Results 91 to 100 of about 2,676,425 (261)

Clinical Impact of NOTCH3 Variant Location After First Stroke in CADASIL

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Despite its monogenic origin, Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy exhibits marked variability in clinical expression and severity. Variants in the NOTCH3 gene, within epidermal growth factor‐like repeat domains 1–6 or 7–34, are known to influence disease onset, but their impact ...
Léa Aguilhon   +5 more
wiley   +1 more source

Other title: [Kansas Department on Aging Overview]

open access: yes, 2009
application/pdf; "March 11, 2009."; Presentation before the Kansas Legislature, Senate Ways and Means Subcommittee on the Kansas Department on Aging, by Secretary Kathy Greenlee, Kansas Department on Aging.Presentation discussing the Governor's budget ...
Greenlee, Kathy.
core   +1 more source

Comprehensive Characterization of 98 Chinese Cases of Genetic Creutzfeldt‐Jakob Disease With T188K Mutation

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li   +11 more
wiley   +1 more source

Be the voice. Take action. Tigether

open access: yes, 2012
Jan. 12, 2012-; "... A blog-like publication that connects interest Ohioans to news and information about issues affecting older Ohioans and the people who care for and serve them."; Not published Feb.-Nov. 2013.; Issue for Jan.
Western Reserve Area Agency on Aging   +1 more
core  

Evaluation of Digital Technologies for Home‐Based Assessment in People With Amyotrophic Lateral Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Digital technologies hold promise for transforming healthcare by enhancing personalized treatments and offer valuable opportunities to improve patient care. Here, we evaluated several novel, self‐administered, home‐based, digital endpoints for their association with corresponding conventional standard clinical measures (primary) in ...
Arne Mueller   +14 more
wiley   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Effects of Fast Simple Numerical Calculation Training on Neural Systems

open access: yesNeural Plasticity, 2016
Cognitive training, including fast simple numerical calculation (FSNC), has been shown to improve performance on untrained processing speed and executive function tasks in the elderly.
Hikaru Takeuchi   +6 more
doaj   +1 more source

[Coalition for Aging LGBT General Preparation Resources]

open access: yes
Coalition for Aging LGBT General Preparation Resources document from the Coalition for Aging LGBT Records (The Dallas Way)
Coalition for Aging LGBT
core  

Other title: Kansas State Advisory Council on Aging annual report, 1992; Other title: Kansas Advisory Council on Aging annual report, 1992 Other title: Title of report quoted from Council Chair's letter of transmittal to Governor Finney, et al.: 1992-93 Annual Report of the Kansas State Advisory Council on Aging

open access: yes, 1994
"I am happy to present to you the 1992-93 Annual Report of the Kansas State Advisory Council on Aging"."--[February 3, 1994 Cover letter from Charles Oldfather, Chair of the Council, to Governor Finney et al.]<br>Created in 1977 by the Kansas Act ...
Kansas Advisory Council on Aging.
core  

Sex‐Stratified Association of Regional Dopamine Transporter Binding With Disease Progression in Amyotrophic Lateral Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe   +7 more
wiley   +1 more source

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