Results 61 to 70 of about 248,196 (298)

Identifying prognostic targets in metastatic prostate cancer beyond AR

FEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao   +13 more
wiley   +1 more source

Cognitive style in bipolar disorder [PDF]

British Journal of Psychiatry, 2005
BackgroundAbnormalities of cognitive style in bipolar disorder are of both clinical and theoretical importance.AimsTo compare cognitive style in people with affective disorders and in healthy controls.MethodSelf-rated questionnaires were administered to 118 individuals with bipolar I disorder, 265 with unipolar major recurrent depression and 268 ...
Jones L, Scott J, Haque S, Gordon-Smith K, Heron J, Caesar S, Cooper C, Forty L, Hyde S, Lyon L, Greening J, Sham P, Farmer A, McGuffin P, Jones I, Craddock N   +15 more
openaire   +5 more sources

Increased individual variability in functional connectivity of the default mode network and its genetic correlates in major depressive disorder

Scientific Reports
Major depressive disorder (MDD) is a highly heterogeneous psychiatric disorder characterized with considerable individual variability in clinical manifestations which may correspond to brain alterations including the default mode network (DMN).
Chi Yao, Peng Wang, Yang Xiao, Yuhong Zheng, Jiayong Pu, Yongwei Miao, Jinghua Wang, Shao-Wei Xue   +7 more
doaj   +1 more source

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

False recognition in behavioural variant frontotemporal dementia and Alzheimer’s disease – disinhibition or amnesia?

Frontiers in Aging Neuroscience, 2016
Episodic memory recall processes in Alzheimer’s disease (AD) and behavioural variant frontotemporal dementia (bvFTD) can be similarly impaired, whereas recognition performance is more variable.
Emma C Flanagan, Emma C Flanagan, Emma C Flanagan, Stephanie Wong, Stephanie Wong, Aparna Dutt, Sicong Tu, Maxime Bertoux, Maxime Bertoux, Muireann Irish, Muireann Irish, Muireann Irish, Olivier Piguet, Olivier Piguet, Olivier Piguet, Sulakshana Rao, John R Hodges, John R Hodges, John R Hodges, Amitabha Ghosh, Michael Hornberger, Michael Hornberger   +21 more
doaj   +1 more source

Cis‐unsaturated sphingolipids support growth of sphingoid base‐deficient yeast but impair plasma membrane integrity

FEBS Open Bio, EarlyView.
Sphingoid base structures, the sphingolipid backbones, vary among species. We established yeast cells in which the native sphingoid base was replaced with plant‐type bases containing cis or trans double bonds. This is, to our knowledge, the first eukaryotic model mostly composed of sphingolipids containing cis‐unsaturated sphingoid base, providing a ...
Takashi Higuchi, Saki Sugihara, Yohei Ishibashi, Kono Yushi, Hazuki Yamauchi, Motohiro Tani   +5 more
wiley   +1 more source

Microbial profile of the appendix niche in acute appendicitis: a novel sampling approach

FEBS Open Bio, EarlyView.
This study utilized a novel sampling method, ERAT (i.e. endoscopic retrograde appendicitis treatment)‐guided lumen aspiration, to obtain samples from the appendix, and shotgun metagenomic sequencing was performed for in situ characterization of the appendix microbiome in patients with acute appendicitis.
Huimin Ma, Mingfei Wang, Yanhu Feng, Wanqi Zhang, Wenbo Wang, Yanfeng Xie, Guixiang Kong, Jie Feng, Pengfei Wang, Qi Wang, Xiaojun Huang   +10 more
wiley   +1 more source

Importance of the inverted control in measuring holistic face processing with the composite effect and part-whole effect.

Frontiers in Psychology, 2013
Holistic coding for faces is shown in several illusions that demonstrate integration of the percept across the entire face. The illusions occur upright but, crucially, not inverted.
Elinor eMcKone, Elinor eMcKone, Anne eAimola Davies, Anne eAimola Davies, Hayley eDarke, Kate eCrookes, Kate eCrookes, Tushara eWickramariyaratne, Stephanie eZappia, Chiara eFiorentini, Chiara eFiorentini, Simone eFavelle, Mary eBroughton, Dinusha eFernando   +13 more
doaj   +1 more source

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

FEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu, Yanan Wei, Zekun Wu, Tianmu Zhang, DoHoon Lee, Hadi Najafi, Woo Jae Kim   +6 more
wiley   +1 more source

Obesity-related alterations of intrinsic functional architecture: a resting-state fMRI study based on the human connectome project

Frontiers in Nutrition
BackgroundObesity, particularly in high-risk groups for food addiction, adversely impacts the brain’s functional characteristics. However, its underlying neurobiological and molecular mechanisms remain elusive.
Tongtong Wang, Todd Jackson, Matthew Lock, Hui Li, Jin Yan, Qian Zhuang, Shuaiyu Chen   +6 more
doaj   +1 more source