Results 51 to 60 of about 594,485 (309)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Crying and feeding problems in infancy and cognitive outcome in preschool children born at risk : a prospective population study [PDF]

, 2009
Objective: To investigate whether regulatory problems, i.e., crying and feeding problems in infants > 3 months of age, predict cognitive outcome in preschool children born at risk even when controlled for confounding factors.
Alvarez, Anderson, Andrea Schreier, Anuntaseree, Arbuckle, Armstrong, Aylward, Bacharach, Bartram, Bauer, Baumeister, Becker, Becker, Beery, Beery, Bergman, Boekaerts, Bornstein, Brandt, Brandt, Braus, Breslau, Browne, Burgemeister, Burgemeister, Byrne, Böhm, Carvajal, Casaer, Casaer, Castellanos, Chatoor, Childers, Cohen, Dahl, DeGangi, DeGangi, Dieter Wolke, Dubowitz, Dunn, Egger, El-Faddagh, Frings, Gabriele Schmid, Gale, Golding, Gomez-Benito, Gray, Griffiths, Hair, Hanson, Hedegaard, Hiscock, Johnson, Khashan, Kiese, Kiese-Himmel, Klein, Klenberg, Kline, Laucht, Laucht, Laucht, Lepkin, Lindberg, Lindberg, Lindstam, Liu, Lou, Luiz, Lundqvist, Lundqvist-Persson, Marlow, McCall, McDermott, Minde, Mortensen, Nordberg, Northstone, Overman, Papousek, Papousek, Papousek, Peterson, Porges, Posner, Rao, Rees, Reijneveld, Reilly, Remschmidt, Renate Meyer, Richman, Riegel, Ryckman, Schermelleh-Engel, Scott, Skovgaard, St James-Roberts, St James-Roberts, St James-Roberts, St James-Roberts, Tabachnik, Thunström, Tirosh, Tong, Turkheimer, van der Wal, von Hofacker, von Hofacker, von Kries, Wake, Weinstock, West, Wolke, Wolke, Wolke, Wolke, Wolke, Wolke, Wolke, Wolke, Wolke, Wright, Wurmser, Wurmser, Wurmser   +126 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

The association between gray matter volume in the hippocampal subfield and antidepressant efficacy mediated by abnormal dynamic functional connectivity

Scientific Reports
An abnormality of structures and functions in the hippocampus may have a key role in the pathophysiology of major depressive disorder (MDD). However, it is unclear whether structure factors of the hippocampus effectively impact antidepressant responses ...
Changxiao Kuai, Jiayong Pu, Donglin Wang, Zhonglin Tan, Yan Wang, Shao-Wei Xue   +5 more
doaj   +1 more source

A cognitive account of belief: A tentative roadmap

Frontiers in Psychology, 2015
Over the past decades, delusions have become the subject of growing and productive research spanning clinical and cognitive neurosciences. Despite this, the nature of belief, which underpins the construct of delusions, has received little formal ...
Michael H Connors, Michael H Connors, Michael H Connors, Michael H Connors, Peter W Halligan, Peter W Halligan   +5 more
doaj   +1 more source

Males are more sensitive to reward and less sensitive to loss than females among people with internet gaming disorder: fMRI evidence from a card-guessing task

BMC Psychiatry, 2020
Background Many studies have found an interesting issue in the Internet gaming disorder (IGD): males are always observed to be the majority. However, there are little research to exploring the differences in the neural mechanisms between males and ...
Jialin Zhang, Yan Hu, Ziliang Wang, Min Wang, Guang-Heng Dong   +4 more
doaj   +1 more source

Common Ribs of Inhibitory Synaptic Dysfunction in the Umbrella of Neurodevelopmental Disorders

, 2018
The term neurodevelopmental disorder (NDD) is an umbrella term used to group together a heterogeneous class of disorders characterized by disruption in cognition, emotion, and behavior, early in the developmental timescale.
Hines, Rochelle M., Joya, Christina, Rodriguez, Rachel Ali   +2 more
core   +2 more sources

Psychopathology in Williams syndrome: the effect of individual differences across the lifespan [PDF]

, 2009
The present research aimed to comprehensively explore psychopathology in Williams syndrome (WS) across the lifespan and evaluate the relationship between psychopathology and age category (child or adult), gender and cognitive ability.
American Psychiatric Association, American Psychiatric Association, Helen F. Dodd, Jefferys D., Karmiloff-Smith A., Kaufman J., Melanie A. Porter, Mervis C. B., Pober B. R., Silverman W. K., Soni S., Switaj D. M., Woodcock R. W.   +12 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source