Results 261 to 270 of about 965,316 (341)

Cortico‐Striatal‐Midbrain Circuit Dysregulation Underlying MK‐801 Induced Impulsivity and the Ameliorative Effects of SEP

Advanced Science, EarlyView.
Impulsivity is a symptom across multiple psychiatric disorders, yet its neural basis remains elusive. This study shows that the NMDAR antagonist MK‐801 elevates dopamine release and disrupts neuronal selectivity in the nucleus accumbens, leading to impulsive behavior.
Xueru Wang, Qinyu Li, Zijie Li, Xuejiao Wang, Hui Yuan, Pingting Yang, Ling Qin   +6 more
wiley   +1 more source

Cerebrovascular compromise and cognitive decline driven by chronic heart failure. [PDF]

Front Neurol
Zhao C, Du F, Hou X, Wu G, Cheng X, Cheng Q, Feng H, Zhu H, Wang M.   +8 more
europepmc   +1 more source

Temporal dynamic of cognitive decline in type 2 diabetes mellitus patients: a multimodal biomarker analysis using event-based modal and principal component analysis [PDF]

Min-Hua Ni, Bo Hu, Xiao-Yan Bai, Yao Tong, Zi-Yang Ma, Hao Xie, Xin-Yu Cao, Yan Yan Cui, Si Ning Li, Pan Dai, Li Juan Du, Xin Wen Yu, Lin-Feng Yan, Bin Gao, Ying Yu, Guang-Bin Cui   +15 more
openalex   +1 more source

Realgar‐Induced CNS Toxicity: Exploring OTC‐Mediated Ornithine Regulation of ZBTB7A Inhibits Astrocyte Glycolysis Based on the Liver–Brain Axis

Advanced Science, EarlyView.
Arsenic in realgar induces CNS toxicity through direct and indirect effects: it activates ZBTB7A in astrocytes, which in turn inhibits glycolysis and impairs mice's learning, memory, and exploration; it also suppresses OTC in the liver to block the ornithine cycle, leading to blood ornithine accumulation that crosses into the frontal lobe and further ...
Ping Ye, Zhen Li, Huanyong Fu, Shuai Wang, Xingang Cui, Chengbo Song, Chao Ma, Hong Jiang   +7 more
wiley   +1 more source

Integrating individualized connectome with amyloid pathology improves predictive modeling of future cognitive decline. [PDF]

Commun Med (Lond)
He H, Razlighi QR, Gazes Y, Habeck C, Stern Y, Alzheimer’s Disease Neuroimaging Initiative.   +5 more
europepmc   +1 more source

Physical exercise attenuates cognitive decline and reduces behavioural problems in people with mild cognitive impairment and dementia: a systematic review

, 2019
Chun-Kit Law, Freddy Man Hin Lam, Raymond C. K. Chung, Marco Y.C. Pang   +3 more
openalex   +1 more source

Dexamethasone and postoperative cognitive decline

European Journal of Anaesthesiology, 2018
Mark C, Kendall, Lucas J, Castro-Alves
openaire   +3 more sources

Potentiating Cerebral Perfusion Normalizes Glymphatic Dynamics in Systemic Inflammation

Advanced Science, EarlyView.
LPS‐induced systemic inflammation increases glymphatic influx but delays cervical lymphatic drainage, accompanied by AQP4 depolarization and impaired glymphatic clearance. Enhancing cerebral blood flow via the inotropic agent levosimendan effectively restored AQP4 polarization, improving glymphatic flux and amyloid‐β clearance.
Ruoyu Zhao, Bin Sun, Pengju Wei, Yingying Sun, Qianyan He, Kejia Zhang, Jun Lu, Shoujun Zhu, Yi Yang, Zhenni Guo   +9 more
wiley   +1 more source

Sleep, pericyte subtypes and cognitive decline in adults with and without Alzheimer's disease. [PDF]

Brain
Hamid M, Saha Detroja T, Tripathy SJ, Menon V, Xu J, Yu L, Wang Y, Buchman AS, Bennett DA, De Jager PL, Lim ASP.   +10 more
europepmc   +1 more source

CRISPRa Lipid Nanocomplex‐Mediated Mt3 Targeting Enhances Astrocytic Endocytosis of Amyloid‐β in an Alzheimer's Disease Mouse Model

Advanced Science, EarlyView.
GeTe exhibits intrinsically high carrier concentrations that limit its thermoelectric performance. Herein, CuAgSe alloying synergistically tunes the band structure, induces band flattening and valence‐band convergence, promotes Cu‐ion delocalization, and generates multiscale hierarchical structures to suppress phonon transport.
Junhang Park, Boyoung Kim, Minki Ha, Moonsu Park, Hongji Ryu, Hyerin Yu, Sungsoo Park, Yoon‐Seok Roh, Key‐Hwan Lim, Jin Tae Hong, Sang‐Bae Han, Chun‐Woong Park, Seok‐Beom Yong, Hanseul Park   +13 more
wiley   +1 more source