Results 41 to 50 of about 2,903,135 (304)

Cognitive dysfunction in patients with cerebral microbleeds on T2*-weighted gradient-echo MRI.

, 2004
Gradient echo T2*-weighted MRI has high sensitivity in detecting cerebral microbleeds, which appear as small dot-like hypointense lesions. Microbleeds are strongly associated with intracerebral haemorrhage, hypertension, lacunar stroke and ischaemic ...
Werring, David J, WATT H, BROWN MM, Cipolotti, Lisa, COWARD LJ, JAGER HR, Brown, Martin M, Jäger, H Rolf, FRAZER DW, Coward, Lucy J, WERRING DJ, Watt, Hilary, LOSSEFF NA, Frazer, Duncan W, Losseff, Nick A   +14 more
core   +1 more source

Neuropsychological and Educational Outcomes in Shwachman–Diamond Syndrome—A Report From the North American Shwachman–Diamond Syndrome Registry

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Shwachman–Diamond syndrome (SDS) is a rare autosomal recessive ribosomopathy characterized by bone marrow failure and multisystem involvement, with emerging evidence of associated neurocognitive impairment. Methods We conducted a retrospective study of 240 individuals with biallelic Shwachman–Bodian–Diamond syndrome (SBDS) mutations
Jane Koo, Melissa Gerstle, Leah Cheng, Richard Cooper, Katherine Coyne, Claire Dusa, Naomi E. Joffe, Diana Schwarz, Sarah Steltz, Akiko Shimamura, Kasiani C. Myers, Thea Quinton   +11 more
wiley   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Evaluating the association between diabetes, cognitive decline and dementia [PDF]

, 2015
The aim of this article is to review the association between diabetes mellitus, cognitive decline and dementia, including the effects of cognitive decline and dementia on self management of diabetes.
Brooke, Joanne, Omorogieva Ojo, Joanne Brooke, Ojo, Omorogieva   +3 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

A study to evaluate the relationship between diabetes mellitus and cognitive dysfunction

Asian Journal of Medical Sciences, 2022
Background: Diabetes mellitus (DM) is the most common endocrine disorder. It leads to slow progressive end-organ damage (both microvascular and macrovascular). The cognitive dysfunction is a less known and less addressed complication of DM.
Rakesh Kumar Patel , Karan Saran Kapur , Sardar Eske   +2 more
doaj   +1 more source

signaling in cognitive aging and cerebrovascular dysfunction of Alzheimer's disease

, 2020
Age-related cognitive failure is a main devastating incident affecting even healthy people. Alzheimer's disease (AD) is the utmost common form of dementia among the geriatric community.
Asma Perveen, Behl, Tapan, Barreto, George E, Mathew, Bijo, George E. Barreto, Ashraf, Ghulam Md, Rahman, Md Ataur, Tapan Behl, Bijo Mathew, May N. Bin‐Jumah, Kabir, Md Tanvir, Bin-Jumah, May N, Mohamed M. Abdel‐Daim, Ghulam Md Ashraf, Md. Ataur Rahman, Md. Sahab Uddin, Perveen, Asma, Md. Tanvir Kabir, Uddin, Md Sahab, Abdel-Daim, Mohamed M   +19 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Dysfunction of EAAT3 Aggravates LPS-Induced Post-Operative Cognitive Dysfunction

Membranes, 2022
Numerous results have revealed an association between inhibited function of excitatory amino acid transporter 3 (EAAT3) and several neurodegenerative diseases.
Xiao-Yan Wang, Wen-Gang Liu, Ai-Sheng Hou, Yu-Xiang Song, Yu-Long Ma, Xiao-Dong Wu, Jiang-Bei Cao, Wei-Dong Mi   +7 more
doaj   +1 more source