Results 111 to 120 of about 3,140,461 (291)

The cognitive profile of ALS

Journal of neurology, neurosurgery, and psychiatry, 2016
Cognitive impairment is present in approximately 30% of patients with amyotrophic lateral sclerosis (ALS) and, especially when severe, has a negative impact on survival and caregiver burden. Our 2010 meta-analysis of the cognitive profile of ALS showed impairment of fluency, executive function, language and memory.
Beeldman, Emma, Raaphorst, Joost, Klein Twennaar, Michelle, de Visser, Marianne, Schmand, Ben A., de Haan, Rob J.   +5 more
openaire   +1 more source

Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova, Jan Smeitink, Herma Renkema, Rosabeth White, Frankie Barton, Rachel Lyon, Jane Newman, Aye Moe, Yi Shiau Ng, Grainne Siobhan Gorman   +9 more
wiley   +1 more source

Using video game telemetry data to research motor chunking, action latencies, and complex cognitive-motor skill learning

, 2017
Many theories of complex cognitive‐motor skill learning are built on the notion that basic cognitive processes group actions into easy‐to‐perform sequences. The present work examines predictions derived from laboratory‐based studies of motor chunking and

core   +1 more source

A person-centered approach to cognitive performance analysis in primary school children: Comparisons through self-organizing maps.

PLoS ONE
The objective of this study was to identify distinct student profiles based on physical, psychological, and social characteristics, and examine their impact on cognitive performance.
Sergio Montalt-García, Isaac Estevan, Israel Villarrasa-Sapiña, Xavier García-Massó   +3 more
doaj   +1 more source

Characterizing Cutaneous α‐Synuclein Deposition and Seeding Activity in Parkinson's Disease Subtypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cutaneous phosphorylated α‐synuclein (p‐syn) and α‐synuclein seeding activity are promising biomarkers for Parkinson's disease (PD), but their clinical value remains uncertain due to disease heterogeneity. This study evaluates these two biomarkers in PD patients to inform phenotype‐specific diagnosis and disease severity assessment ...
Yuting Jin, Tianyuan Yang, Minglei Liu, Haiyang Luo, Jing Yuan, Ke Zhang, Xinsheng Han, Jing Yang, Yuming Xu   +8 more
wiley   +1 more source

Neurologic Manifestations of Long COVID Affect Adult Females More Severely Than Males

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize differences in neurologic manifestations of postacute sequelae of SARS‐CoV‐2 infection (Neuro‐PASC) between females and males. Methods Cross‐sectional study of the first consecutive 261 posthospitalization Neuro‐PASC (PNP) and 2068 nonhospitalized Neuro‐PASC (NNP) patients evaluated at the Neuro‐COVID clinic between ...
Hannah Kopinsky, Melissa Lopez, Janet Miller, Millenia Jimenez, Eric M. Liotta, Igor J. Koralnik   +5 more
wiley   +1 more source

SCRIPTKELL : a tool for measuring cognitive effort and time processing in writing and other complex cognitive activities [PDF]

, 1999
We present SCRIPTKELL, a computer-assisted experimental tool that makes it possible to measure the time and cognitive effort allocated to the subprocesses of writing and other cognitive activities, SCRIPTKELL was designed to easily use and modulate ...
Roussey, JY, Olive, O, Piolat, A, Ziegler, J C, Thunin, O   +4 more
core  

Quantitative MRI Uncovers Subtle Cortical Damage in Myelin Oligodendrocyte Glycoprotein Antibody‐Associated Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether myelin‐sensitive quantitative MRI reveals microstructural abnormalities in normal‐appearing cortex (NACtx) in myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), indicating that conventional MRI underestimates remission residual cortical injury.
Valentina Camera, Agnese Tamanti, Silvia Messina, Nicola Dall'Osto, Teresa Maltempo, Stefano Ziccardi, Matteo Foschi, Maria Grazia Piscaglia, Diana Ferraro, Francesco Crescenzo, Francesca Rossi, Albulena Bajrami, Sabrina Marangoni, Damiano Marastoni, Francesca Benedetta Pizzini, Maria Isabel Leite, Roberta Magliozzi, Patrick Waters, Massimiliano Calabrese, Jacqueline Palace, Ruth Geraldes   +20 more
wiley   +1 more source

Profiles of Cognitive Functioning in Subjects with Neurological Disorders

, 1997
This report completes a four-year funded project designed to develop a data bank of Neurobehavioral Cognitive Status Examinations (NCSE) profiles of patients with neurological based disorders. Seven facilities participated in the study. Twenty categories
Margarethe Cammermeyer, Prendergast, V, Cammermeyer, M, Virginia Prendergast   +3 more
core   +1 more source

Natural Frequencies of Levodopa‐Induced Dyskinesia in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Abnormal involuntary movements, known as dyskinesias, are common complications of levodopa treatment in patients with Parkinson's disease and can significantly impair quality of life. The underlying pathophysiology remains unclear, and current therapeutic options are limited.
Ioannis U. Isaias, Federica Avantaggiato, Gianni Pezzoli, Andrea Canessa   +3 more
wiley   +1 more source