Results 71 to 80 of about 2,466,460 (289)

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Visual Acuity does not Moderate Effect Sizes of Higher-Level Cognitive Tasks. [PDF]

, 2016
Background/study contextDeclining visual capacities in older adults have been posited as a driving force behind adult age differences in higher-order cognitive functions (e.g., the "common cause" hypothesis of Lindenberger & Baltes, 1994, Psychology ...
Allen, Philip A, Bennett, Ilana J, Houston, James R, Madden, David J   +3 more
core   +2 more sources

Enhancing Oncological Care for India's Aging Population: Addressing the Complex Needs of Older Adults With Cancer

Aging and Cancer, EarlyView.
Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath, Mathigatta Shivarudraiah S, Rajath Govind, Kaushik M R   +3 more
wiley   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Histamine H3 receptor inverse agonists/antagonists influence intra-regional cortical activity and inter-regional synchronization during resting state: an exploratory cortex-wide imaging study in mice

Molecular Brain
The histaminergic system plays a key role in modulating learning and memory, wakefulness, and energy balance. Histamine H3 receptors constitutively inhibit the synthesis and release of histamine and other neurotransmitters. Therefore, H3 receptor inverse
Sentaro Kaita, Yoshikazu Morishita, Kenta Kobayashi, Hiroshi Nomura   +3 more
doaj   +1 more source

Gamma power in rural Pakistani children: links to executive function and verbal ability [PDF]

, 2017
Children in low- and middle-income countries are at high risk of cognitive deficits due to environmental deprivation that compromises brain development.
Keehn, Brandon, Nelson, Charles A., Obradovic, Jelena, Rasheed, Muneera A., Siyal, Saima, Tarullo, Amanda R., Yousafzai, Aisha K.   +6 more
core   +2 more sources

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

A novel micro-ECoG recording method for recording multisensory neural activity from the parietal to temporal cortices in mice

Molecular Brain, 2023
Characterization of inter-regional interactions in brain is essential for understanding the mechanism relevant to normal brain function and neurological disease.
Susumu Setogawa, Ryota Kanda, Shuto Tada, Takuya Hikima, Yoshito Saitoh, Mikiko Ishikawa, Satoshi Nakada, Fumiko Seki, Keigo Hikishima, Hideyuki Matsumoto, Kenji Mizuseki, Osamu Fukayama, Makoto Osanai, Hiroto Sekiguchi, Noriaki Ohkawa   +14 more
doaj   +1 more source

A Deflationary Account of Mental Representation [PDF]

, 2020
Among the cognitive capacities of evolved creatures is the capacity to represent. Theories in cognitive neuroscience typically explain our manifest representational capacities by positing internal representations, but there is little agreement about how
Egan, Frances
core  

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source