Results 231 to 240 of about 120,012 (270)

Photo‐Biomodulation of the Hippocampus Using Near‐Infrared Laser to Enhance Cognitive Function in Mice

Advanced Science, EarlyView.
Here a transcranial photo‐biomodulation approach is developed using near‐infrared (NIR) laser on hippocampus of mice, revealing significant improvements in learning and memory ability of mice under normal and disease conditions. The improvement results from the high‐density cell‐induced NIR local energy deposition, neuronal activation, and axonogenesis
Wei‐Tong Pan, Han‐Wen Gu, Yan‐Bo Zhou, Sophie Ma, Daqing Ma, Pan‐Miao Liu, Jian‐Jun Yang   +6 more
wiley   +1 more source

Endothelial PD‐1 Regulates Vascular Homeostasis and Oligodendrogenesis during Brain Development

Advanced Science, EarlyView.
Vascular endothelial cells are fundamental for angiogenesis and brain development. This study reveals that endothelial programmed cell death 1 (PD‐1) is critical for cerebral angiogenesis and blood brain barrier (BBB) maturation. It also mediates interaction with oligodendrocyte precursor cells (OPCs), modulating OPCs differentiation and myelination ...
Tingting He, Mengtian Zhang, Jie Qin, Yanyan Wang, Sihan Li, Chaoyi Du, Jianwei Jiao, Fen Ji   +7 more
wiley   +1 more source

Agile Free‐Form Signal Filtering and Routing with a Chaotic‐Cavity‐Backed Non‐Local Programmable Metasurface

Advanced Science, EarlyView.
A multi‐parameter‐tunable, all‐metallic, low‐loss, wave‐chaotic cavity enables a frequency‐insensitive (over a 7 GHz bandwidth) technique to synthesize desired transfer functions within smaller windows to high accuracy and with complete reconfigurability of shapes and center frequencies.
Fabian T. Faul, Laurent Cronier, Ali Alhulaymi, A. Douglas Stone, Philipp del Hougne   +4 more
wiley   +1 more source

Piezoresistive Effect: A New Concept for Hearing Aids

Advanced Science, EarlyView.
An MXene/PVA sound sensor utilizing piezoresistive effects has been proposed with a detection limit of 60 dB and a frequency response of 20–4000 Hz, which is comparable to the performance of commercial hearing aids. By combining the sensor with machine learning, the accuracy rate of voiceprint recognition of wildlife conservation can reach up to 99 ...
Mengyao Gao, Weijie Liu, Kun Chen, Huili Sun, Xiaoqing Liu, Haonan Xing, Huatang Wang, Benpeng Zhu, Haizhong Guo   +8 more
wiley   +1 more source

IFITM2 Modulates Endocytosis Maintaining Neural Stem Cells in Developing Neocortex

Advanced Science, EarlyView.
This study reveals IFITM2 as a key regulator of endocytosis in radial glial cells (RGCs) during brain development. IFITM2's YXXø motif and phosphoinositide‐binding residues (K82/K87) are essential for endosome formation. IFITM2 deficiency disrupts the embryonic cortical neurogenesis, revealing a conserved mechanism linking endocytic dynamics to neural ...
Yuqing Lv, Wenzheng Zou, Lin Li, Shukui Zhang, Jiaqi Liang, Jiali Pu, Jianwei Jiao   +6 more
wiley   +1 more source

Rational Design and Organoid‐Based Evaluation of a Cocktail CAR‐γδ T Cell Therapy for Heterogeneous Glioblastoma

Advanced Science, EarlyView.
A novel “prof” cocktail therapy is designed. It screens antigens, selects personalized antigen panels, engineers optimized CAR‐Vδ1 T cells, and tests in patient‐derived GBM organoids, offering hope for effective CAR‐T drugs against heterogeneous solid tumors. Abstract Various challenges, including tumor heterogeneity and inadequate T cell infiltration,
Guidong Zhu, Zhongzheng Sun, Yingchao Liu, Jiang Liu, Linpei Guo, Guojing Pei, Ying Jiang, Baowang Miao, Zhen Li, Ping Zhang, Dongqi Tang, Wen Zhang, Chengwei Wang   +12 more
wiley   +1 more source

Editorial: Effects of vascular function and aging on brain circulation and neurodegeneration

Frontiers in Aging
Benjamin Petersen, Benjamin Petersen, Sharon Negri, Sharon Negri, Madison Milan, Madison Milan, Helen Shi, Helen Shi, Zeke Reyff, Zeke Reyff, Cade Ballard, Cade Ballard, Jennifer Ihuoma, Jennifer Ihuoma, Andrea Di Francesco, Stefano Tarantini, Stefano Tarantini, Stefano Tarantini, Stefano Tarantini, Stefano Tarantini   +19 more
doaj   +1 more source

The Locus Coeruleus‐Periaqueductal Gray GABAergic Projection Regulates Comorbid Pain and Depression

Advanced Science, EarlyView.
LC‐GABA neurons exhibit elevated activity to noxious and aversive stimuli in chronic pain, and their activation alleviates pain‐ and depression‐like behaviors. While LC‐GABA neurons target LC‐NA neurons and GABA and Glu neurons in the vlPAG, they modulate the pain responses of LC‐NA neurons but regulate pain‐ and depression‐like behaviors through their
Yuan Gao, Xue Zhang, Xiao‐Juan Liu, Yi‐Ling Sun, Cui Yin, Dong‐Liang Tang, Cheng Xiao, Chunyi Zhou   +7 more
wiley   +1 more source

Ferroelectric‐Assisted Ion Dynamics for Prolonged Tactile Cognizance in a Biomimetic Memory‐in‐Sensor System

Advanced Electronic Materials, EarlyView.
A promising mechanoreceptor‐inspired tactile memory‐in‐sensor (TMIS) device is reported, utilizing ferroelectric‐assisted ion dynamics in a synaptic tactile transistor (FAID‐STT). This design enhances long‐term tactile memory while minimizing power consumption in a unified TMIS device.
Ritamay Bhunia, Joo Sung Kim, Hayoung Oh, Dong Jun Kim, Seokyeong Lee, Cheolmin Park, Do Hwan Kim   +6 more
wiley   +1 more source

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Mild Cognitive Impairment

American Journal of Geriatric Psychiatry, 2005
AbstractWithin the cognitive functioning continuum from normal ageing to dementia three broad states can be distinguished: normal functioning for age, clear-cut impairment meeting diagnostic criteria for dementia, and mild cognitive impairment (MCI), which falls below normal but short of dementia in severity (Fig. 8.5.1.1.1).
Claudia Jacova, Howard Feldman
  +11 more sources