Results 51 to 60 of about 892,444 (293)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Effects of Reminiscence Therapy Using Nostalgic SONGS on The Cognitive Function of The Elderly Living in The Community. [PDF]

, 2017
The study aimed to examine the effects of reminiscence therapy using nostalgic songs on the cognitive function of elderly people living in the community.
Hashimoto, Akiko, Jikumaru, Kiyoko, Okuda, Jun   +2 more
core  

Parkinson's disease dementia: a neural networks perspective. [PDF]

, 2015
In the long-term, with progression of the illness, Parkinson's disease dementia affects up to 90% of patients with Parkinson's disease. With increasing life expectancy in western countries, Parkinson's disease dementia is set to become even more ...
Foltynie, T, Gratwicke, J, Jahanshahi, M
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Comparison of prefrontal atrophy and episodic memory performance in dysexecutive Alzheimer’s disease and behavioural-variant frontotemporal dementia [PDF]

, 2016
Alzheimer’s disease (AD) sometimes presents with prominent executive dysfunction and associated prefrontal cortex atrophy. The impact of such executive deficits on episodic memory performance as well as their neural correlates in AD, however, remains ...
Alvarez, Ashburner, Bertoux, Bertoux, Binetti, Blennerhassett, Burgess, Chang, de Souza, Delis, Dickerson, Dunn, Fernandez-Calvo, Forman, Frisch, Gilbert, Gleichgerrcht, Gleichgerrcht, Godefroy, Good, Graham, Gregory, Hodges, Hornberger, Hornberger, Hornberger, Irish, Johnson, Kipps, Kopelman, Larner, Liu, Long, McKhann, Meyers, Mez, Mioshi, Mioshi, Moayedi, Morris, Nestor, Nichols, Ossenkoppele, Pa, Pennington, Possin, Rascovsky, Reitan, Rueckert, Savage, Schmidt, Seeley, Smith, Somerville, Swanberg, Torralva, Wedderburn, Wong, Woodward, Woodward, Woodward, Woodward, Zhang, Zheng   +63 more
core   +1 more source

Cognitive dysfunction in mania

Comprehensive Psychiatry, 1986
Abstract We tested 30 manics and 42 normal controls on a battery of neuropsychological tasks selected to assess regional cortical functioning in both cerebral hemispheres. Nearly half the manics exhibited moderate or severe global cognitive impairment, whereas no control showed more than a mild performance deficit.
M A, Taylor, R, Abrams
openaire   +2 more sources

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Astrocytic GSTM2-STAT3 interaction ameliorates the diabetes associated cognitive dysfunction via targeting mitochondrial defects and oxidative stress

Redox Biology
Diabetes associated cognitive dysfunction (DACD) present a substantial challenge to the management of diabetic patient. The pathogenesis of DACD is intricately associated with mitochondrial defects and oxidative stress.
Wenqiang Liu, Yufei Wang, Yunshuang Zhao, Bingxue Song, Linqin Luo, Khan Muhammad Zahir, Miaomiao Song, Yong Wang, Li Zhang, Zhongfu Zuo, Lu Yao   +10 more
doaj   +1 more source

Association between levels of trimethylamine N-oxide and cognitive dysfunction: a systematic review and meta-analysis [PDF]

PeerJ
Background Previous studies have shown that the differential expression of trimethylamine N-oxide (TMAO) is closely related to the prognosis of cognitive dysfunction, but the conclusion is still controversial.
Zhendong Ren, LuMeng Mo
doaj   +2 more sources

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source