Results 181 to 190 of about 970,204 (258)

Ultrasound Modulation of Visual Circuits in Mice Independent of Auditory Confound

Advanced Science, EarlyView.
In this study, Qiu et al. found that low‐intensity ultrasound can directly activate sparse ultrasound‐sensitive neurons (UNs) in the primary visual cortex (V1) of deafened mice. The proportion of these sparse UNs is pressure‐dependent. Furthermore, ultrasound modulates visual circuitry with distinct excitatory and inhibitory effects.
Jiaru He, Jiejun Zhu, Xinxin Wang, Zihao Chen, Jin Yang, Zhen Yuan, Hongzhi Xu, Lei Sun, Zhihai Qiu   +8 more
wiley   +1 more source

Association of neurogenic orthostatic hypotension with cognitive decline in Parkinson's disease: a longitudinal cohort study. [PDF]

Front Neurol
Bagheri N, Longardner K, Coughlin D.
europepmc   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Glymphatic dysfunction links vascular pathology to Alzheimer's biomarkers and cognitive decline. [PDF]

Alzheimers Res Ther
Kang SH, Kim S, Kim YJ, Yoo H, Lee EH, Jang H, Shin D, Yun J, Kim JP, Kim HJ, Na DL, Zetterberg H, Blennow K, Gonzalez-Ortiz F, Ashton NJ, Day TA, Duering M, Koh SB, Kim SY, Kim EY, Kim ST, Sohn B, Seo SW.   +22 more
europepmc   +1 more source

Intracellular Aβ42 Sequestration by a Serine Protease Mitigates Neurotoxicity in a Drosophila Alzheimer's Disease Model

Advanced Science, EarlyView.
Emerging evidence suggests that intraneuronal Aβ accumulation represents an early pathogenic event in Alzheimer's disease (AD). Using Drosophila AD model, this study shows that a nonsecreted serine protease Yip7 physically interacts with Aβ. This causes intraneuronal Aβ accumulation but surprisingly reduces the associated neurotoxicity, arguing that ...
Jingyun Su, Meng Yang, Xinfeng Wang, Pa Wu, Zongzhao Zhai   +4 more
wiley   +1 more source

Resilience Shields and Grit Intensifies Subjective Cognitive Decline in Middle-To-Older Aged Black Americans. [PDF]

Int J Geriatr Psychiatry
Folorunsho S, Clark M, Odo O, Jackson YL, Nwakasi C, Esiaka DK.   +5 more
europepmc   +1 more source

Associations of Blood Pressure Parameters with Cognitive Decline and Dementia: A Systematic Review of Reviews. [PDF]

Am J Hypertens
Shajahan S, Heffernan M, Harris K, Carcel C, Woodward M, Anderson CS, Peters R.   +6 more
europepmc   +1 more source

Treating Hearing Loss With Hearing Aids for the Prevention of Cognitive Decline and Dementia. [PDF]

Neurology
Cribb L, Moreno-Betancur M, Pase MP, Wolfe R, Britt C, Zhou Z, Shah RC, Rance G, Sheets KM, Chong TT, Woods RL, Murray AM, Owen A, Ryan J.   +13 more
europepmc   +1 more source