Results 131 to 140 of about 350,055 (312)

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source

Lifespan Intellectual Factors, Genetic Susceptibility, and Cognitive Phenotypes in Aging : Implications for Interventions

, 2019
Along with rapid global population aging, the age-related cognitive disorders such as mild cognitive impairment (MCI) and dementia have posed a serious threat to public health, health care system, and sustainable economic and societal development of all ...
Wang, Yongxiang, Du, Yifeng, Qiu, Chengxuan,, Li, Juan, Qiu, Chengxuan   +4 more
core   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Chronic stress induced cognitive impairment in APP/PS-1 double transgenic mouse model of Alzheimer's disease

Chinese Journal of Contemporary Neurology and Neurosurgery, 2015
Objective  To observe the effect of chronic unpredictable mild stress (CUMS) on the cognitive function and brain morphological changes in APP/PS-1 mice, one of the genetic mouse models of Alzheimer's disease (AD), and to investigate the possible role of ...
Bing HAN, Yuan GENG, Li SHEN, Mei-yu SUN, Qian WANG, Ming-wei WANG   +5 more
doaj  

Investigating biological sex as a moderator of the association of nature exposure with brain health: a cross-sectional UK biobank analysis

Scientific Reports
In this cross-sectional analysis of the UK Biobank, we investigated whether biological sex moderates the association of residential nature exposure with brain volume or cognitive function.
Matt Noseworthy, Ryan S. Falck, Liisa A. M. Galea, Todd C. Handy, Teresa Liu-Ambrose   +4 more
doaj   +1 more source

The ‘active reciprocity’ ecosystem: senior cohousing as a determinant of social support and cognitive vitality independent of socioeconomic status

Frontiers in Public Health
IntroductionThis study aims to explore the relationship between residential context and health-related outcomes. It seeks to analyze the differences in sociodemographic profiles, health status, psychosocial well-being, and cognitive performance between ...
María Luisa Delgado-Losada, María Luisa Delgado-Losada, Beatriz Sequeira-Villatoro, Beatriz Sequeira-Villatoro, Celia Alcaide-Prieto, Celia Alcaide-Prieto, Jaime Bouhaben, Jaime Bouhaben, Alice Delgado-Ramos, Alice Delgado-Ramos   +9 more
doaj   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Cognitive Abilities and Portfolio Choice [PDF]

We study the relation between cognitive abilities and stockholding using the recent Survey of Health, Ageing and Retirement in Europe (SHARE), which has detailed data on wealth and portfolio composition of individuals aged 50+ in 11 European countries ...
Mario Padula, Tullio Jappelli, Dimitris Christelis   +2 more
core  

Clinical Outcomes of SEEG‐Guided Radiofrequency Thermocoagulation in Children With Focal Drug‐Resistant Epilepsy: A Multicenter Real‐World Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) has emerged as a safe and effective minimally invasive treatment for children with drug‐resistant focal epilepsy. Although evidence from real‐world studies remains limited, numerous pediatric cases have demonstrated promising outcomes. This retrospective
Weitao Chen, Stéphane Jean, Weihong Liu, Yihai Dai, Xinrong Fang, Xiaoqiang Wei, Shan Chen, Shiwei Song   +7 more
wiley   +1 more source

Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone, Freddy Chafota, Miguel E. Rentería, Randi J. Hagerman, Ellery Santos, Anna Atkinson, Nicholas G. Martin, Elsdon Storey, Danuta Z. Loesch   +8 more
wiley   +1 more source