NAP (davunetide) rescues neuronal dysfunction in a Drosophila model of tauopathy [PDF]
, 2013 Alzheimer’s disease (AD) is a devastating neurodegenerative disease causing irreversible cognitive decline in the elderly. There is no disease-modifying therapy for this condition and the mechanisms underpinning neuronal dysfunction and neurodegeneration
Cowan, C.M., Mudher, A., Quraishe, S.
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Pharmacological activation of the nuclear receptor REV-ERB reverses cognitive deficits and reduces amyloid-β burden in a mouse model of Alzheimer’s disease [PDF]
, 2019 Alzheimer’s disease currently lacks treatment options that effectively reverse the biological/anatomical pathology and cognitive deficits associated with the disease.
Burris, Thomas P +9 more
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Serum cystatin C levels are negatively correlated with post-stroke cognitive dysfunction
Neural Regeneration Research, 2020 Stroke is the leading cause of death and long-term disability worldwide, and cognitive impairment and dementia are major complications of ischemic stroke. Cystatin C (CysC) has been found to be a neuroprotective factor in animal studies.
Dao-Xia Guo +14 more
doaj +1 more source
Cognitive processess and cognitive reserve in multiple sclerosis [PDF]
, 2015 Multiple Sclerosis (MS) is characterized by motor, cognitive, and neuropsychiatric symptoms, which can occur independently. While MS is traditionally considered an inflammatory disease of the white matter, degeneration of gray matter is increasingly ...
Bruschetta, D. +9 more
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Sickle cell trait and risk of cognitive impairment in African-Americans: The REGARDS cohort [PDF]
, 2019 Background: Sickle cell anemia may be associated with cognitive dysfunction, and some complications of sickle cell anemia might affect those with sickle cell trait (SCT), so we hypothesized that SCT is a risk factor for cognitive impairment. Methods:
Cahill, Christina R. +12 more
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ToxicsDi-2-ethylhexyl phthalate (DEHP) is a widely used plasticizer with recognized sex-dependent neurotoxicity. However, research on adult neurotoxicity is scarce, especially in females.
Jing Bai +7 more
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Frontiers in Microbiology, 2022 The pathogenesis of Hepatic Encephalopathy (HE) is complex and multifactorial. The development of metagenomics sequencing technology led to show the significant role of gut microbiota in the pathogenesis of cognitive dysfunction, which paved the way for ...
Bowen Yang +5 more
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Salidroside alleviates ferroptosis of retinal ganglion cells in db/db mice
Food Science and Human WellnessSalidroside (Sal), is one of the important food supplements from the traditional Chinese medicine Integripetal rhodiola herb, encapsulating significant anti-oxidative stress, anti-ferroptosis, and neuroprotective attributes.
Wenqiang Liu +16 more
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Uniplanar nystagmus associated with perceptual and cognitive visual dysfunction due to presumed focal ischemic occipital cortical atrophy: a missed diagnosis and new observation [PDF]
, 2012 Uniplanar nystagmus has been described in relation to pathology of the brain stem, retina, optic nerve, sensory visual deprivation, periventricular leucomalacia, and drug toxicity.
Dorris, Liam +2 more
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source