Results 141 to 150 of about 970,204 (258)

A Lightweight Procedural Layer for Hybrid Experimental–Computational Workflows in Materials Science

Advanced Engineering Materials, EarlyView.
We unveil a prototype hybrid‐workflow framework that fuses automatedcomputation with hands‐on experiments. Built atop pyiron, a lightweight, parameterized layer translates procedure descriptions into executable manual steps, syncing instrument settings, human interventions, and data capture in real‐time today.
Steffen Brinckmann, Sarath Menon, Raphael Röske, Johannes Steinhülb, Michael Selzer, Jan Janssen, Tilmann Hickel, Ruth Schwaiger, Jörg Neugebauer   +8 more
wiley   +1 more source

The best treatment is prevention: prevention of cognitive decline and dementia - current state, gaps and next steps. [PDF]

Neurol Res Pract
Reetz K, Liepelt-Scarfone I, Häger A, Flöel A, Schulz JB, Dementia Commission of the German Society for Neurology (DGN).   +5 more
europepmc   +1 more source

Multi‐Scale Interface Engineering of MXenes for Multifunctional Sensory Systems

Advanced Functional Materials, EarlyView.
MXenes, as two‐dimensional transition metal carbides and nitrides, demonstrate remarkable capabilities for multifunctional sensing applications. This review systematically examines multi‐scale interface engineering approaches that enhance sensing performance, enable diverse detection functionalities, and improve system‐level compatibility in MXene ...
Jiaying Liao, Sin‐Yi Pang, Jianhua Hao
wiley   +1 more source

Accelerated epigenetic aging as a modifier of homocysteine-associated cognitive decline: Findings from NHANES. [PDF]

Alzheimers Dement
Li H, Chen Y, Wang Z, Wang Y, Bi R, Hou J, Chen H, Zhang Z, Guo Z, Chen Z, Cui H, Li S.   +11 more
europepmc   +1 more source

Small Extracellular Vesicles from Neural Cells: Physiological and Pathological Roles, and Potential in Neurodegenerative Therapy

Advanced Healthcare Materials, EarlyView.
Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey Collins‐Praino, Yuling Wang, Andrew Care   +4 more
wiley   +1 more source

Optoelectrical Devices for Neural Interfacing: Engineering Integration, Stability, and Multimodal Sensing

Advanced Healthcare Materials, EarlyView.
Implantable optoelectrical devices are an effective resource for the modulation and monitoring of neural activity with high spatiotemporal resolution. This review discusses current challenges faced by these devices and outlines future perspectives for the development of next‐generation neural interfaces targeting chronic, multisite, and multimodal ...
Stella Aslanoglou, Barbara Spagnolo, Antonio Balena, Massimo De Vittorio, Ferruccio Pisanello   +4 more
wiley   +1 more source

Genetic modifiers of APOE-ε4-associated cognitive decline. [PDF]

Nat Commun
Contreras AG, Walters S, Eissman JM, Archer DB, Regelson AN, Durant A, Clifton M, Mukherjee S, Lee ML, Choi SE, Scollard P, Trittschuh EH, Mez J, Bush WS, Kunkle BW, Cruchaga C, Naj AC, Gifford KA, Bilgel M, Kuzma AB, Alzheimer’s Disease Neuroimaging Initiative (ADNI), Alzheimer’s Disease Genetics Consortium (ADGC), Alzheimer’s Disease Sequencing Project (ADSP), Cuccaro ML, Pericak-Vance MA, Farrer LA, Wang LS, Schellenberg GD, Haines JL, Jefferson AL, Kukull WA, Keene CD, Saykin AJ, Thompson PM, Martin ER, Albert MS, Johnson SC, Engelman CD, Ferrucci L, Bennett DA, Barnes LL, Schneider JA, Sperling RA, Resnick SM, Crane PK, Dumitrescu L, Hohman TJ.   +46 more
europepmc   +1 more source

A Long‐Lived Human Neurovascular PENTA Culture Model Captures Incomplete Vascular Repair and Glia‐Associated Signaling After Traumatic Brain Injury

Advanced Healthcare Materials, EarlyView.
A long‐lived, five‐cell‐type human neurovascular (PENTA) model recreates vascular disorganization and incomplete repair after traumatic brain injury (TBI). By integrating endothelial, glial, neuronal, and immune components within a 3D scaffold, the platform enables time‐resolved analysis of neurovascular remodeling and provides a human‐relevant system ...
Daniel S. Hinrichsen, Sunghyun Jun, Colleen M. Arrasmith, Charitha C. Anamala, Mitchell D. Thielen, Anapaula Garcia, Volha Liaudanskaya   +6 more
wiley   +1 more source

Intestinal interoceptive dysfunction drives age-associated cognitive decline. [PDF]

Nature
Cox TO, Devason AS, de Araujo A, Mason S, Subramanian M, Salvador AFM, Descamps HC, Kim J, Zhu Y, Litichevskiy L, Jung S, Song WS, Cortés-Martín A, Henderson NT, Huang KP, Nguyen T, Sae-Lee W, Umana IC, Sacta M, Rahman RJ, Wisser S, Nelson JAD, Golynker I, McSween AM, Hohmann EF, Patel S, Bub AL, Soekler C, Blank N, Hoxha K, Boccia L, Wong AC, Bahnsen K, Kim J, Biderman N, Abbasian D, Shoffler C, Petucci C, McAllister FE, Alhadeff AL, Fuccillo MV, Hill C, Jang C, Betley JN, de Lartigue G, Lee VY, Levy M, Thaiss CA.   +47 more
europepmc   +1 more source

Designed Liquid Crystalline Nanoassemblies From Clinically Validated Polyunsaturated Lipids for Combined Antioxidant, Anti‐Apoptotic, and Neurotrophic Treatments

Advanced Healthcare Materials, EarlyView.
Ionizable lipid nanoparticles target multiple pathological pathways in neurodegeneration. The designed self‐assembled materials undergo a pH‐triggered structural transformation from a cubosome/hexosome coexistence to a hexosome phase, enhancing intracellular delivery of a multi‐target phytochemical formulation. The antioxidant‐loaded pH‐responsive LNPs
Thelma Akanchise, Fucen Luo, Borislav Angelov, Yuru Deng, Angelina Angelova   +4 more
wiley   +1 more source