Results 191 to 200 of about 1,931,867 (302)

Bidirectional Pathological Axis Between Alzheimer's Disease and Circadian Rhythm Disturbance: Mechanisms and Therapeutic Strategies

open access: yesiNew Medicine, EarlyView.
This graphical abstract illustrates a bidirectional vicious cycle between Alzheimer’s disease (AD) and circadian rhythm disturbance (CRD). On the one hand, AD pathology, including amyloid‐β (Aβ) plaque deposition and tau hyperphosphorylation, may damage the suprachiasmatic nucleus (SCN) and disrupt melatonin signaling, leading to sleep fragmentation ...
Jiajia Qin   +10 more
wiley   +1 more source

A nomogram model for identifying cognitive frailty in elderly patients with chronic diseases: a multicenter cross-sectional study. [PDF]

open access: yesFront Public Health
Huang S   +11 more
europepmc   +1 more source

Deliberate Practice Supervision to Enhance the Effectiveness of Behavioral Activation for Depression: A Case Study

open access: yesJournal of Clinical Psychology, Volume 81, Issue 6, Page 526-537, June 2025.
ABSTRACT Deliberate Practice (DP) is a model of behavioral skill acquisition structured by several key tasks. The past decade has shown a consistent growth in interest in this form of learning for psychotherapy skills, with promising research suggesting DP training is superior to traditional learning methods of psychotherapy. This paper presents a case
Dan Sacks
wiley   +1 more source

Harnessing personal and social resources in managing internalising and externalising symptoms in children living in low‐resource settings

open access: yesJCPP Advances, EarlyView.
Abstract Background Children growing up in low‐resource settings are at greater risk for lifelong psychiatric problems. They are both more likely to have risk factors for early psychopathology and to be less likely to seek help and engage support for these problems.
Julia E. Michalek   +4 more
wiley   +1 more source

Transdiagnostic profiles of socio‐affective functioning in adolescents at‐risk of poor mental health

open access: yesJCPP Advances, EarlyView.
Abstract Background Adolescence is a developmental period during which many mental health problems emerge or worsen. Recently, there has been a shift towards identifying risk factors that predict psychopathology across a range of diagnostic boundaries—known as ‘transdiagnostic’ approaches.
Alex Lloyd   +7 more
wiley   +1 more source

Association Between Deep Gray Matter Iron Deposition Dysregulation and Cognitive Performance in Type 2 Diabetes Mellitus Patients: A Quantitative Susceptibility Mapping Study

open access: yesJournal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Type 2 diabetes (T2DM) heightens cognitive impairment risk, yet the mechanisms remain unclear. Hyperglycemia‐induced iron dysregulation in deep gray matter (DGM) nuclei may be a crucial mechanism. Purpose To investigate DGM iron deposition in T2DM using Quantitative Susceptibility Mapping (QSM) and determine its association with ...
Kun Wang   +5 more
wiley   +1 more source

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