Results 51 to 60 of about 282,431 (259)

Precis of neuroconstructivism: how the brain constructs cognition [PDF]

, 2007
Neuroconstructivism: How the Brain Constructs Cognition proposes a unifying framework for the study of cognitive development that brings together (1) constructivism (which views development as the progressive elaboration of increasingly complex ...
Johnson, Mark H., Johnson, M.H., Spratling, M, Westermann, Gert, Thomas, Michael S. C., Spratling, M.W., Thomas, M S C, Mareschal, D, Thomas, Michael S.C., Sirois, Sylvain, Mareschal, Denis, Johnson, M H, Siros, S, Spratling, Michael, Westermann, G, Thomas, M.S.C., make_name_string expected hash reference, Sirois, S, Sirois, S.   +18 more
core   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Dysfunctional hippocampal activity affects emotion and cognition in mood disorders [PDF]

, 2012
Mood disorders, such as major depressive disorder (MDD), bipolar disorder and generalized anxiety disorder usually comprise mood related as well as cognitive symptoms and the interaction between these symptoms is still not clear.
Lindskog, Maria, Gómez Galán, Marta, Magara, Salvatore, Femenía Cantó, Teresa   +3 more
core   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Wayfinding in autism spectrum disorders

, 2011
This study featured the use of ... a comprehensive battery [of tests], designed to assess general spatial ability as well as varieties of spatial cognition (including spatial navigation)
Ing, Natalia, Natalia Ing
core  

The relationship between navigation abilities and mental disorders: Poster [PDF]

, 2021
This study examined the relationship between aspects of navigational ability and behavioral traits associated with various mental disorders. We propose that navigational ability may utilize the same brain circuitry that has dysfunction in certain ...
Woodry, Robert, Chrastil, Elizabeth, Tranquada-Torres, Bailey, Hatamian, Nikki, Yee, Andre   +4 more
core  

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

The Effect of Maternal Multiple Micronutrient Supplementation on Cognition and Mood during Pregnancy and Postpartum in Indonesia: A Randomized Trial [PDF]

, 2012
Maternal caregiving capacity, which is affected in part by cognition and mood, is crucial for the health of mothers and infants. Few interventions aim to improve maternal and infant health through improving such capacity.
SUMMIT Study Group, Michael T Ullman, Husni Muadz (179305), Prado, Elizabeth L., Katherine J Alcock, Husni Muadz, Alcock, Katherine J, Shankar, Anuraj H., Muadz, Husni, Anuraj H. Shankar (179306), Anuraj H Shankar, Prado, Elizabeth L, Alcock, Katherine J., Michael T. Ullman (179303), Elizabeth L Prado, Elizabeth L. Prado (179301), Shankar, Anuraj H, Ullman, Michael T., Ullman, Michael T, Katherine J. Alcock (114048)   +19 more
core   +1 more source