Results 71 to 80 of about 2,848,161 (301)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Transient and selective effects of acute exercise intensity on response inhibition: an EEG study

Frontiers in Human Neuroscience
Acute aerobic exercise can transiently influence cognitive control, but how exercise intensity and recovery timing shape response inhibition and its neural correlates remains insufficiently understood.
Masaki Takayose, Masaki Takayose, Ryo Koshizawa, Kazuma Oki, Christina Thunberg, René J. Huster   +5 more
doaj   +1 more source

Behavioral and electrophysiological correlates of cognitive control in ex-obese adults [PDF]

, 2017
Impaired cognitive control functions have been documented in obesity. It remains unclear whether these functions normalize after weight reduction. We compared ex-obese individuals, who successfully underwent substantial weight loss after bariatric ...
Bassetto, Franco, Pavan, Chiara, Tarantino, Vincenza, Vallesi, Antonino, Vindigni, Vincenzo   +4 more
core   +1 more source

Motivation and Cognitive Control in Depression [PDF]

Neuroscience & Biobehavioral Reviews, 2018
Abstract Depression is linked to deficits in cognitive control and a host of other cognitive impairments arise as a consequence of these deficits. Despite of their important role in depression, there are no mechanistic models of cognitive control deficits in depression.
Grahek, Ivan, Shenhav, Amitai, Musslick, Sebastian, Krebs, Ruth M., Koster, Ernst H.W.   +4 more
openaire   +5 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Consciosusness in Cognitive Architectures. A Principled Analysis of RCS, Soar and ACT-R [PDF]

, 2008
This report analyses the aplicability of the principles of consciousness developed in the ASys project to three of the most relevant cognitive architectures.
Hernandez, Carlos, Lopez, Ignacio, Sanz, Ricardo   +2 more
core  

An architecturally constrained model of random number generation and its application to modeling the effect of generation rate [PDF]

, 2014
Random number generation (RNG) is a complex cognitive task for human subjects, requiring deliberative control to avoid production of habitual, stereotyped sequences. Under various manipulations (e.g., speeded responding, transcranial magnetic stimulation,
Anderson, Anderson, Baddeley, Baddeley, Baddeley, Baddeley, Baddeley, Bar-Hillel, Boucher, Brown, Cooper, Cooper, Cooper, Cooper, Cooper, Evans, Fletcher, Frith, Gilbert, Ginsburg, Jahanshahi, Jahanshahi, Jahanshahi, Laird, Luria, Meyer, Miyake, Newell, Nickerson, Norman, O'Reilly, Page, Philipp, Shallice, Shallice, Shallice, Sood, Spatt, Swick, Towse, Towse, Verbruggen, Verbruggen   +42 more
core   +2 more sources

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Is conflict adaptation triggered by feature repetitions? An unexpected finding [PDF]

, 2015
For decades, cognitive adaptation to response conflict has been considered to be the hallmark of cognitive control. Notwithstanding a vast amount of evidence ruling out low-level interpretations of these findings, disbelief still exists with regard to ...
Desender, Kobe, Van den Bussche, Eva, Van Lierde, Elke   +2 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source