Results 31 to 40 of about 706,522 (143)

Role of neurovascular uncoupling in cognitive decline induced by metabolic disturbances: vascular explorations in a mice model

Cerebral Circulation - Cognition and Behavior
Introduction: A link between vascular risk factors caused by metabolic disorders in mid-life and the onset of cognitive impairments has been evidenced. Our team has demonstrated that, in a mice model, a cognitive decline occurred after 6 months of high ...
Manon Haas, Maud Pétrault, Thavarak Ouk, Patrick Gelé, Olivier Pétrault, Michèle Bastide   +5 more
doaj   +1 more source

Lateral hypothalamus orexinergic projection to the medial prefrontal cortex modulates chronic stress-induced anhedonia but not anxiety and despair

Translational Psychiatry
Chronic stress-induced anxiodepression is a common health problem, however its potential neurocircuitry mechanism remains unclear. We used behavioral, patch-clamp electrophysiology, chemogenetic, and optogenetic approaches to clarify the response of the ...
Danlei Liu, Xuefeng Zheng, Yuqing Hui, Yuanyuan Xu, Jinjiang Du, Zean Du, Yichen Che, Fengming Wu, Guangyin Yu, Jifeng Zhang, Xiaobing Gong, Guoqing Guo   +11 more
doaj   +1 more source

A case report of ruptured intracranial dissecting aneurysm associated with neurosyphilis

Interdisciplinary Neurosurgery
Intracranial dissecting aneurysm secondary to neurosyphilis is rare with only sporadic literature. Due to the insidious nature of the disease, as well as the rapid and dynamic changes of the intectious intracranial aneurysm, the outcome of treatment was ...
Ziwei Xu, Jie Chang, Jun Shu, Yiping Zhou, Aijuan Yan, Chunhui Gu, Lutian Bai, Wenshi Wei   +7 more
doaj   +1 more source

SARS-CoV-2 Nsp7 plays a role in cognitive dysfunction by impairing synaptic plasticity

Frontiers in Neuroscience
It has been reported that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can result in long-term neurological symptoms such as cognitive dysfunction, however the specific mechanisms underlying this phenomenon remain unclear ...
Jiazheng Guo, WeiLing Li, Mengbing Huang, Jialu Qiao, Pin Wan, Yulin Yao, Lirui Ye, Ye Ding, Jianing Wang, Qian Peng, Wei Liu, Yiyuan Xia, Xiji Shu, Binlian Sun, Binlian Sun   +14 more
doaj   +1 more source

Occupational therapy in special respite care: a new multicomponent model for challenging behavior in people with dementia

Geriatric Care, 2018
People with dementia experience a cognitive and functional decline and besides Behavioral and Psychological Symptoms (BPSD). BPSD represent the main cause of the dramatic deterioration in the quality of life and stress for patients and their families ...
Barbara Manni, Lucia Federzoni, Alessandro Lanzoni, Glenda Garzetta, Maud Graff, Andrea Fabbo   +5 more
doaj   +1 more source

How Therapeutic Tapping Can Alter Neural Correlates of Emotional Prosody Processing in Anxiety

Brain Sciences, 2019
Anxiety disorders are the most common psychological disorders worldwide resulting in a great demand of adequate and cost-effective treatment. New short-term interventions can be used as an effective adjunct or alternative to pharmaco- and psychotherapy ...
Nicola König, Sarah Steber, Josef Seebacher, Quinten von Prittwitz, Harald R. Bliem, Sonja Rossi   +5 more
doaj   +1 more source

Personality Disorder Cognitions in the Eating Disorders [PDF]

Journal of Nervous & Mental Disease, 2014
Patients with eating disorder have relatively high rates of comorbid personality disorder diagnoses, including both anxiety-based personality disorders (obsessive-compulsive and avoidant) and borderline personality disorder. However, there is preliminary evidence that the core cognitions underlying personality pathology in the eating disorders are ...
Gabriel, C., Waller, G.
openaire   +3 more sources

Fluorescent probes for sensing peroxynitrite: biological applications

Redox Report
Peroxynitrite (ONOO-) is a quintessential reactive oxygen species (ROS) and reactive nitrogen species (RNS), renowned for its potent oxidizing and nitrifying capabilities. Under normal physiological conditions, a baseline level of ONOO- is present within
Yan Yang, Jinting Shang, Yiyuan Xia, Yuran Gui   +3 more
doaj   +1 more source

Visceral adiposity links cerebrovascular dysfunction to cognitive impairment in middle-aged mice

Neurobiology of Disease, 2019
Midlife cognitive decline is now recognized as a factor of poor prognosis for late-life dementia. Although an epidemiological link has been suggested with high fat diet (HFD)-induced metabolic disorders, the effect of a long period of HFD on midlife ...
Olivier Pétrault, Maud Pétrault, Thavarak Ouk, Régis Bordet, Vincent Bérézowski, Michèle Bastide   +5 more
doaj   +1 more source

Collapsin Response Mediator Protein 2 and Endophilin2 Coordinate Regulation of AMPA Receptor GluA1 Subunit Recycling

Frontiers in Molecular Neuroscience, 2020
The dynamic trafficking of AMPA receptors (AMPARs), which enables the endocytosis, recycling, and exocytosis of AMPARs, is crucial for synaptic plasticity. Endophilin2, which directly interacts with the GluA1 subunit of AMPARs, plays an important role in
Jifeng Zhang, Jiong Li, Yichen Yin, Yichen Yin, Xueling Li, Yuxin Jiang, Yong Wang, Caihui Cha, Caihui Cha, Guoqing Guo   +9 more
doaj   +1 more source