Results 131 to 140 of about 478,390 (292)

La fatigue cognitive : parfois méconnue, toujours handicapante

, 2017
Des centaines de milliers de Français souffrent de fatigue cognitive, un sérieux handicap dans leur vie de tous les jours.
openaire   +2 more sources

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

Advanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu, Yunmin Zhu, Xi Wang, Zelin Wu, Zijian Xu, Rongqing Chen, Yanwu Guo   +6 more
wiley   +1 more source

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

Impact of Temporal Window Shift on EEG-Based Machine Learning Models for Cognitive Fatigue Detection

Algorithms
In our study, we examine how the temporal window shift—the step between consecutive analysis windows—affects EEG-based cognitive fatigue detection while keeping the window length fixed.
Agnieszka Wosiak, Michał Sumiński, Katarzyna Żykwińska   +2 more
doaj   +1 more source

Evaluating the effects of brain injury, disease and tasks on cognitive fatigue. [PDF]

Sci Rep, 2023
Wylie GR, Genova HM, Yao B, Chiaravalloti N, Román CAF, Sandroff BM, DeLuca J.   +6 more
europepmc   +1 more source

Repugnance as Performance Error: The Role of Disgust in Bioethical Intuitions [PDF]

, 2016
An influential argument in bioethics involves appeal to disgust, calling on us to take it seriously as a moral guide (e.g. Kass, Miller, Kahan). Some argue, for example, that genetic enhancement, especially via human reproductive cloning, is repellant or
May, Joshua
core  

Cognitive aspects of chronic fatigue syndrome [PDF]

, 1997
Recent interest in cognitive behavioural therapy techniques for treatment of Chronic Fatigue Syndrome (CFS) has highlighted the contribution of psychological approaches to alleviating the debilitating symptoms of this illness. In previous research sufferers from CFS have been compared with depressed patients and patients with neuromuscular disease, as ...
openaire   +1 more source

FOCUS: A Four‐In‐One Consolidated Unison Strain Sensor with Enhanced Sensitivity

Advanced Science, EarlyView.
Through a folding transformation that stacks four printed liquid metal sensors into a unified 3D orthogonal construct, FOCUS harnesses complementary bidirectional resistance responses within a Wheatstone bridge. This architecture yields fivefold sensitivity enhancement and 25 µm resolution, overcoming LM sensors’ micro‐strain limitations and enabling ...
Zimeng Wang, Ruiran Li, Bowen Yang, Zhuofei Peng, Muyang Jing, Yu Gu, Lixue Tang   +6 more
wiley   +1 more source

The effects of mental fatigue and caffeine on basketball performance: insights from a crossover study

Journal of the International Society of Sports Nutrition
Background The interactive effect of mental fatigue and caffeine consumption on sport performance is not clear. This study aimed to investigate the impact of mental fatigue and caffeine gum consumption on power and skill performance in recreationally ...
Mehdi Hemmat, Gholamhosein Nazemzadegan, Alireza Niknam, Farhad Daryanoosh, Maryam Koushkie Jahromi   +4 more
doaj   +1 more source

Gut Microbiota‐Non‐Coding RNA Axis in Immune Modulation and Disease: From Mechanisms to Clinical Translation

Advanced Science, EarlyView.
ABSTRACT Immune homeostasis is indispensable for preserving organismal integrity, orchestrated through complex molecular networks encompassing immune cell dynamics, microbial cues, and epigenetic regulation. Among these, the gut microbiota‐non‐coding RNA (ncRNA) axis has recently garnered substantial attention as a multifaceted modulator of host ...
Bonan Chen, Guoming Chen, Xieyuan Leng, Qianfan Li, Wenhao Wu, Wenqiu Wu, Zixuan Liu, Zilan Zhong, Xiaohong Zheng, Wei Kang, Fazheng Ren, Yigan Zhang, Juan Chen   +12 more
wiley   +1 more source