Results 71 to 80 of about 2,478,389 (308)

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Force Steadiness During a Cognitively Challenging Motor Task Is Predicted by Executive Function in Older Adults [PDF]

, 2018
Motor performance and cognitive function both decline with aging. Older adults for example are usually less steady for a constant-force task than young adults when performing low-intensity contractions with limb muscles.
Hunter, Sandra K., Nielson, Kristy A., Pereira, Hugo M., Schlinder-Delap, Bonnie A., Mrs.   +3 more
core   +1 more source

Gamma power in rural Pakistani children: links to executive function and verbal ability [PDF]

, 2017
Children in low- and middle-income countries are at high risk of cognitive deficits due to environmental deprivation that compromises brain development.
Keehn, Brandon, Nelson, Charles A., Obradovic, Jelena, Rasheed, Muneera A., Siyal, Saima, Tarullo, Amanda R., Yousafzai, Aisha K.   +6 more
core   +2 more sources

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Histamine H3 receptor inverse agonists/antagonists influence intra-regional cortical activity and inter-regional synchronization during resting state: an exploratory cortex-wide imaging study in mice

Molecular Brain
The histaminergic system plays a key role in modulating learning and memory, wakefulness, and energy balance. Histamine H3 receptors constitutively inhibit the synthesis and release of histamine and other neurotransmitters. Therefore, H3 receptor inverse
Sentaro Kaita, Yoshikazu Morishita, Kenta Kobayashi, Hiroshi Nomura   +3 more
doaj   +1 more source

A Deflationary Account of Mental Representation [PDF]

, 2020
Among the cognitive capacities of evolved creatures is the capacity to represent. Theories in cognitive neuroscience typically explain our manifest representational capacities by positing internal representations, but there is little agreement about how
Egan, Frances
core  

The Nature and Function of Content in Computational Models [PDF]

, 2018
Much of computational cognitive science construes human cognitive capacities as representational capacities, or as involving representation in some way.
Egan, Frances
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

A novel micro-ECoG recording method for recording multisensory neural activity from the parietal to temporal cortices in mice

Molecular Brain, 2023
Characterization of inter-regional interactions in brain is essential for understanding the mechanism relevant to normal brain function and neurological disease.
Susumu Setogawa, Ryota Kanda, Shuto Tada, Takuya Hikima, Yoshito Saitoh, Mikiko Ishikawa, Satoshi Nakada, Fumiko Seki, Keigo Hikishima, Hideyuki Matsumoto, Kenji Mizuseki, Osamu Fukayama, Makoto Osanai, Hiroto Sekiguchi, Noriaki Ohkawa   +14 more
doaj   +1 more source

A Pilot Study: The Beneficial Effects of Combined Statin-exercise Therapy on Cognitive Function in Patients with Coronary Artery Disease and Mild Cognitive Decline. [PDF]

, 2017
Objective Hypercholesterolemia, a risk factor in cognitive impairment, can be treated with statins. However, cognitive decline associated with "statins" (HMG-CoA reductase inhibitors) is a clinical concern.
Hamada, Mari, Horio, Eiji, Iwasaki, Yuri, Nakamura, Shinichi, Ogawa, Hisao, Oka, Hideki, Rokutanda, Taku, Spin, Joshua M, Sugiyama, Seigo, Toyama, Kensuke, Tsao, Philip S   +10 more
core   +1 more source