Results 41 to 50 of about 2,225,872 (200)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Measuring Regional Cohesion Effects of Large-scale Transport Infrastructure Investments: An Accessibility Approach. [PDF]

, 2008
Cohesion is considered one of the main policy goals both at a EU an national level. However, there is currently a lack of a common approach to measure cohesion effects of large-scale transport infrastructure investments.
López Suárez, Elena, Gutierrez, Javier, Gomez, Gabriel   +2 more
core   +1 more source

An OER Recommender System Supporting Accessibility Requirements

, 2022
Art. 57, 4 S.Open Educational Resources are becoming a significant source of learning that are widely used for various educational purposes and levels. Learners have diverse backgrounds and needs, especially when it comes to learners with accessibility ...
Kismihok, G., Elias, Mirette, Lohmann, Steffen, Auer, Sören, Tavakoli, M.   +4 more
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Spatial Complex Network Analysis and Accessibility Indicators: the Case of Municipal Commuting in Sardinia, Italy [PDF]

, 2011
In this paper a contribution is presented with respect to accessibility indicators modelling for commuters moving through the municipalities of Sardinia, in Italy.
Andrea De Montis, Caschili, Simone, De Montis, Andrea, Alessandro Chessa, Simone Caschili, Chessa, Alessandro, De Montis A   +6 more
core   +1 more source

Evaluating the Cognitive Accessibility of Acute Care Occupational Therapy Discharge Materials for Individuals with Intellectual and Developmental Disabilities

Journal of Acute Care Occupational Therapy
Background People with intellectual and/or developmental disabilities are more likely to have lower levels of health literacy than people without intellectual and/or developmental disabilities.
Caitlin Cannon, Ariel Schwartz
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Block-level accessibility data for transit-way evaluation in the Twin Cities metropolitan region, 2019

, 2019
The data are provided in 20 shapefiles. The shapefiles are segmented by the scenario comparison and the analysis day/time. The fields include the Census block-level 15-digit identifiers, baseline accessibility, alternative scenario accessibility, their ...
Owen, Andrew, Carlson, Kristin
core   +1 more source

Impact of web accessibility on cognitive engagement in individuals without disabilities: Evidence from a psychophysiological study.

PLoS ONE
Web accessibility features on websites are designed for individuals with disabilities that include low vision and cognitive impairments, but such features can benefit everyone.
Merve Ekin, Krzysztof Krejtz, Carlos Duarte, Letícia Seixas Pereira, Ann Marcus-Quinn, Izabela Krejtz   +5 more
doaj   +1 more source