Results 71 to 80 of about 2,903,135 (304)

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Recognition of cognitive dysfunction in hospitalised older patients: a flash mob study

BMC Geriatrics
Background It is important that healthcare professionals recognise cognitive dysfunction in hospitalised older patients in order to address associated care needs, such as enhanced involvement of relatives and extra cognitive and functional support ...
Fleur C. W. Visser, Marlise E. A. van Eersel, Liesbeth Hempenius, Nicolaas A. Verwey, Caterina Band, Jessica M. van der Bol, Kris Boudestein, Suzanne C. van Dijk, Robbert Gobbens, Cornelis S. van der Hooft, Adriaan M. Kamper, Rikje Ruiter, Walther Sipers, Birgit N. A. Spoelstra, Josephine Stoffels, Dyane J. Stolwijk-Woudstra, Karlijn J. van Stralen, Astrid M. van Strien, Marjolein A. Wijngaarden, Marian Winters, Fijanne Strijkert, Barbara C. van Munster   +21 more
doaj   +1 more source

Concomitant diastolic dysfunction further interferes with cognitive performance in moderate to severe systolic heart failure. [PDF]

PLoS ONE, 2017
Studies of the relevance of cardiac functional markers to cognitive performance in heart failure (HF) have primarily focused on systolic markers. In this study, we examine whether concomitant diastolic dysfunction further interferes with cognitive ...
Mi-Seung Shin, Minjeong An, Sunhwa Kim, Jae Lan Shim, Jin-Kyu Park, JinShil Kim   +5 more
doaj   +1 more source

Proposing a new focus for the study of natural and artificial cognitive systems [PDF]

, 2002
In the study of systems the function of the system is often a good hint to how it works. In the following paper I would like to suggest that in studying or modeling a cognitive system our pre-knowledge of their functions should be treated carefully.
Hershberg, Uri
core  

The role of objective cognitive dysfunction in subjective cognitive complaints after stroke

, 2017
Background and purpose: Objective cognitive performance (OCP) is often impaired in patients post-stroke but the consequences of OCP for patient-reported subjective cognitive complaints (SCC) are poorly understood.
M. M. Sitskoorn, W. J. Kop, Mark, R E; id_orcid, Mark, R E, Kop, W J, de Kort, P L M, P. L. M. de Kort, M. W. A. van Rijsbergen, R. E. Mark, Rijsbergen, M.W.A., Sitskoorn, M M   +10 more
core   +1 more source

Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone, Freddy Chafota, Miguel E. Rentería, Randi J. Hagerman, Ellery Santos, Anna Atkinson, Nicholas G. Martin, Elsdon Storey, Danuta Z. Loesch   +8 more
wiley   +1 more source

Postoperative delirium and cognitive dysfunction [PDF]

British Journal of Anaesthesia, 2009
Postoperative delirium and cognitive dysfunction (POCD) are topics of special importance in the geriatric surgical population. They are separate entities, whose relationship has yet to be fully elucidated. Although not limited to geriatric patients, the incidence and impact of both are more profound in geriatric patients.
S, Deiner, J H, Silverstein
openaire   +2 more sources

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source

Longitudinal Assessment of Biomarkers in ALS: Discriminative Biomarkers for Disease Progression and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the association and discriminative performance of serum biomarkers with clinical disease progression and survival in patients with amyotrophic lateral sclerosis (ALS). Methods This retrospective study, conducted at Houston Methodist Hospital, Houston, TX, used longitudinal serum samples collected between January 2018 and ...
David R. Beers, Yueh‐Yun Lin, Jason R. Thonhoff, Aaron D. Thome, Alireza Faridar, Weihua Zhao, Shixiang Wen, Stanley H. Appel   +7 more
wiley   +1 more source

Cognitive-Behavioral Erectile Dysfunction Treatment for Gay Men

   The purpose of the present paper is to assist cognitive-behavioral therapists who are treating erectile dysfunction among gay men. Little information is available to cognitive-behavioral therapists about the psychological and social effects of ...
Danielle R. Schwartz (10849863), Trevor Hart (18106417)   +1 more
core   +1 more source