Results 31 to 40 of about 282,431 (259)

Self referential and social cognition in adolscents with autistic spectrum disorder [PDF]

, 2012
A dominant social cognition model has construed the central socio-communicative impairments in Autistic Spectrum Disorders (ASDs) as deficits in understanding others’ minds- what other people know, intend, believe and feel.
Woods, Damian Joseph Lloyd
core  

Social Cognition in Autism and Other Neurodevelopmental Disorders : A Co-twin Control Study

, 2019
Alterations in social cognition (SC) are hypothesized to underlie social communication and interaction challenges in autism spectrum disorder (ASD). The aetiological underpinnings driving this association remain unclear.
Neufeld, J., Bölte, S., Kuja-Halkola, R., Cauvet, É., Van't Westeinde, A., Isaksson, Johan, Isaksson, Johan,, Lundin, K., Willfors, C.   +8 more
core   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

Genetic contributions to visuospatial cognition in Williams syndrome: insights from two contrasting partial deletion patients [PDF]

, 2014
Background Williams syndrome (WS) is a rare neurodevelopmental disorder arising from a hemizygotic deletion of approximately 27 genes on chromosome 7, at locus 7q11.23.
Emily K Farran, Metcalfe, K., Turnpenny, P., Annette Karmiloff-Smith, Metcalfe, K, Tassabehji, May, Peter Turnpenny, Emma Meaburn, Karmiloff-Smith, A, Turnpenny, Peter D., Farran, E. K., Chin, E, Kay Metcalfe, Broadbent, H., Broadbent, Hannah, Tassabehji, M, Sansbury, F., Broadbent, H, Hannah Broadbent, Metcalfe, Kay, Farran, EK, Sansbury, Francis H., Chin, E., Turnpenny, Peter, Esther Chin, Meaburn, Emma L., Farran, E.K., Francis Sansbury, Turnpenny, P, Sansbury, Francis, Karmiloff-Smith, A., Meaburn, E, Sansbury, F, May Tassabehji, Karmiloff-Smith, Annette, Farran, Emily K, Tassabehji, M., Meaburn, E., Chin, Esther, Meaburn, Emma   +39 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Are developmental disorders like cases of adult brain damage? Implications from connectionist modelling [PDF]

, 2002
It is often assumed that similar domain-specific behavioural impairments found in cases of adult brain damage and developmental disorders correspond to similar underlying causes, and can serve as convergent evidence for the modular structure of the ...
Thomas, Michael S.C., Thomas, MSC, Karmiloff-Smith, Annette, Karmiloff-Smith, A   +3 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Cognition in Schizophrenia Spectrum and Other Psychotic Disorders

, 2019
Cognitive impairments are present in patients with severe mental illness (SMI) at the time of the first psychotic episode. People with schizophrenia are more impaired across the lifespan compared to bipolar patients or patients with major depression ...
Strassnig, Martin, Harvey, Philip D
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source