Results 41 to 50 of about 271,493 (253)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The importance of familial risk factors in children with ADHD: direct and indirect effects of family adversity, parental psychopathology and parenting practices on externalizing symptoms

Child and Adolescent Psychiatry and Mental Health, 2022
Background Children experiencing unfavorable family circumstances have an increased risk of developing externalizing symptoms. The present study examines the direct, indirect and total effects of family adversity, parental psychopathology, and positive ...
Lea Teresa Jendreizik, Christopher Hautmann, Elena von Wirth, Christina Dose, Ann-Kathrin Thöne, Anne-Katrin Treier, Tobias Banaschewski, Katja Becker, Daniel Brandeis, Julia Geissler, Johannes Hebebrand, Sarah Hohmann, Martin Holtmann, Michael Huss, Thomas Jans, Anna Kaiser, Sabina Millenet, Luise Poustka, Priska Schneider, Manfred Döpfner   +19 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Acceptance and utilization of web-based self-help for caregivers of children with externalizing disorders

Child and Adolescent Psychiatry and Mental Health
Background Web-based self-help interventions for parents of children with ADHD and other externalizing disorders have been proven to be effective. In order to recommend individualized and optimized interventions, a better understanding of the acceptance ...
Laura Wähnke, Julia Plück, Mikel Bodden, Angela Ernst, Marie-Theres Klemp, Judith Mühlenmeister, Manfred Döpfner   +6 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Psychosocial characteristics and daily impairment in women with persistent perinatal depressive symptoms: A large-scale cohort study

Journal of Affective Disorders Reports
Background: This study aimed to determine the prevalence of persistent perinatal depressive symptoms and to identify the psychosocial characteristics associated with persistent symptoms among Japanese women.
Haruna Irino, Satoko Sasagawa, Chika Yokoyama, Aiko Okatsu, Ayako Kanie, Chika Kubota, Yasue Mitamura, Sayaka Aoyama, Miyuki Makino, Aiichiro Nakajima, Yaeko Kataoka, Masaru Horikoshi, Hironori Kuga, Masaya Ito   +13 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Estructura Factorial Preliminar de la Escala de Creencias de Mujeres de O´Kelly en Población Mexicana

Avances en Psicología Latinoamericana, 2011
La versión mexicana de la australiana o’Kelly Women’s Belief scales fue administrada a una muestra de 363 mujeres nacidas y residentes en México. el análisis factorial con rotación varimax y con autovalor de 3 mostró 36 reactivos de los 92 originales en ...
Arturo Heman Contreras, Leonor Lega, Margarita Villaseñor Ponce, Ana Paulina Alva Jimenez, Lorena Garcia Guerrero   +4 more
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