson, Matthew Lock, Hui Li, Jin Yan, Qian Zhuang, Shuaiyu Chen   +6 more
doaj   +1 more source