Results 101 to 110 of about 5,717,308 (331)

Code Red: Triage, Or, COgnition-based DEsign Rules Enhancing Decisionmaking TRaining In A Game Environment [PDF]

, 2011
Serious games have a great potential for training and educating people in novel and engaging ways. However, little empirical research has been done on the effectiveness of serious games, and although early findings do point to a moderately positive ...
van der Spek, E.D., Wouters, P.J.M., Sub Cognition & Communication begr., Cognition and Communication, van Oostendorp, H.   +4 more
core  

Mapping subtype-specific disease epicenters and brain aging characteristics in major depressive disorder through normative model-driven analysis of brain structural alterations

NeuroImage
Major depressive disorder (MDD), a prevalent mental health condition, manifests intricate alterations in brain structure that evolve gradually over time and across various brain regions.
Peng Wang, Yuhong Zheng, Li Sun, Yang Xiao, Xuelian Zang, Jinghua Wang, Jinhui Wang, Shao-Wei Xue   +7 more
doaj   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Importance of the inverted control in measuring holistic face processing with the composite effect and part-whole effect.

Frontiers in Psychology, 2013
Holistic coding for faces is shown in several illusions that demonstrate integration of the percept across the entire face. The illusions occur upright but, crucially, not inverted.
Elinor eMcKone, Elinor eMcKone, Anne eAimola Davies, Anne eAimola Davies, Hayley eDarke, Kate eCrookes, Kate eCrookes, Tushara eWickramariyaratne, Stephanie eZappia, Chiara eFiorentini, Chiara eFiorentini, Simone eFavelle, Mary eBroughton, Dinusha eFernando   +13 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Genetic contributions to visuospatial cognition in Williams syndrome: insights from two contrasting partial deletion patients [PDF]

, 2014
Background Williams syndrome (WS) is a rare neurodevelopmental disorder arising from a hemizygotic deletion of approximately 27 genes on chromosome 7, at locus 7q11.23.
Emily K Farran, Metcalfe, K., Turnpenny, P., Annette Karmiloff-Smith, Metcalfe, K, Tassabehji, May, Peter Turnpenny, Emma Meaburn, Karmiloff-Smith, A, Turnpenny, Peter D., Farran, E. K., Chin, E, Kay Metcalfe, Broadbent, H., Broadbent, Hannah, Tassabehji, M, Sansbury, F., Broadbent, H, Hannah Broadbent, Metcalfe, Kay, Farran, EK, Sansbury, Francis H., Chin, E., Turnpenny, Peter, Esther Chin, Meaburn, Emma L., Farran, E.K., Francis Sansbury, Turnpenny, P, Sansbury, Francis, Karmiloff-Smith, A., Meaburn, E, Sansbury, F, May Tassabehji, Karmiloff-Smith, Annette, Farran, Emily K, Tassabehji, M., Meaburn, E., Chin, Esther, Meaburn, Emma, Farran, Emily K.   +40 more
core   +1 more source

The role of conceptual knowledge in understanding synaesthesia: Evaluating contemporary findings from a ‘hub-and-spoke’ perspective

Frontiers in Psychology, 2014
Synaesthesia is a phenomenon in which stimulation in one sensory modality triggers involuntary experiences typically not associated with that stimulation.
Rocco eChiou, Rocco eChiou, Anina N Rich, Anina N Rich   +3 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Comparative cognition needs to focus more on outreach [PDF]

Finding support for the field of comparative cognition in an environment with a strong anthropocentric bent can be an uphill battle. Support may be strengthened via dissemination of findings outside typical academic channels, as they may demonstrate ...
Pinto, Carlos
core   +1 more source