Results 21 to 30 of about 280,147 (323)

Improving gait adaptability in patients with hereditary spastic paraplegia (Move-HSP): study protocol for a randomized controlled trial

Trials, 2021
Background People with hereditary spastic paraplegia (HSP) experience difficulties adapting their gait to meet environmental demands, a skill required for safe and independent ambulation.
Lotte van de Venis, Bart P. C. van de Warrenburg, Vivian Weerdesteyn, Bas J. H. van Lith, Alexander C. H. Geurts, Jorik Nonnekes   +5 more
doaj   +1 more source

Multiple sclerosis clinical decision support system based on projection to reference datasets

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1863-1873, December 2022., 2022
Abstract Objective Multiple sclerosis (MS) is a multifactorial disease with increasingly complicated management. Our objective is to use on‐demand computational power to address the challenges of dynamically managing MS. Methods A phase 3 clinical trial data (NCT00906399) were used to contextualize the medication efficacy of peg‐interferon beta‐1a vs ...
Chadia Ed‐driouch, Florent Chéneau, Françoise Simon, Guillaume Pasquier, Benoit Combès, Anne Kerbrat, Emmanuelle Le Page, Sophie Limou, Nicolas Vince, David‐Axel Laplaud, Franck Mars, Cédric Dumas, Gilles Edan, Pierre‐Antoine Gourraud   +13 more
wiley   +1 more source

A quasi-randomized feasibility pilot study of specific treatments to improve emotion recognition and mental-state reasoning impairments in schizophrenia

BMC Psychiatry, 2016
Background Impaired ability to make inferences about what another person might think or feel (i.e., social cognition impairment) is recognised as a core feature of schizophrenia and a key determinant of the poor social functioning that characterizes this
Pamela Jane Marsh, Vince Polito, Subba Singh, Max Coltheart, Robyn Langdon, Anthony W. Harris   +5 more
doaj   +1 more source

Study on mechanism of cerebral blood flow and cognitive impairment related to white matter hyperintensity

Chinese Journal of Contemporary Neurology and Neurosurgery, 2021
Objective To explore the relationship between alteration of cerebral blood flow (CBF) and cognitive impairment in patients with white matter hyperintensity (WMH).
LIU Yuan⁃yuan, CAO Shan⁃shan, HU Pan⁃pan, TIAN Yang⁃hua , WANG Kai, WEI Qiang   +5 more
doaj   +1 more source

Phenotypic continuum of NFU1‐related disorders

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 2025-2035, December 2022., 2022
Abstract Bi‐allelic variants in Iron–Sulfur Cluster Scaffold (NFU1) have previously been associated with multiple mitochondrial dysfunctions syndrome 1 (MMDS1) characterized by early‐onset rapidly fatal leukoencephalopathy. We report 19 affected individuals from 10 independent families with ultra‐rare bi‐allelic NFU1 missense variants associated with a
Rauan Kaiyrzhanov, Maha S. Zaki, Tracy Lau, Sambuddha Sen, Reza Azizimalamiri, Mina Zamani, Gözde Yeşil Sayin, Taru Hilander, Stephanie Efthymiou, Viorica Chelban, Ruth Brown, Kyle Thompson, Maria Irene Scarano, Jaya Ganesh, Kairgali Koneev, Ismail Musab Gülaçar, Richard Person, Dinara Sadykova, Yerdan Maidyrov, Tahereh Seifi, Aizhan Zadagali, Geneviève Bernard, Katrina Allis, Houda Zghal Elloumi, Amanda Lindy, Ehsan Taghiabadi, Sumit Verma, Rachel Logan, Brian Kirmse, Renkui Bai, Shaimaa M. Khalaf, Mohamed S. Abdel‐Hamid, Alireza Sedaghat, Gholamreza Shariati, Mahmoud Issa, Jawaher Zeighami, Hasnaa M. Elbendary, Garry Brown, Robert W. Taylor, Hamid Galehdari, Joseph J. Gleeson, Christopher J. Carroll, James A. Cowan, Andres Moreno‐De‐Luca, Henry Houlden, Reza Maroofian   +45 more
wiley   +1 more source

Intact unconscious processing of eye contact in schizophrenia

Schizophrenia Research: Cognition, 2016
The perception of eye gaze is crucial for social interaction, providing essential information about another person’s goals, intentions, and focus of attention.
Kiley Seymour, Gillian Rhodes, Timo Stein, Robyn Langdon   +3 more
doaj   +1 more source

Age ⁃ related differences in HKU ⁃ AHMU neuropsychological assessment among healthy crowds

Chinese Journal of Contemporary Neurology and Neurosurgery, 2021
Objective To explore age⁃related changes in cognitive function and establish a complete set of neuropsychological scales suitable for Chinese people. Methods From April 2018 to December 2020, a cross⁃sectional study and age stratified sampling method ...
HU Pan⁃pan , ZHOU Shan⁃shan, WU Xing⁃qi, TIAN Yang⁃hua, ZHU Chun⁃yan, WANG Kai   +5 more
doaj   +1 more source

A potential biomarker of cognitive impairment: The olfactory dysfunction and its genes expression

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1884-1897, December 2022., 2022
Abstract Objective Accumulation evidence has reported that olfactory impairment may be an essential clinical marker and predictor of mild cognitive impairment or Alzheimer's disease. Method Participants were enrolled in the population‐based, prospective study in Fuxin county, Liaoning province, China between 2019 and 2021.
Jiayi Song, Jiahui Xu, Wei Yuan, Ruixue Li, Hui Guo, Hanshu Gao, Cuiying Gu, Wenjing Feng, Yanan Ma, Haiqiang Guo, Zhaoqing Sun, Liqiang Zheng   +11 more
wiley   +1 more source

Vascular endothelial‐cadherin as a marker of endothelial injury in preclinical Alzheimer disease

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1926-1940, December 2022., 2022
Abstract Objective Endothelial dysfunction is an early and prevalent pathology in Alzheimer disease (AD). We here investigate the value of vascular endothelial‐cadherin (VEC) as a cerebrospinal fluid (CSF) marker of endothelial injury in preclinical AD.
Rawan Tarawneh, Rachel S. Kasper, Jessie Sanford, Chia‐Ling Phuah, Jason Hassenstab, Carlos Cruchaga   +5 more
wiley   +1 more source

Medial temporal lobe contributions to intra-item associative recognition memory in the ageing brain

Frontiers in Behavioral Neuroscience, 2014
Ageing is associated with a decline in episodic memory function. This is accompanied by degradation of and functional changes in the medial temporal lobe (MTL) which subserves mnemonic processing.
Marshall Axel Dalton, Marshall Axel Dalton, Marshall Axel Dalton, Sicong eTu, Sicong eTu, Sicong eTu, Michael eHornberger, Michael eHornberger, Michael eHornberger, John Russel Hodges, John Russel Hodges, John Russel Hodges, Olivier ePiguet, Olivier ePiguet, Olivier ePiguet   +14 more
doaj   +1 more source