Results 61 to 70 of about 17,588,721 (291)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Argomentazioni Analogiche e Processi di Categorizzazione nella Diagnosi Nosologica

Rivista Internazionale di Filosofia e Psicologia, 2018
The purpose of this work is to provide a philosophical-cognitive explanation of nosological diagnosis by linking the classical philosophical themes of scientific reasoning (such as induction, deduction, abduction, analogy) to cognitive aspects of common ...
Francesco Gagliardi
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

A cognitive model of the positive symptoms of psychosis [PDF]

, 2001
In the last 10 years a consensus has developed that the symptoms of psychosis may be better understood by linking the steps between the phenomenological experiences and social, psychological and neurobiological levels of explanation.
Garety, PA, Freeman, D, Fowler, D, Kuipers, E, Freeman, D., Bebbington, PE, Bebbington, P. E., Freeman, Daniel, Fowler, D. G., Bebbington, P, Garety, P; id_orcid, Garety, P. A., Kuipers, E; id_orcid, Kuipers, E.   +13 more
core   +1 more source

Optimizing the teaching of electromagnetic wave polarization: A cognitive structure diagnostic approach

Acta Psychologica
Compared with traditional educational assessment methods, cognitive diagnosis theory pays more attention to the interpretability and guidance of assessment results, with the aim of better-guiding teaching and conducting personalized learning.
Xuefang Zhou, Qinjian Li, Miao Hu
doaj   +1 more source

Introducing the General Polytomous Diagnosis Modeling Framework

Frontiers in Psychology, 2018
Although considerable developments have been added to the cognitive diagnosis modeling literature recently, most have been conducted for dichotomous responses only.
Jinsong Chen, Jimmy de la Torre
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

The Impact of Sample Attrition on Longitudinal Learning Diagnosis: A Prolog

Frontiers in Psychology, 2020
Missing data are hard to avoid, or even inevitable, in longitudinal learning diagnosis and other longitudinal studies. Sample attrition is one of the most common missing patterns in practice, which refers to students dropping out before the end of the ...
Yanfang Pan, Peida Zhan
doaj   +1 more source

Development of a New Instrument for Depression With Cognitive Diagnosis Models [PDF]

Frontiers in Psychology, 2019
Most existing instruments for depression are developed based on classical test theory, factor analysis, or sometimes, item response theory, and focus on the accurate measurement of the severity of depressive disorder. Nevertheless, they tend to be less useful in supporting the decision based on ICD-10 or DSM-5 because of the lack of detailed ...
Daxun Wang, Xuliang Gao, Yan Cai, Dongbo Tu   +3 more
openaire   +3 more sources

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source