Results 51 to 60 of about 50,359 (288)

Task-evoked pulse wave amplitude tracks cognitive load

Scientific Reports, 2023
Cognitive load is a crucial factor in mentally demanding activities and holds significance across various research fields. This study aimed to investigate the effectiveness of pulse wave amplitude (PWA) as a measure for tracking cognitive load and ...
Yuri G. Pavlov, Anastasia S. Gashkova, Dauren Kasanov, Alexandra I. Kosachenko, Alexander I. Kotyusov, Boris Kotchoubey   +5 more
doaj   +1 more source

PLXDC2 siRNA‐Mediated Intervention Attenuates Microglial Senescence Through cGAS‐STING Signaling

Advanced Science, EarlyView.
PLXDC2 was identified as a microglial target in Parkinson's disease through human and mouse single‐cell analyses. Ferritin‐armed biomimetic nanovesicles delivered PLXDC2 siRNA, deferoxamine, and CeO2 nanoparticles across the blood–brain barrier, reducing cGAS‐STING activation, iron burden, oxidative stress, and senescence in microglia, thereby ...
Heyue Lu, Zitian Zheng, Feiran Wang, Huanhuan Luo, Fei Ju, Yucheng Zhu, Zheng Zhou, Jie Sun, Zhenghui Qiu, Xiang Luo, Zhongzheng Jia, Jianquan Wang, Hongjie Huang, Bo Zhang   +13 more
wiley   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

Predicting Users' Level of Disorientation for Their Level of Mental Model Completeness, Cognitive Over Load, Experience, and Gender [PDF]

Iranian Journal of Information Processing & Management
The objective of this study was to identify the roles of mental model, cognitive overload, experience, and gender, on the level of users' disorientation in interaction with the Google search engine.
yalda beizavi, mahdieh mirzabeigi, tahereh jowkar, alireza nikseresht   +3 more
doaj   +1 more source

An association between fibroblast growth factor 21 and cognitive impairment in iron-overload thalassemia

Scientific Reports, 2021
Although an increased fibroblast growth factor 21 (FGF21) level was related to mild cognitive impairment (MCI) in metabolic syndrome patients, any association regarding FGF21 and MCI in thalassemia patients as well as mechanistic insight are questionable.
Wasan Theerajangkhaphichai, Jirapas Sripetchwandee, Sirawit Sriwichaiin, Saovaros Svasti, Nipon Chattipakorn, Adisak Tantiworawit, Siriporn C. Chattipakorn   +6 more
doaj   +1 more source

Restores Aβ Clearance by Overcoming PCSK9–LRP1 Dysregulation and TRIB3‐Mediated Autophagy Blockade in Alzheimer's Disease

Advanced Science, EarlyView.
PCSK9 upregulation in cerebrovascular endothelial cells and microglia destabilizes the Aβ transporter LRP1, while TRIB3‐associated autophagy blockade further limits intracellular Aβ degradation. A RAP‐modified tea‐polyphenol nanoparticle co‐delivers siPCSK9 and siTRIB3 to restore LRP1‐mediated Aβ efflux and autophagy‐dependent degradation, reducing Aβ ...
Jie Miao, Jing Wang, Yankun Li, Haipei Zhang, Yanli Zhang, Qingnian Li, Bo Xiao, Wenhu Zhou, Junhong Guo   +8 more
wiley   +1 more source

From Local Interfaces to Global Challenges: Auditing Digital Noise on University Websites in Poland

Information
University website research to date tends to focus on conformity with technical standards. It rarely analyses the systemic nature of digital noise and its cognitive impacts.
Karol Król
doaj   +1 more source

Cognitive Overload Attack:Prompt Injection for Long Context

CoRR
40 pages, 31 ...
Bibek Upadhayay, Vahid Behzadan, Amin Karbasi   +2 more
openaire   +3 more sources

β‐Adducin Restrains PLA2G4A‐Dependent Lysosomal Membrane Permeabilization and Neuronal Death in Ischemic Stroke

Advanced Science, EarlyView.
This study identifies β‐adducin as a regulator of lysosomal integrity in ischemic neurons. Ischemia‐associated FTO loss increases m6A modification and destabilizes Add2 mRNA, reducing β‐adducin expression and promoting PLA2G4A accumulation at lysosomes.
Hui‐qin Li, Pin‐yi Liu, Dan Wu, Fei‐yu Ma, Yi Bai, Sheng‐nan Xia, Hai‐yan Yang, Xin‐yu Bao, Yun Xu, Xiang Cao   +9 more
wiley   +1 more source

Virtual reality and perceived learning effectiveness in accounting studies: the mediating role of task-technology fit

Cogent Business & Management
The use of virtual reality (VR) for the improvement of learning outcomes for accounting studies is an area in which the research is still limited. Technology-based accounting learning is very important because, currently, the accounting profession is ...
Dwi Ratmono, Ratna Candra Sari, Sony Warsono, Muhammad Ubaidillah, Luqman Mulki Wibowo   +4 more
doaj   +1 more source