Results 61 to 70 of about 2,903,135 (304)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Salidroside protects RGC from pyroptosis in diabetes-induced retinopathy associated with NLRP3, NFEZL2 and NGKB1, revealed by network pharmacology analysis and experimental validation

European Journal of Medical Research
Objective To investigate the effect of salidroside (SAL) in protecting retinal ganglion cell (RGC) from pyroptosis and explore associated molecular network mechanism in diabetic retinapathy (DR) rats.
Lan-Chun Zhang, Na Li, Min Xu, Ji-Lin Chen, Hua He, Jia Liu, Ting-Hua Wang, Zhong-Fu Zuo   +7 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Evaluation of Cognitive Dysfunction, Functional Independence and Depression Severity Changes during Rehabilitation in Patients after Cerebral Stroke

Reabilitacijos Mokslai: Slauga, Kineziterapija, Ergoterapija, 2019
Research background. Cognitive impairment and depression are frequent residual consequences of stroke. They have a large impact on the quality of life and long-term prognosis.
Gintarė Mankė, Lina Varžaitytė, Aistė Berkutė, Erika Karkauskienė   +3 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

The Association between Daytime Napping and Cognitive Functioning in Chronic Fatigue Syndrome [PDF]

, 2015
OBJECTIVES The precise relationship between sleep and physical and mental functioning in chronic fatigue syndrome (CFS) has not been examined directly, nor has the impact of daytime napping.
Zoe M Gotts, Vincent Deary, Nicola Barclay, Jason G Ellis, Ellis, Jason, Deary, Vincent, Barclay, Nicola, Newton, Julia, Julia L Newton, Gotts, Zoe   +9 more
core   +2 more sources

Posterior Cortical Atrophy in the Asia‐Pacific: A Report From the PCA Asian Workgroup

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Posterior Cortical Atrophy (PCA) is a distinct dementia syndrome primarily affecting spatial abilities and visual processing. It is associated with degeneration in the posterior part of the brain. PCA is subclassified into PCA‐pure and PCA‐plus syndromes based on consensus criteria.
Yuttachai Likitjaroen, Ya‐Ting Chang, Levinia Lim, Pai‐Yi Chiu, Jung‐Lung Hsu, SangYun Kim, Wataru Narita, Na Young Ryoo, Kyoko Suzuki, Nagaendran Kandiah, Sebastian Crutch, Ming‐Chyi Pai   +11 more
wiley   +1 more source

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source

Obesity and cognitive dysfunction

Ожирение и метаболизм, 2016
Obesity takes epidemic proportions, encompassing different groups of society. In turn, cerebrovascular pathology holds a leading position in the spectrum of neurological disorders.
Mariia Vladimirovna Matveeva, Julia Gennadevna Samoylova, Natalija Grigorevna Zhukova   +2 more
doaj   +1 more source

Cognitive dysfunction after isolated brain stem insult. An underdiagnosed cause of long term morbidity [PDF]

, 2002
Cognitive dysfunction adversely influences long term outcome after cerebral insult, but the potential for brain stem lesions to produce cognitive as well as physical impairments is not widely recognised.
Losseff, N., Jager, H., Playford, D, Losseff, N, P Garrard, Garrard, P., Garrard, P, Bradshaw, D, Jäger, HR, Thompson, A.J., Bradshaw, D., Playford, D., Thompson, AJ, Jager, H.R., Playford, E. Diane, Thompson, A.   +15 more
core   +1 more source