Results 101 to 110 of about 350,055 (312)

Feasibility and Tolerability of Performing Portable MRI for Neurological Disorders in an Outpatient Neurology Clinic: A Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick, Nomin Enkhtsetseg, Joseph Sadok, Matheus Mochetti, Annabel Sorby Adams, Jennifer Guo, Cristina Trapaga Hacker, Isabella Gomez Hjerthen, Seungwon Lee, Siddharth Satish, Andrew S. Ham, Justin Hill, Denis Balaban, Kevin Kyle, Rebecca L. Gillani, Marcelo Matiello, Aleksandar Videnovic, Eric C. Klawiter, W. Taylor Kimberly, Farrah J. Mateen   +19 more
wiley   +1 more source

Cognitive Reserve and its Association with Cognitive Abilities and the Big Five [PDF]

, 2010
The present study explored the concept of cognitive reserve by using a testing-the-limits paradigm (Kliegl et al., 1989). 140 young (M = 22.8 years, range = 20-30) and 140 older (M = 67.3 years, range = 57-75) adults were provided with extensive retest ...
Emmert, Maria
core  

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Evolution of the Aging Brain Transcriptome and Synaptic Regulation

, 2008
Alzheimer's disease and other neurodegenerative disorders of aging are characterized by clinical and pathological features that are relatively specific to humans.
Dakin Kelly A., Isaacs Adrian, Prolla Tomas A., Pan, Y, Gabuzda Dana H., Geula Chengiz, Li, C, Jianbin Wang, Pan Ying, Wang, J, Dakin, KA, Bruce A Yankner, Adrian Isaacs, Ying Pan, Isaacs, A, Gabuzda, DH, Tao Lu, Yankner Bruce A., Cheng Li, Geula, C, Tomas A Prolla, Loerch, PM, Prolla, TA, Lu, T, Yankner, BA, Li Cheng, Wang Jianbin, Chengiz Geula, Kelly A Dakin, Dana H Gabuzda, Patrick M Loerch, Loerch Patrick M., Vann, JM, Lu Tao, Vann James M., James M Vann   +35 more
core   +1 more source

Digital biomarkers for brain health: passive and continuous assessment from wearable sensors

npj Digital Medicine
Continuous and scalable monitoring of cognition and affective states is critical for the early detection of brain health, which is currently limited by the burden of active assessments. This study investigated the potential of consumer-grade wearable and
Igor Matias, Maximilian Haas, Eric J. Daza, Matthias Kliegel, Katarzyna Wac   +4 more
doaj   +1 more source

Task-Irrelevant Novel Sounds have Antithetical Effects on Visual Target Processing in Young and Old Adults

Frontiers in Aging Neuroscience, 2017
In young adults, primary visual task processing can be either enhanced or disrupted by novel auditory stimuli preceding target events, depending on task demands.
Erich S. Tusch, Nicole C. Feng, Phillip J. Holcomb, Kirk R. Daffner   +3 more
doaj   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

Potential factors that may promote successful cognitive aging

, 2012
David E VanceCenter for Nursing Research, School of Nursing, Edward R Roybal Center for Translational Research in Aging and Mobility, University of Alabama at Birmingham (UAB), Birmingham, AL, USAAbstract: With the unprecedented number of older adults ...
Vance DE
core  

Regional differences in effects of APOE epsilon4 on cognitive impairment in non-demented subjects [PDF]

, 2011
Item does not contain fulltextBACKGROUND: The APOE epsilon4 allele is a risk factor for Alzheimer's disease (AD). APOE epsilon4 is common in non-demented subjects with cognitive impairment.
Tsolaki, M, M. Tsolaki, L. Spiru, Spiru, L., Scheltens, P., Verhey, F. R. J., Ewers, M, B. Vellas, R.W. Jones, Elias-Sonnenschein, LS, L. Frölich, Wilcock, G, Kehoe, P. G., Almkvist, O, Kehoe, P.G., Froelich, Lutz, Nobili, F, Olde Rikkert, M., Hampel, H, Verhey, F.R.J., M. Olde Rikkert, P.G. Kehoe, L. Minthon, Frisoni, GB, Elias-Sonnenschein, L.S., Lund University., Frisoni, G. B., P. Scheltens, Wahlund, L. -O., Jones, RW, Frölich, L, Spiru, L, M. Ewers, Wilcock, G., F.R.J. Verhey, Norberg, J., Froelich, L., Schelthens, P, J. Norberg, Vellas, B, Almkvist, Ove, Riqaud, AS, Almkvist, Ove,, G. Wilcock, Frolich, L., Hampel, H., L.-O. Wahlund, Lenoir, H., Norberg, Joakim,, H. Hampel, Minthon, Lennart,, L.S. Elias-Sonnenschein, Jones, R.W., O. Almkvist, F. Nobili, Soininen, H., Graff, C., Norberg, J, Rikkert, M. Olde, Olde Rikkert, M, G.B. Frisoni, NOBILI, FLAVIO MARIANO, Kehoe, PG, Vellas, B., Minthon, Lennart, Frisoni, Giovanni B., Ewers, M., Jones, R. W., Minthon, L, Frisoni, G.B., Minthon, L., Jones, Roy W., Rigaud, A. -S, Wahlund, L.O., Rigaud, A.S., Graff, Caroline, Rigaud, A. S., Visser, P.J., Lenoir, H, Visser, PJ, Wahlund, Lars-Olof, Rigaud, AS, P.J. Visser, H. Lenoir, Almkvist, O., Nobili, F., Graff, C, Frölich, Lutz, Visser, P. J., Tsolaki, M., Elias-Sonnenschein, L. S., Wahlund, L. -O, C. Graff, Wahlund, L. O., Wahlund, LO, Verhey, FR, Scheltens, P, A.-S. Rigaud, Rikkert, Marcel Olde, Soininen, H, Rigaud, A. -S., Elias Sonnenschein, L. S., H. Soininen   +102 more
core   +1 more source