Results 91 to 100 of about 5,717,308 (331)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Impaired Cognition and Brain Atrophy Decades After Hypertensive Pregnancy Disorders

Circulation. Cardiovascular Quality and Outcomes, 2016
Background—Hypertensive pregnancy disorders have been associated with subjective cognitive complaints or brain white-matter lesions 5 to 10 years after the hypertensive pregnancy.
M. Mielke, Natasa M. Milic, T. Weissgerber, Wendy M. White, K. Kantarci, T. Mosley, B. Windham, Brittany N. Simpson, S. Turner, Vesna D. Garovic   +9 more
semanticscholar   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Obesity-related alterations of intrinsic functional architecture: a resting-state fMRI study based on the human connectome project

Frontiers in Nutrition
BackgroundObesity, particularly in high-risk groups for food addiction, adversely impacts the brain’s functional characteristics. However, its underlying neurobiological and molecular mechanisms remain elusive.
Tongtong Wang, Todd Jackson, Matthew Lock, Hui Li, Jin Yan, Qian Zhuang, Shuaiyu Chen   +6 more
doaj   +1 more source

False recognition in behavioural variant frontotemporal dementia and Alzheimer’s disease – disinhibition or amnesia?

Frontiers in Aging Neuroscience, 2016
Episodic memory recall processes in Alzheimer’s disease (AD) and behavioural variant frontotemporal dementia (bvFTD) can be similarly impaired, whereas recognition performance is more variable.
Emma C Flanagan, Emma C Flanagan, Emma C Flanagan, Stephanie Wong, Stephanie Wong, Aparna Dutt, Sicong Tu, Maxime Bertoux, Maxime Bertoux, Muireann Irish, Muireann Irish, Muireann Irish, Olivier Piguet, Olivier Piguet, Olivier Piguet, Sulakshana Rao, John R Hodges, John R Hodges, John R Hodges, Amitabha Ghosh, Michael Hornberger, Michael Hornberger   +21 more
doaj   +1 more source

STROKOG (stroke and cognition consortium): An international consortium to examine the epidemiology, diagnosis, and treatment of neurocognitive disorders in relation to cerebrovascular disease

Alzheimer's & Dementia, 2016
The Stroke and Cognition consortium (STROKOG) aims to facilitate a better understanding of the determinants of vascular contributions to cognitive disorders and help improve the diagnosis and treatment of vascular cognitive disorders (VCD).
P. Sachdev, Jessica W. Lo, J. Crawford, L. Mellon, A. Hickey, David J. Williams, R. Bordet, A. Mendyk, P. Gele, D. Deplanque, H. Bae, Jae-Sung Lim, A. Brodtmann, E. Werden, T. Cumming, S. Köhler, F. Verhey, Yan-Hong Dong, H. Tan, C. Chen, Xu Xin, R. Kalaria, L. Allan, R. Akinyemi, A. Ogunniyi, A. Klimkowicz-Mrowiec, M. Dichgans, F. Wollenweber, V. Zietemann, Michael W. Hoffmann, D. W. Desmond, Thomas Linden, C. Blomstrand, B. Fagerberg, I. Skoog, O. Godefroy, M. Barbay, M. Roussel, Byung-Chul Lee, K. Yu, J. Wardlaw, S. Makin, F. Doubal, F. Chappell, V. Srikanth, A. Thrift, G. Donnan, N. Kandiah, Russell J Chander, Xuling Lin, C. Cordonnier, S. Moulin, Costanza Rossi, B. Sabayan, D. Stott, J. Jukema, S. Melkas, H. Jokinen, T. Erkinjuntti, V. Mok, A. Wong, B. Lam, D. Leys, H. Hénon, S. Bombois, D. Lipnicki, N. Kochan   +66 more
semanticscholar   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Social cognition in Williams Syndrome: genotype/phenotype insights from partial deletion patients [PDF]

, 2012
Identifying genotype/phenotype relations in human social cognition has been enhanced by the study of Williams syndrome (WS). Indeed, individuals with WS present with a particularly strong social drive, and researchers have sought to link deleted genes in
Kay eMetcalfe, Metcalfe, K., Annette Karmiloff-Smith, Senju, Atsushi, Peter Turnpenny, Wu, Racehl, Longhi, Elena, Happé, Francesca, Kay Metcalfe, Sansbury, F., Hannah Broadbent, Longhi, E, Metcalfe, Kay, Farran, EK, D'Souza, D, Happé, F., Turnpenny, Peter, Annette eKarmiloff-Smith, Wu, Rachel, Elena eLonghi, Longhi, E., Sansbury, Francis, Francesca eHappé, D'Souza, Dean, Farran, Emily, Elena Longhi, Tassabehji, M., Emily K. Farran, Turnpenny, P., Metcalfe, K, Tassabehji, May, Karmiloff-Smith, A, Dean eD'Souza, Broadbent, H., Broadbent, Hannah, Tassabehji, M, Atsushi Senju, Broadbent, H, Francis eSansbury, Rachel Wu, Wu, R, Peter eTurnpenny, May eTassabehji, Happé, F, Farran, E.K., Atsushi eSenju, Francis Sansbury, Turnpenny, P, Dean D’Souza, Francesca Happé, Senju, A, Hannah eBroadbent, Rachel eWu, Sansbury, F, May Tassabehji, Karmiloff-Smith, Annette, Farran, Emily K   +56 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source