Results 71 to 80 of about 339,240 (318)
Progressive Myoclonus Epilepsy: Distinctive MRI Changes in Cerebellar and Motor Networks
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Progressive myoclonus epilepsy (PME) is a rare generalized epilepsy syndrome with a well‐characterized genetic basis. The brain networks that are affected to give rise to the distinctive symptoms of PME are less well understood. Methods Eleven individuals with PME with a confirmed genetic diagnosis and 22 controls were studied.
Jillian M. Cameron +3 more
wiley +1 more source
A hierarchical narrative framework for OCD [PDF]
arXiv, 2015 This paper gives an explanatory framework for obsessive-compulsive disorder (OCD) based on a generative model of cognition. The framework is constructed using the new concept of a 'formal narrative' which is a sequence of cognitive states inferred from sense data.
arxiv
Disentangling brain heterogeneity via semi-supervised deep-learning and MRI: dimensional representations of Alzheimer's Disease [PDF]
arXiv, 2021 Heterogeneity of brain diseases is a challenge for precision diagnosis/prognosis. We describe and validate Smile-GAN (SeMI-supervised cLustEring-Generative Adversarial Network), a novel semi-supervised deep-clustering method, which dissects neuroanatomical heterogeneity, enabling identification of disease subtypes via their imaging signatures relative ...
arxiv
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Certain frontotemporal lobar degeneration subtypes, including TDP‐A and B, can either occur sporadically or in association with specific genetic mutations. It is uncertain whether syndromic or imaging features previously associated with these patient groups are subtype or genotype specific.
Sean Coulborn +17 more
wiley +1 more source
Null Dynamical State Models of Human Cognitive Dysfunction [PDF]
arXiv, 2017 The hard problem in artificial intelligence asks how the shuffling of syntactical symbols in a program can lead to systems which experience semantics and qualia. We address this question in three stages. First, we introduce a new class of human semantic symbols which appears when unexpected and drastic environmental change causes humans to become ...
arxiv
Cognitive Reserve and the Risk of Postoperative Cognitive Dysfunction [PDF]
Deutsches Ärzteblatt international, 2017 Post-operative cognitive dysfunction (POCD) occurs in 10 to 54% of older patients during the first few weeks after surgery, but little is known about risk factors predisposing to POCD.Systematic literature review and meta-analysis of cognitive reserve indicators and POCD risk.Fifteen studies on 5104 patients were included.
Tobias Pischon +3 more
openaire +3 more sources
Early BMI Change, Cognitive Decline, and CSF AD Biomarkers Alterations in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To examine the relationship of early BMI change with subsequent cognitive decline, CSF AD biomarkers alterations, and progression to dementia in patients with PD. Methods Study data were prospectively collected from the PPMI cohort. Weight/height data at enrollment and second‐year clinical visit were utilized to calculate BMI change.
Rui Zhong, Kezhong Zhang
wiley +1 more source
How do eyes and brain search a randomly structured uninformative scene? Exploiting a basic interplay of attention and memory [PDF]
Eye Movement: Developmental Perspectives, Dysfunctions and
Disorders in Humans, Ed. L. C. Stewart, Chapter 1, pp. 1-48, 2013. NOVA
Science Publisher, Inc., ISBN: 978-1-62808-601-0, 2020 We tracked the eye movements of seven young and seven older adults performing a conjunctive visual search task similar to that performed by two highly trained monkeys in an original influential study of Motter and Belky (1998a, 1998b). We obtained results consistent with theirs regarding elements of perception, selection, attention and object ...
arxiv
Claustrum Volume Is Reduced in Multiple Sclerosis and Predicts Disability
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective The claustrum is a small, thin structure of predominantly gray matter with broad connectivity and enigmatic function. Little is known regarding the impact of claustrum pathology in multiple sclerosis (MS). Methods This study assessed whether claustrum volume was reduced in MS and whether reductions were associated with specific ...
Nicole Shelley +5 more
wiley +1 more source
Critical appraisal on mitochondrial dysfunction in Alzheimer’s disease
AGING MEDICINE, Volume 5, Issue 4, Page 272-280, December 2022., 2022 Amyloid plaques deposit on neurons in case of Alzheimer's Disease. Mitochondria play a vital role in pathogenesis of Alzheimer's Disease. Mitochondrial dysfunction can lead to formation of mPTP, alteration of complexes 1,3 and 4, deficits in bioenergetics with impaired mitochondrial biogenesis. Abstract It is widely recognized that Alzheimer's disease (
Faizan Ahmad, Punya Sachdeva
wiley +1 more source