Results 91 to 100 of about 594,485 (309)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Mapping subtype-specific disease epicenters and brain aging characteristics in major depressive disorder through normative model-driven analysis of brain structural alterations

NeuroImage
Major depressive disorder (MDD), a prevalent mental health condition, manifests intricate alterations in brain structure that evolve gradually over time and across various brain regions.
Peng Wang, Yuhong Zheng, Li Sun, Yang Xiao, Xuelian Zang, Jinghua Wang, Jinhui Wang, Shao-Wei Xue   +7 more
doaj   +1 more source

Hypoxia Augments Cerebral Inflammation in a Dextran Sulfate Sodium-Induced Colitis Mouse Model

Frontiers in Cellular Neuroscience, 2020
The importance of hypoxia in the pathophysiology of inflammatory bowel disease (IBD) is increasingly being realized; also, hypoxia seems to be an important accelerator of brain inflammation, as has been reported by our group and others.
Ying Han, Ying Han, Liping Ding, Xiang Cheng, Ming Zhao, Tong Zhao, Liang Guo, Xinyang Li, Yanan Geng, Yanan Geng, Ming Fan, Ming Fan, Hong Liao, Lingling Zhu, Lingling Zhu   +14 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

The role of conceptual knowledge in understanding synaesthesia: Evaluating contemporary findings from a ‘hub-and-spoke’ perspective

Frontiers in Psychology, 2014
Synaesthesia is a phenomenon in which stimulation in one sensory modality triggers involuntary experiences typically not associated with that stimulation.
Rocco eChiou, Rocco eChiou, Anina N Rich, Anina N Rich   +3 more
doaj   +1 more source

Genetic contributions to visuospatial cognition in Williams syndrome: insights from two contrasting partial deletion patients [PDF]

, 2014
Background Williams syndrome (WS) is a rare neurodevelopmental disorder arising from a hemizygotic deletion of approximately 27 genes on chromosome 7, at locus 7q11.23.
A Antonell, A Karmiloff-Smith, A Karmiloff-Smith, A Karmiloff-Smith, AD Smith, AE Richardson, Annette Karmiloff-Smith, B Landau, BR Pober, C Fusco, C Schubert, CA Morris, CC Hoogenraad, CD Elliott, D Voyer, D Wechsler, E Mellet, EJ Young, EK Farran, EK Farran, EK Farran, EK Farran, EK Farran, Emily K Farran, Emma Meaburn, Esther Chin, Francis Sansbury, G Vandeweyer, H Hirota, Hannah Broadbent, HJ Broadbent, HJ Broadbent, HR Purser, J Bullens, J Bullens, J Fenner, J Huttenlocher, J Raven, J Van Herwegen, JM Frangiskakis, JM Zacks, JR Crawford, JR Crawford, JR Pani, K Iglói, K Iglói, Kay Metcalfe, L Dai, LR Osborne, M Bayes, M Castelo-Branco, M Fayasse, M Hegarty, M Hegarty, M Kozhevnikov, M Nardini, M Nardini, M Tassabehji, M Tassabehji, MA Porter, May Tassabehji, N Newcombe, Peter Turnpenny, RN Shepard, U Bellugi, U Koehler, V Gray, Y Meng, Z Urban   +68 more
core   +3 more sources

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Developmental disruption of amygdala transcriptome and socioemotional behavior in rats exposed to valproic acid prenatally

Molecular Autism, 2017
Background The amygdala controls socioemotional behavior and has consistently been implicated in the etiology of autism spectrum disorder (ASD). Precocious amygdala development is commonly reported in ASD youth with the degree of overgrowth positively ...
Catherine E. Barrett, Thomas M. Hennessey, Katelyn M. Gordon, Steve J. Ryan, Morgan L. McNair, Kerry J. Ressler, Donald G. Rainnie   +6 more
doaj   +1 more source