Results 61 to 70 of about 589,703 (337)

The association between gray matter volume in the hippocampal subfield and antidepressant efficacy mediated by abnormal dynamic functional connectivity

Scientific Reports
An abnormality of structures and functions in the hippocampus may have a key role in the pathophysiology of major depressive disorder (MDD). However, it is unclear whether structure factors of the hippocampus effectively impact antidepressant responses ...
Changxiao Kuai, Jiayong Pu, Donglin Wang, Zhonglin Tan, Yan Wang, Shao-Wei Xue   +5 more
doaj   +1 more source

Design of the PERSPECTIVE study: PERsonalized SPEeCh Therapy for actIVE conversation in Parkinson’s disease (randomized controlled trial)

Trials, 2022
Objective To evaluate the effectiveness of personalized and home-based speech therapy on quality of life, intelligibility, and social participation for people with Parkinson’s disease (PD) who have a reduced intelligibility of speech.
J. J. L. Maas, N. M. De Vries, B. R. Bloem, J. G. Kalf   +3 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

What can developmental disorders tell us about the neurocomputational constraints that shape development? the case of Williams syndrome [PDF]

, 2003
The uneven cognitive phenotype in the adult outcome of Williams syndrome has led some researchers to make strong claims about the modularity of the brain and the purported genetically determined, innate specification of cognitive modules.
Karmiloff-Smith, Annette, Thomas, Michael S.C.   +1 more
core   +3 more sources

Impaired perception of facial motion in autism spectrum disorder [PDF]

, 2014
Copyright: © 2014 O’Brien et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source
Girges, C, Hill, H, Johnston, A, O'Brien, J, Spencer, J   +4 more
core   +10 more sources

The effects of impulsivity and proactive inhibition on reactive inhibition and the go process: insights from the stop signal task of vocal and manual responses

Frontiers in Human Neuroscience, 2015
This study measured proactive and reactive response inhibition and their relationships with self-reported impulsivity. We examined the domains of both vocal and manual responding using a stop signal task (SST) with two stop probabilities: high and low ...
Leidy Janeth Castro-Meneses, Leidy Janeth Castro-Meneses, Blake Warren Johnson, Paul Fredrick Sowman, Paul Fredrick Sowman   +4 more
doaj   +1 more source

Stress, asthenia and cognitive disorders

Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2022
Asthenia is a clinical syndrome that nearly any somatic and neurological pathologies can manifest with. Being is essence a defense mechanism that signals the depletion of energy resources, asthenia can become a pathological, extremely disabling condition, and even transform into a nosology of its own - the chronic fatigue syndrome, an immune-mediated ...
E.E. Vasenina, O.A. Gankina, O.S. Levin
openaire   +3 more sources

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Asymmetric Differences in the Gray Matter Volume and Functional Connections of the Amygdala Are Associated With Clinical Manifestations of Alzheimer’s Disease

Frontiers in Neuroscience, 2020
ObjectiveAsymmetry is a subtle but pervasive aspect of the human brain, which may be altered in several neuropsychiatric conditions. Magnetic resonance imaging (MRI) studies have reported that cerebral structural asymmetries are altered in Alzheimer’s ...
Xingqi Wu, Xingqi Wu, Yue Wu, Yue Wu, Zhi Geng, Zhi Geng, Shanshan Zhou, Shanshan Zhou, Shanshan Zhou, Ling Wei, Ling Wei, Ling Wei, Gong-Jun Ji, Gong-Jun Ji, Gong-Jun Ji, Yanghua Tian, Yanghua Tian, Yanghua Tian, Kai Wang, Kai Wang, Kai Wang, Kai Wang   +21 more
doaj   +1 more source

Study development and protocol for a cohort study examining the impact of baseline social cognition on response to treatment for people living with post-traumatic stress disorder [PDF]

, 2022
Chantelle Wiseman, Andrew D. Lawrence, Jonathan I. Bisson, James Hotham, Anke Karl, Stanley Zammit   +5 more
openalex   +1 more source